HitPredict

Interactor 1: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Interactor 2: SH3G2 (Q99962)
Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
Gene: SH3GL2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	21900206
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH3_2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 533 Hs			1 352
+	Mm
		1143916 BLNK_MOUSE (78-520): 1.72e-37: 145: 23.27		SH3G1_MOUSE (1-352): 4.74e-84: 261: 69.02
+	Hs
		203249 SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Mm
		88459 D3Z656_MOUSE (10-439): 8.51e-22: 102: 13.33		SH3G2_MOUSE (1-352): 3.65e-95: 288: 98.86
+	Rn
		192354 SYNJ1_RAT (10-456): 4.75e-21: 99.7: 14.26		SH3G2_RAT (1-352): 2.12e-95: 289: 98.58
+	Mm
		88460 D3Z656_MOUSE (10-439): 8.51e-22: 102: 13.33		SH3G3_MOUSE (1-351): 3.62e-90: 276: 64.67
+	Rn
		192356 SYNJ1_RAT (10-456): 4.75e-21: 99.7: 14.26		SH3G3_RAT (1-352): 2.37e-87: 268: 65.06
+	Hs
		203248 SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Rn
		193638 SYNJ1_RAT (10-456): 4.75e-21: 99.7: 14.26		SH3G1_RAT (1-352): 4.69e-84: 261: 69.57
+	Hs
		1024136 LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00		SH3R1_HUMAN (287-346): 1.48e-12: 70.9: 42.19
+	Hs
		924534 LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Mm
		1141127 LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98		GRB2_MOUSE (295-351): 1.71e-12: 67.8: 43.10
+	Hs
		924670 CLNK_HUMAN (182-528): 1.05e-42: 159: 25.00		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Mm
		1246941 BLNK_MOUSE (78-520): 1.72e-37: 145: 23.27		SH3K1_MOUSE (280-347): 3.72e-10: 63.2: 44.00
+	Hs
		924727 BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Mm
		222321 O54737_MOUSE (52-523): 4.71e-33: 134: 19.88		GRB2_MOUSE (295-351): 1.71e-12: 67.8: 43.10
+	Hs
		924632 TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		203218 SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		203192 SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71		SRBS2_HUMAN (296-347): 7.69e-10: 62.4: 51.92
+	Hs
		203230 SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71		SH319_HUMAN (296-347): 6.75e-10: 62.4: 55.77
+	Rn
		192744 SYNJ1_RAT (10-456): 4.75e-21: 99.7: 14.26		SRBS2_RAT (295-352): 1.15e-10: 65.1: 34.72