HitPredict

Interactor 1: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Interactor 2: BAP1 (Q92560)
Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6)
Gene: BAP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.706

Property	Details
Experiments	29686263, 32509391, 34591877, 35446349, 19615732
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 183 Hs			1 729
+	Hs
		800477 CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89		BAP1_HUMAN (1-729): 0: 1185: 100.00
+	Hs
		949856 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		BAP1_HUMAN (1-729): 0: 1185: 100.00
+	Hs
		327870 CBX7_HUMAN (21-181): 5.6e-29: 109: 22.78		UCHL5_HUMAN (5-324): 7.45e-131: 392: 35.71
+	Hs
		456544 CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33		UCHL1_HUMAN (7-236): 1.69e-68: 226: 22.27