HitPredict

Interactor 1: REEP3 (Q6NUK4)
Receptor expression-enhancing protein 3
Gene: REEP3

Interactor 2: REEP1 (Q9H902)
Receptor expression-enhancing protein 1 (Spastic paraplegia 31 protein)
Gene: REEP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005881 - cytoplasmic microtubule GO:0008017 - microtubule binding GO:0071782 - endoplasmic reticulum tubular network GO:0071786 - endoplasmic reticulum tubular network organization
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 201
+	Hs
		1238312 REEP3_HUMAN (1-255): 5.35e-107: 311: 100.00		REEP2_HUMAN (1-200): 5.31e-80: 240: 66.18
+	Hs
		1238316 REEP3_HUMAN (1-255): 5.35e-107: 311: 100.00		REEP4_HUMAN (1-182): 2.58e-76: 231: 66.48
+	Hs
		1411239 REEP4_HUMAN (1-250): 3.39e-91: 271: 53.70		REEP2_HUMAN (1-200): 5.31e-80: 240: 66.18
+	Hs
		1434944 REEP4_HUMAN (1-250): 3.39e-91: 271: 53.70		REEP1_HUMAN (1-201): 1e-79: 238: 100.00
+	Hs
		1411241 REEP2_HUMAN (1-250): 4.6e-86: 258: 50.39		REEP1_HUMAN (1-201): 1e-79: 238: 100.00
+	Hs
		1027182 REEP4_HUMAN (1-250): 3.39e-91: 271: 53.70		REEP5_HUMAN (1-133): 2.78e-61: 190: 32.09
+	Hs
		1027156 REEP2_HUMAN (1-250): 4.6e-86: 258: 50.39		REEP5_HUMAN (1-133): 2.78e-61: 190: 32.09
+	Hs
		1027185 REEP1_HUMAN (1-162): 1.58e-72: 222: 73.46		REEP5_HUMAN (1-133): 2.78e-61: 190: 32.09
+	At
		1299593 HA22J_ARATH (1-251): 1.03e-57: 186: 24.81		HA22J_ARATH (1-192): 9.96e-68: 209: 28.64
+	Mm
		1423685 Q9CQG4_MOUSE (1-125): 2.35e-58: 185: 28.57		Q9CQG4_MOUSE (1-133): 9.37e-61: 189: 31.34
+	Hs
		1027134 REEP5_HUMAN (1-125): 8.98e-59: 186: 28.57		REEP6_HUMAN (1-146): 1.34e-59: 187: 30.67