HitPredict

Interactor 1: ERCC8 (Q13216)
DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA)
Gene: ERCC8

Interactor 2: CSN5 (Q92905)
COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1)
Gene: COPS5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.712

Property	Details
Experiments	29531219, 34581821, 12732143, 19615732, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 396 Hs			1 334
+	Hs
		903414 WDR5_HUMAN (218-396): 2.25e-46: 163: 20.44		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		1017416 CDC20_HUMAN (69-352): 8.11e-11: 65.5: 23.81		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		197067 PRP4_HUMAN (89-272): 1.17e-10: 65.1: 26.27		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		124920 FBXW7_HUMAN (128-395): 4.9e-60: 208: 13.76		EIF3F_HUMAN (44-328): 3.25e-64: 208: 14.48
+	Hs
		130829 WDR5_HUMAN (218-396): 2.25e-46: 163: 20.44		PSDE_HUMAN (50-331): 1.67e-79: 246: 31.51
+	Hs
		124819 WDR5_HUMAN (218-396): 2.25e-46: 163: 20.44		EIF3F_HUMAN (44-328): 3.25e-64: 208: 14.48
+	Hs
		1138819 SNR40_HUMAN (140-394): 5.23e-55: 186: 13.41		MYSM1_HUMAN (39-172): 3.5e-29: 119: 23.29