Protein: SCN2B
Sodium channel regulatory subunit beta-2

Gene: SCN2B
Organism: Homo sapiens
Interactions: 189
UniProt ID: O60939

Gene Ontology (top 5):
GO:0001518 - voltage-gated sodium channel complex
GO:0005886 - plasma membrane
GO:0007268 - chemical synaptic transmission
GO:0007399 - nervous system development
GO:0009408 - response to heat

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

248812

GSDME
Gasdermin-E

4

1

High-throughput

0.892

High

262202

PTPRF
Receptor-type tyrosine-protein phosphatase F

4

8

High-throughput

0.892

High

262208

PTPRD
Receptor-type tyrosine-protein phosphatase delta

4

8

High-throughput

0.892

High

262211

MTOR
Serine/threonine-protein kinase mTOR

4

15

High-throughput

0.892

High

262199

CO4A
Complement C4-A

3

4

High-throughput

0.861

High

262288

EXOC2
Exocyst complex component 2

3

4

High-throughput

0.839

High

262342

PLAP
Phospholipase A-2-activating protein

3

1

High-throughput

0.839

High

262227

ATR
Serine/threonine-protein kinase ATR

4

14

High-throughput

0.797

High

262305

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

4

9

High-throughput

0.797

High

262205

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.698

High

262186

HIP1R
Huntingtin-interacting protein 1-related protein

4

1

High-throughput

0.691

High

262191

UTP20
Small subunit processome component 20 homolog

4

3

High-throughput

0.691

High

262214

KNTC1
Kinetochore-associated protein 1

4

1

High-throughput

0.691

High

262237

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

4

4

High-throughput

0.691

High

262264

S39AB
Zinc transporter ZIP11

4

9

High-throughput

0.691

High

262272

CIP2A
Protein CIP2A

4

5

High-throughput

0.691

High

262290

XPO6
Exportin-6

4

3

High-throughput

0.691

High

262340

EXOC7
Exocyst complex component 7

4

1

High-throughput

0.691

High

262213

DYN2
Dynamin-2

3

3

High-throughput

0.667

High

262219

DYN1
Dynamin-1

3

3

High-throughput

0.667

High

262286

COG3
Conserved oligomeric Golgi complex subunit 3

3

2

High-throughput

0.667

High

262319

DIAP3
Protein diaphanous homolog 3

3

4

High-throughput

0.667

High

262341

DYN3
Dynamin-3

3

4

High-throughput

0.667

High

262337

VPS28
Vacuolar protein sorting-associated protein 28 homolog

4

0

High-throughput

0.661

High

262262

EXOC8
Exocyst complex component 8

3

1

High-throughput

0.650

High

137158

EXOC5
Exocyst complex component 5

4

1

High-throughput

0.630

High

208005

TTI1
TELO2-interacting protein 1 homolog

4

2

High-throughput

0.630

High

230858

ORC5
Origin recognition complex subunit 5

4

3

High-throughput

0.630

High

245386

OPA1
Dynamin-like GTPase OPA1, mitochondrial

4

4

High-throughput

0.630

High

255717

USO1
General vesicular transport factor p115

4

1

High-throughput

0.630

High

262233

COG2
Conserved oligomeric Golgi complex subunit 2

4

2

High-throughput

0.630

High

262235

UBE3C
Ubiquitin-protein ligase E3C

4

2

High-throughput

0.630

High

262240

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

4

4

High-throughput

0.630

High

262251

THADA
tRNA

4

2

High-throughput

0.630

High

262299

XPO4
Exportin-4

4

16

High-throughput

0.630

High

262300

INT2
Integrator complex subunit 2

4

1

High-throughput

0.630

High

262318

F1142
Protein FAM114A2

4

1

High-throughput

0.630

High

262320

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

4

5

High-throughput

0.630

High

262330

GPN3
GPN-loop GTPase 3

4

2

High-throughput

0.630

High

262332

IPO11
Importin-11

4

13

High-throughput

0.630

High

262334

XPO7
Exportin-7

4

19

High-throughput

0.630

High

262346

TNPO3
Transportin-3

4

19

High-throughput

0.630

High

262295

LST8
Target of rapamycin complex subunit LST8

1

3

High-throughput

0.618

High

262218

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

3

High-throughput

0.618

High

262267

AT11C
Phospholipid-transporting ATPase IG

1

3

High-throughput

0.618

High

262329

DDX20
Probable ATP-dependent RNA helicase DDX20

2

0

High-throughput

0.617

High

262209

COT2
COUP transcription factor 2

2

2

High-throughput

0.611

High

262271

EXOC6
Exocyst complex component 6

2

3

High-throughput

0.611

High

261680

HUS1
Checkpoint protein HUS1

3

1

High-throughput

0.609

High

262187

CAND2
Cullin-associated NEDD8-dissociated protein 2

3

18

High-throughput

0.609

High

262215

RRP1
Ribosomal RNA processing protein 1 homolog A

3

3

High-throughput

0.609

High

262226

TBB3
Tubulin beta-3 chain

3

4

High-throughput

0.609

High

262254

HEAT3
HEAT repeat-containing protein 3

3

1

High-throughput

0.609

High

262275

COG1
Conserved oligomeric Golgi complex subunit 1

3

1

High-throughput

0.609

High

262279

CDS1
Phosphatidate cytidylyltransferase 1

3

4

High-throughput

0.609

High

262294

TBCD
Tubulin-specific chaperone D

3

2

High-throughput

0.609

High

262243

RIF1
Telomere-associated protein RIF1

2

2

High-throughput

0.601

High

164493

TNPO2
Transportin-2

3

14

High-throughput

0.599

High

262284

SAAL1
Protein SAAL1

3

5

High-throughput

0.593

High

262312

COG4
Conserved oligomeric Golgi complex subunit 4

3

2

High-throughput

0.593

High

262343

EXC6B
Exocyst complex component 6B

3

3

High-throughput

0.593

High

262344

COG6
Conserved oligomeric Golgi complex subunit 6

3

2

High-throughput

0.593

High

262291

TS101
Tumor susceptibility gene 101 protein

2

0

High-throughput

0.576

High

160955

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

1

High-throughput

0.575

High

262190

GPC4
Glypican-4

1

1

High-throughput

0.575

High

262200

ELFN1
Protein ELFN1

1

4

High-throughput

0.575

High

262201

CALM1
Calmodulin-1

1

1

High-throughput

0.575

High

262206

LEG3
Galectin-3

1

13

High-throughput

0.575

High

262224

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

8

High-throughput

0.575

High

262316

NECT3
Nectin-3

1

18

High-throughput

0.575

High

262345

PLXD1
Plexin-D1

1

5

High-throughput

0.575

High

262225

TARB1
tRNA

2

2

High-throughput

0.558

High

262273

IPO4
Importin-4

2

13

High-throughput

0.558

High

262283

GCP3
Gamma-tubulin complex component 3

2

1

High-throughput

0.558

High

262348

5MP1
eIF5-mimic protein 1

2

1

High-throughput

0.558

High

262223

ATM
Serine-protein kinase ATM

1

14

High-throughput

0.553

High

262248

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

1

5

High-throughput

0.553

High

262322

EXOC1
Exocyst complex component 1

2

0

High-throughput

0.547

High

262231

LRC32
Transforming growth factor beta activator LRRC32

1

0

High-throughput

0.546

High

211694

ZW10
Centromere/kinetochore protein zw10 homolog

2

1

High-throughput

0.521

High

262221

NU160
Nuclear pore complex protein Nup160

2

1

High-throughput

0.521

High

262241

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

2

1

High-throughput

0.521

High

262278

GCN1
Stalled ribosome sensor GCN1

2

12

High-throughput

0.521

High

262307

HEAT1
HEAT repeat-containing protein 1

2

2

High-throughput

0.521

High

262321

MDN1
Midasin

2

3

High-throughput

0.521

High

127229

LEG8
Galectin-8

1

13

High-throughput

0.514

High

262217

HBA
Hemoglobin subunit alpha

1

1

High-throughput

0.514

High

262252

UN13D
Protein unc-13 homolog D

1

4

High-throughput

0.514

High

262289

SMG1
Serine/threonine-protein kinase SMG1

1

13

High-throughput

0.514

High

262296

NUP85
Nuclear pore complex protein Nup85

1

1

High-throughput

0.514

High

262314

NEK6
Serine/threonine-protein kinase Nek6

1

2

High-throughput

0.514

High

262323

ARP10
Actin-related protein 10

1

3

High-throughput

0.514

High

262324

SACS
Sacsin

1

1

High-throughput

0.514

High

262349

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

1

High-throughput

0.514

High

173634

BTAF1
TATA-binding protein-associated factor 172

1

0

High-throughput

0.481

High

262266

ASCC3
Activating signal cointegrator 1 complex subunit 3

1

0

High-throughput

0.481

High

262270

NUP37
Nucleoporin Nup37

1

0

High-throughput

0.481

High

262317

EI2BG
Translation initiation factor eIF2B subunit gamma

1

2

High-throughput

0.479

High

262331

EI2BD
Translation initiation factor eIF2B subunit delta

1

3

High-throughput

0.479

High

251177

RNBP6
Ran-binding protein 6

1

12

High-throughput

0.445

High

262185

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

3

High-throughput

0.445

High

262207

NF1
Neurofibromin

1

4

High-throughput

0.445

High

262229

RIN1
Ras and Rab interactor 1

1

1

High-throughput

0.445

High

262230

DOCK1
Dedicator of cytokinesis protein 1

1

9

High-throughput

0.445

High

262232

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

6

High-throughput

0.445

High

262261

NXP20
Protein NOXP20

1

1

High-throughput

0.445

High

262269

CCNY
Cyclin-Y

1

2

High-throughput

0.445

High

262297

AP1M1
AP-1 complex subunit mu-1

1

1

High-throughput

0.445

High

262309

DOCK5
Dedicator of cytokinesis protein 5

1

4

High-throughput

0.445

High

262325

ATX10
Ataxin-10

1

1

High-throughput

0.445

High

262282

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

1

2

High-throughput

0.437

High

262265

GPD1L
Glycerol-3-phosphate dehydrogenase 1-like protein

1

0

High-throughput

0.426

High

262281

EXOC4
Exocyst complex component 4

1

0

High-throughput

0.426

High

64750

RIMC1
RAB7A-interacting MON1-CCZ1 complex subunit 1

1

1

High-throughput

0.407

High

133899

IPO5
Importin-5

1

12

High-throughput

0.407

High

135420

DNM1L
Dynamin-1-like protein

1

3

High-throughput

0.407

High

172319

XPO1
Exportin-1

1

20

High-throughput

0.407

High

231424

ORC4
Origin recognition complex subunit 4

1

4

High-throughput

0.407

High

245039

AQR
RNA helicase aquarius

1

1

High-throughput

0.407

High

252798

EXOC3
Exocyst complex component 3

1

1

High-throughput

0.407

High

262188

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

1

High-throughput

0.407

High

262194

FRYL
Protein furry homolog-like

1

1

High-throughput

0.407

High

262195

CCNB2
G2/mitotic-specific cyclin-B2

1

1

High-throughput

0.407

High

262198

TBB5
Tubulin beta chain

1

4

High-throughput

0.407

High

262216

GEMI4
Gem-associated protein 4

1

1

High-throughput

0.407

High

262220

VAC14
Protein VAC14 homolog

1

18

High-throughput

0.407

High

262234

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

4

High-throughput

0.407

High

262236

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

6

High-throughput

0.407

High

262238

Q4LE60
TNPO2 variant protein

1

14

High-throughput

0.407

High

262239

RHG29
Rho GTPase-activating protein 29

1

2

High-throughput

0.407

High

262246

ZFY26
Zinc finger FYVE domain-containing protein 26

1

5

High-throughput

0.407

High

262247

HEAT6
HEAT repeat-containing protein 6

1

1

High-throughput

0.407

High

262249

RINT1
RAD50-interacting protein 1

1

1

High-throughput

0.407

High

262253

MON2
Protein MON2 homolog

1

5

High-throughput

0.407

High

262256

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

20

High-throughput

0.407

High

262260

DAAF5
Dynein axonemal assembly factor 5

1

2

High-throughput

0.407

High

262268

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

1

High-throughput

0.407

High

262276

TB22A
TBC1 domain family member 22A

1

2

High-throughput

0.407

High

262277

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

6

High-throughput

0.407

High

262280

FAKD4
FAST kinase domain-containing protein 4

1

4

High-throughput

0.407

High

262285

INT4
Integrator complex subunit 4

1

1

High-throughput

0.407

High

262287

ELMO2
Engulfment and cell motility protein 2

1

2

High-throughput

0.407

High

262292

CND3
Condensin complex subunit 3

1

1

High-throughput

0.407

High

262298

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.407

High

262301

CYRIA
CYFIP-related Rac1 interactor A

1

1

High-throughput

0.407

High

262303

F234A
Protein FAM234A

1

1

High-throughput

0.407

High

262306

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

1

High-throughput

0.407

High

262308

SMYD3
Histone-lysine N-methyltransferase SMYD3

1

1

High-throughput

0.407

High

262311

ZWILC
Protein zwilch homolog

1

1

High-throughput

0.407

High

262313

XPO5
Exportin-5

1

17

High-throughput

0.407

High

262315

GPN1
GPN-loop GTPase 1

1

2

High-throughput

0.407

High

262326

NCDN
Neurochondrin

1

1

High-throughput

0.407

High

262335

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

9

High-throughput

0.407

High

262339

COG5
Conserved oligomeric Golgi complex subunit 5

1

2

High-throughput

0.407

High

262347

SNX5
Sorting nexin-5

1

2

High-throughput

0.407

High

262245

RN213
E3 ubiquitin-protein ligase RNF213

4

0

High-throughput

0.360

High

262258

COMD2
COMM domain-containing protein 2

4

0

High-throughput

0.360

High

262263

RBFA
Putative ribosome-binding factor A, mitochondrial

4

0

High-throughput

0.360

High

262293

F118B
Protein FAM118B

4

0

High-throughput

0.360

High

262228

ITPK1
Inositol-tetrakisphosphate 1-kinase

3

0

High-throughput

0.347

High

262244

FOCAD
Focadhesin

3

0

High-throughput

0.347

High

262257

RETR3
Reticulophagy regulator 3

3

0

High-throughput

0.339

High

262255

NOP9
Nucleolar protein 9

2

0

High-throughput

0.298

High

262304

ATG10
Ubiquitin-like-conjugating enzyme ATG10

1

0

High-throughput

0.279

Low

63915

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.249

Low

177493

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.249

Low

91593

UMAD1
UBAP1-MVB12-associated

1

0

High-throughput

0.232

Low

214152

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

1

0

High-throughput

0.232

Low

262189

MED24
Mediator of RNA polymerase II transcription subunit 24

1

0

High-throughput

0.232

Low

262192

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

1

0

High-throughput

0.232

Low

262193

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.232

Low

262196

OAT
Ornithine aminotransferase, mitochondrial

1

0

High-throughput

0.232

Low

262197

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.232

Low

262203

UMPS
Uridine 5'-monophosphate synthase

1

0

High-throughput

0.232

Low

262204

PYGB
Glycogen phosphorylase, brain form

1

0

High-throughput

0.232

Low

262210

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.232

Low

262212

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.232

Low

262222

IFRD2
Interferon-related developmental regulator 2

1

0

High-throughput

0.232

Low

262242

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.232

Low

262250

PGM2L
Glucose 1,6-bisphosphate synthase

1

0

High-throughput

0.232

Low

262259

CNDG2
Condensin-2 complex subunit G2

1

0

High-throughput

0.232

Low

262274

PP4R1
Serine/threonine-protein phosphatase 4 regulatory subunit 1

1

0

High-throughput

0.232

Low

262302

SMG9
Nonsense-mediated mRNA decay factor SMG9

1

0

High-throughput

0.232

Low

262310

NOL11
Nucleolar protein 11

1

0

High-throughput

0.232

Low

262327

TFP11
Tuftelin-interacting protein 11

1

0

High-throughput

0.232

Low

262328

COPG2
Coatomer subunit gamma-2

1

0

High-throughput

0.232

Low

262333

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.232

Low

262336

DCTN4
Dynactin subunit 4

1

0

High-throughput

0.232

Low

262338

FBXL3
F-box/LRR-repeat protein 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025