HitPredict

Interactor 1: NMDE2 (Q13224)
Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3)
Gene: GRIN2B

Interactor 2: DLG3 (Q92796)
Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR)
Gene: DLG3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.713

Property	Details
Experiments	12738960, 11937501, 11997254, 9278515, 14529713
Identification Methods	affinity chromatography technology, pull down, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007268 - chemical synaptic transmission GO:0043005 - neuron projection GO:0098839 - postsynaptic density membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1484 Hs			1 817
+	Rn
		962664 NMDE2_RAT (1-1484): 0: 1829: 98.45		DLG3_RAT (1-817): 0: 689: 95.17
+	Mm
		936175 NMDE2_MOUSE (1-1484): 0: 1826: 98.45		DLG3_MOUSE (1-817): 0: 689: 95.05
+	Hs
		1021485 NMDE2_HUMAN (1-1484): 0: 1846: 100.00		DLG1_HUMAN (13-817): 0: 586: 63.90
+	Mm
		963751 NMDE2_MOUSE (1-1484): 0: 1826: 98.45		DLG1_MOUSE (3-817): 0: 592: 62.63
+	Rn
		962663 NMDE2_RAT (1-1484): 0: 1829: 98.45		DLG1_RAT (3-817): 0: 578: 61.42
+	Hs
		1018905 NMDE1_HUMAN (9-1484): 0: 1495: 52.39		DLG3_HUMAN (1-817): 0: 713: 100.00
+	Rn
		962656 NMDE1_RAT (9-1484): 0: 1506: 52.59		DLG3_RAT (1-817): 0: 689: 95.17
+	Rn
		962655 NMDE1_RAT (9-1484): 0: 1506: 52.59		DLG1_RAT (3-817): 0: 578: 61.42
+	Hs
		1018888 NMDE1_HUMAN (9-1484): 0: 1495: 52.39		DLG1_HUMAN (13-817): 0: 586: 63.90
+	Hs
		942337 NMDE2_HUMAN (1-1484): 0: 1846: 100.00		DLG4_HUMAN (50-285): 9.84e-26: 115: 20.25
+	Rn
		677781 NMDE2_RAT (1-1484): 0: 1829: 98.45		DLG4_RAT (50-282): 1.36e-25: 115: 20.50
+	Mm
		963732 NMDE2_MOUSE (1-1484): 0: 1826: 98.45		DLG4_MOUSE (50-285): 1.06e-25: 115: 20.25
+	Hs
		1028140 NMDE2_HUMAN (1-1484): 0: 1846: 100.00		DLG2_HUMAN (312-547): 2.24e-16: 86: 21.40
+	Rn
		962666 NMDE2_RAT (1-1484): 0: 1829: 98.45		DLG2_RAT (312-547): 1.37e-16: 86.4: 21.40
+	Mm
		963769 NMDE2_MOUSE (1-1484): 0: 1826: 98.45		DLG2_MOUSE (312-547): 1.48e-16: 86.4: 21.40
+	Mm
		723533 NMDE1_MOUSE (9-1484): 0: 1516: 52.79		DLG4_MOUSE (50-285): 1.06e-25: 115: 20.25
+	Rn
		677780 NMDE1_RAT (9-1484): 0: 1506: 52.59		DLG4_RAT (50-282): 1.36e-25: 115: 20.50
+	Hs
		942334 NMDE1_HUMAN (9-1484): 0: 1495: 52.39		DLG4_HUMAN (50-285): 9.84e-26: 115: 20.25
+	Rn
		962657 NMDE1_RAT (9-1484): 0: 1506: 52.59		DLG2_RAT (312-547): 1.37e-16: 86.4: 21.40
+	Hs
		1018896 NMDE1_HUMAN (9-1484): 0: 1495: 52.39		DLG2_HUMAN (312-547): 2.24e-16: 86: 21.40