Protein: RN216
E3 ubiquitin-protein ligase RNF216 (EC 2.3.2.27) (RING finger protein 216) (RING-type E3 ubiquitin transferase RNF216) (Triad domain-containing protein 3) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B)

Gene: RN216, RNF216
Organism: Homo sapiens
Interactions: 57
UniProt ID: Q9NWF9

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006915 - apoptotic process
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

996029

UB2L3
Ubiquitin-conjugating enzyme E2 L3

7

20

Small-scale

0.744

High

1451195

RN216
E3 ubiquitin-protein ligase RNF216

3

13

Small-scale

0.664

High

1109672

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

3

5

Small-scale

0.661

High

168572

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

3

20

Small-scale

0.653

High

1094993

TRAF3
TNF receptor-associated factor 3

2

12

Small-scale

0.634

High

294797

CAN15
Calpain-15

2

8

High-throughput

0.606

High

639318

TNAP3
Tumor necrosis factor alpha-induced protein 3

2

7

High-throughput

0.606

High

853535

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

2

6

High-throughput

0.606

High

943822

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

4

High-throughput

0.606

High

1353539

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

2

4

High-throughput

0.606

High

1386602

OPTN
Optineurin

2

7

High-throughput

0.606

High

1412792

UBAC1
Ubiquitin-associated domain-containing protein 1

2

1

High-throughput

0.606

High

508716

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

17

Small-scale

0.602

High

906797

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

20

Small-scale

0.602

High

957215

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.602

High

982338

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

20

Small-scale

0.602

High

1273194

ARC
Activity-regulated cytoskeleton-associated protein

2

1

Small-scale

0.584

High

1121653

MORC3
MORC family CW-type zinc finger protein 3

2

0

High-throughput

0.580

High

1218674

OTU1
Ubiquitin thioesterase OTU1

2

0

High-throughput

0.580

High

1329566

ZFN2A
AN1-type zinc finger protein 2A

2

0

High-throughput

0.580

High

1126770

BECN1
Beclin-1

2

0

Small-scale

0.559

High

126337

TLR4
Toll-like receptor 4

2

6

Small-scale

0.548

High

1116054

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.541

High

933930

RAD
GTP-binding protein RAD

1

1

High-throughput

0.536

High

977841

ACTA
Actin, aortic smooth muscle

1

6

High-throughput

0.536

High

1449857

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

3

Small-scale

0.523

High

1451197

RNF11
RING finger protein 11

1

4

High-throughput

0.508

High

1451196

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

Small-scale

0.501

High

946678

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

0

Small-scale

0.493

High

175513

KHNYN
Protein KHNYN

1

0

High-throughput

0.493

High

278169

FLNB
Filamin-B

1

1

Small-scale

0.481

High

799516

BRCA1
Breast cancer type 1 susceptibility protein

1

4

High-throughput

0.481

High

703724

MK01
Mitogen-activated protein kinase 1

1

0

Small-scale

0.480

High

964476

SUMO2
Small ubiquitin-related modifier 2

1

0

Small-scale

0.480

High

144196

UBE2C
Ubiquitin-conjugating enzyme E2 C

1

20

Small-scale

0.479

High

173446

XPO1
Exportin-1

1

6

High-throughput

0.479

High

550493

PABP1
Polyadenylate-binding protein 1

1

6

High-throughput

0.479

High

651723

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

2

Small-scale

0.479

High

714462

PML
Protein PML

1

8

High-throughput

0.479

High

971174

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

Small-scale

0.479

High

1005159

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1037409

H11
Histone H1.1

1

2

High-throughput

0.479

High

1037824

IRF8
Interferon regulatory factor 8

1

3

Small-scale

0.479

High

1048112

TLE3
Transducin-like enhancer protein 3

1

3

High-throughput

0.479

High

1307151

TCAM1
TIR domain-containing adapter molecule 1

1

1

Small-scale

0.479

High

1340822

COP1
E3 ubiquitin-protein ligase COP1

1

3

High-throughput

0.479

High

1448075

TLR9
Toll-like receptor 9

1

5

Small-scale

0.464

High

1193132

PKHN1
Pleckstrin homology domain-containing family N member 1

1

0

Small-scale

0.458

High

1350282

URGCP
Up-regulator of cell proliferation

1

1

High-throughput

0.445

High

191241

TLR3
Toll-like receptor 3

1

6

Small-scale

0.439

High

252290

TLR5
Toll-like receptor 5

1

5

Small-scale

0.439

High

1448088

TLR8
Toll-like receptor 8

1

5

Small-scale

0.437

High

1155194

EREP1
Endosomal transmembrane epsin interactor 1

1

2

Small-scale

0.417

High

1364832

F168A
Protein FAM168A

2

0

High-throughput

0.316

High

1406552

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

0

Small-scale

0.299

High

1325122

MTURN
Maturin

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025