Protein: IRF8
Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (H-ICSBP) (ICSBP)

Gene: IRF8
Organism: Homo sapiens
Interactions: 107
UniProt ID: Q02556

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

533921

IRF1
Interferon regulatory factor 1

5

16

Small-scale

0.920

High

571590

IRF2
Interferon regulatory factor 2

3

15

Small-scale

0.839

High

167188

IRF6
Interferon regulatory factor 6

1

15

High-throughput

0.757

High

609922

SPI1
Transcription factor PU.1

4

10

Small-scale

0.699

High

637885

NF1
Neurofibromin

4

2

Small-scale

0.683

High

838064

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

20

Small-scale

0.665

High

958623

CSN2
COP9 signalosome complex subunit 2

2

5

Small-scale

0.649

High

712724

IL12A
Interleukin-12 subunit alpha

3

7

Small-scale

0.640

High

623290

RO52
E3 ubiquitin-protein ligase TRIM21

2

9

Small-scale

0.634

High

1037781

IRF8
Interferon regulatory factor 8

1

15

Small-scale

0.618

High

1037796

IRF4
Interferon regulatory factor 4

1

15

Small-scale

0.618

High

1037806

CBP
CREB-binding protein

1

17

Small-scale

0.618

High

416959

CY24B
NADPH oxidase 2

4

3

Small-scale

0.617

High

378560

IL1B
Interleukin-1 beta

2

2

Small-scale

0.584

High

626457

NCF2
Neutrophil cytosol factor 2

2

3

Small-scale

0.584

High

749469

C2TA
MHC class II transactivator

2

7

Small-scale

0.584

High

711102

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

3

Small-scale

0.571

High

186539

TRI18
E3 ubiquitin-protein ligase Midline-1

1

15

High-throughput

0.536

High

549124

CDK4
Cyclin-dependent kinase 4

1

2

High-throughput

0.536

High

1037787

CSN1
COP9 signalosome complex subunit 1

1

3

High-throughput

0.536

High

1037801

CSN6
COP9 signalosome complex subunit 6

1

1

High-throughput

0.536

High

1037807

CSN5
COP9 signalosome complex subunit 5

1

2

High-throughput

0.536

High

1037814

CSN4
COP9 signalosome complex subunit 4

1

1

High-throughput

0.536

High

191209

TLR3
Toll-like receptor 3

1

13

Small-scale

0.515

High

425453

ISG15
Ubiquitin-like protein ISG15

1

10

Small-scale

0.515

High

963498

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

5

Small-scale

0.515

High

1037827

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.515

High

1037809

OPTN
Optineurin

1

6

High-throughput

0.515

High

1037822

FANCF
Fanconi anemia group F protein

1

0

Small-scale

0.512

High

1037788

ZBT17
Zinc finger and BTB domain-containing protein 17

1

1

Small-scale

0.508

High

626188

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

20

Small-scale

0.501

High

1037782

TF65
Transcription factor p65

1

20

Small-scale

0.501

High

482887

TPM1
Tropomyosin alpha-1 chain

1

1

High-throughput

0.500

High

995406

TPM4
Tropomyosin alpha-4 chain

1

1

High-throughput

0.500

High

1037802

MYH14
Myosin-14

1

2

High-throughput

0.500

High

1037826

MYO6
Unconventional myosin-VI

1

2

High-throughput

0.500

High

126305

TLR4
Toll-like receptor 4

1

14

Small-scale

0.479

High

138992

BCL9
B-cell CLL/lymphoma 9 protein

1

11

High-throughput

0.479

High

142679

TRI38
E3 ubiquitin-protein ligase TRIM38

1

10

Small-scale

0.479

High

161448

KMT2D
Histone-lysine N-methyltransferase 2D

1

7

High-throughput

0.479

High

174340

ZN609
Zinc finger protein 609

1

5

High-throughput

0.479

High

194548

KDM6A
Lysine-specific demethylase 6A

1

4

High-throughput

0.479

High

239567

MED14
Mediator of RNA polymerase II transcription subunit 14

1

9

Small-scale

0.479

High

324116

CE152
Centrosomal protein of 152 kDa

1

4

High-throughput

0.479

High

340871

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

20

Small-scale

0.479

High

378372

IFNB
Interferon beta

1

20

Small-scale

0.479

High

403991

GCR
Glucocorticoid receptor

1

5

Small-scale

0.479

High

407077

HG2A
HLA class II histocompatibility antigen gamma chain

1

1

Small-scale

0.479

High

484108

PGFRB
Platelet-derived growth factor receptor beta

1

2

Small-scale

0.479

High

519488

MYBB
Myb-related protein B

1

2

High-throughput

0.479

High

586273

ZEP1
Zinc finger protein 40

1

1

High-throughput

0.479

High

587055

ITF2
Transcription factor 4

1

1

Small-scale

0.479

High

606655

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

624245

TFE3
Transcription factor E3

1

1

High-throughput

0.479

High

651283

CBL
E3 ubiquitin-protein ligase CBL

1

13

Small-scale

0.479

High

659213

SP100
Nuclear autoantigen Sp-100

1

5

Small-scale

0.479

High

668559

APC
Adenomatous polyposis coli protein

1

5

Small-scale

0.479

High

681790

RBTN2
Rhombotin-2

1

1

Small-scale

0.479

High

702395

CYTD
Cystatin-D

1

3

Small-scale

0.479

High

725040

HXC8
Homeobox protein Hox-C8

1

6

Small-scale

0.479

High

822138

PSB10
Proteasome subunit beta type-10

1

9

Small-scale

0.479

High

832693

BCL6
B-cell lymphoma 6 protein

1

5

Small-scale

0.479

High

832972

ETV6
Transcription factor ETV6

1

10

Small-scale

0.479

High

878984

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

1030954

FLI1
Friend leukemia integration 1 transcription factor

1

3

High-throughput

0.479

High

1037783

TLE1
Transducin-like enhancer protein 1

1

3

High-throughput

0.479

High

1037784

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

3

Small-scale

0.479

High

1037785

NFIA
Nuclear factor 1 A-type

1

3

High-throughput

0.479

High

1037786

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

4

Small-scale

0.479

High

1037789

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

2

Small-scale

0.479

High

1037790

NR1H3
Oxysterols receptor LXR-alpha

1

1

Small-scale

0.479

High

1037791

SQSTM
Sequestosome-1

1

3

Small-scale

0.479

High

1037792

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1037797

MED1
Mediator of RNA polymerase II transcription subunit 1

1

10

Small-scale

0.479

High

1037799

ARI4B
AT-rich interactive domain-containing protein 4B

1

9

High-throughput

0.479

High

1037803

IFNL1
Interferon lambda-1

1

7

Small-scale

0.479

High

1037808

DHX58
ATP-dependent RNA helicase DHX58

1

11

Small-scale

0.479

High

1037810

ZBT10
Zinc finger and BTB domain-containing protein 10

1

9

High-throughput

0.479

High

1037811

Z512B
Zinc finger protein 512B

1

5

High-throughput

0.479

High

1037812

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

5

High-throughput

0.479

High

1037813

CIC
Protein capicua homolog

1

6

High-throughput

0.479

High

1037816

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

7

Small-scale

0.479

High

1037817

AICDA
Single-stranded DNA cytosine deaminase

1

2

Small-scale

0.479

High

1037820

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

4

High-throughput

0.479

High

1037824

RN216
E3 ubiquitin-protein ligase RNF216

1

3

Small-scale

0.479

High

1037825

PRR12
Proline-rich protein 12

1

7

High-throughput

0.479

High

1034919

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

0

Small-scale

0.458

High

1037795

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

0

Small-scale

0.458

High

1037798

VPS72
Vacuolar protein sorting-associated protein 72 homolog

1

0

High-throughput

0.458

High

1037815

PDC10
Programmed cell death protein 10

1

0

Small-scale

0.458

High

1037818

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

0

High-throughput

0.458

High

1037819

ZN644
Zinc finger protein 644

1

0

High-throughput

0.458

High

299158

FLOT1
Flotillin-1

1

6

High-throughput

0.457

High

1037793

FLOT2
Flotillin-2

1

6

High-throughput

0.457

High

342542

LY86
Lymphocyte antigen 86

1

1

Small-scale

0.437

High

1030415

DIAC
Di-N-acetylchitobiase

1

1

Small-scale

0.437

High

1037794

GPR18
N-arachidonyl glycine receptor

1

3

Small-scale

0.437

High

1037804

IFNL3
Interferon lambda-3

1

7

Small-scale

0.437

High

541959

TOP1
DNA topoisomerase 1

1

3

Small-scale

0.408

High

962931

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.269

Low

388118

ACHA
Acetylcholine receptor subunit alpha

1

0

Small-scale

0.249

Low

566639

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.249

Low

1037800

CST9
Cystatin-9

1

0

Small-scale

0.249

Low

1037805

BANK1
B-cell scaffold protein with ankyrin repeats

1

0

Small-scale

0.249

Low

1037821

CHSTB
Carbohydrate sulfotransferase 11

1

0

Small-scale

0.249

Low

1037823

CAH10
Carbonic anhydrase-related protein 10

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025