HitPredict

Interactor 1: SRSF6 (Q13247)
Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)
Gene: SRSF6

Interactor 2: SREK1 (Q8WXA9)
Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12) (Splicing regulatory protein 508) (SRrp508)
Gene: SREK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 14559993
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 344 Hs			1 508
+	Hs
		992862 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		SREK1_HUMAN (1-508): 1.81e-52: 187: 100.00
+	Hs
		1028585 SRSF9_HUMAN (3-222): 5.6e-49: 165: 34.22		SREK1_HUMAN (1-508): 1.81e-52: 187: 100.00
+	Hs
		993782 SRSF4_HUMAN (1-323): 1.85e-45: 163: 63.47		SREK1_HUMAN (1-508): 1.81e-52: 187: 100.00
+	Hs
		1028752 SRSF5_HUMAN (2-180): 3.02e-46: 160: 64.25		SREK1_HUMAN (1-508): 1.81e-52: 187: 100.00
+	Hs
		1031403 PABP4_HUMAN (101-191): 1.26e-12: 70.7: 21.88		SREK1_HUMAN (1-508): 1.81e-52: 187: 100.00
+	Hs
		516607 PABP1_HUMAN (101-191): 1.28e-11: 67.6: 19.79		SREK1_HUMAN (1-508): 1.81e-52: 187: 100.00
+	Hs
		952059 SRSF3_HUMAN (3-78): 2.4e-09: 57.4: 46.84		SREK1_HUMAN (1-508): 1.81e-52: 187: 100.00
+	At
		983454 PABP5_ARATH (3-193): 7.09e-27: 113: 16.34		CID8_ARATH (20-152): 8.54e-16: 80.2: 28.36
+	At
		790118 PABP2_ARATH (109-194): 1.77e-11: 67.2: 24.18		CID12_ARATH (20-147): 3.84e-22: 99.4: 29.69
+	At
		790115 PABP2_ARATH (109-194): 1.77e-11: 67.2: 24.18		CID8_ARATH (20-152): 8.54e-16: 80.2: 28.36