HitPredict

Interactor 1: SRSF6 (Q13247)
Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)
Gene: SRSF6

Interactor 2: RBM7 (Q9Y580)
RNA-binding protein 7 (RNA-binding motif protein 7)
Gene: RBM7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000381 - regulation of alternative mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 344 Hs			1 266
+	Hs
		1314649 RBM4_HUMAN (1-343): 1.17e-47: 166: 17.05		RBM7_HUMAN (1-266): 2.96e-58: 188: 100.00
+	Hs
		516478 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		PABP1_HUMAN (4-256): 1.02e-38: 144: 14.71
+	Hs
		516674 RBM4_HUMAN (1-343): 1.17e-47: 166: 17.05		PABP1_HUMAN (4-256): 1.02e-38: 144: 14.71
+	Hs
		516493 SRSF9_HUMAN (3-222): 5.6e-49: 165: 34.22		PABP1_HUMAN (4-256): 1.02e-38: 144: 14.71
+	Mm
		936481 SRSF1_MOUSE (3-188): 3.02e-54: 180: 36.65		TIAR_MOUSE (2-205): 5.73e-30: 117: 16.30
+	Hs
		474020 SRSF6_HUMAN (1-323): 3.2e-43: 154: 100.00		PAB4L_HUMAN (4-171): 1.42e-33: 126: 14.52
+	Hs
		474021 PAB4L_HUMAN (1-196): 1.97e-35: 134: 15.94		PABP4_HUMAN (4-262): 1.83e-39: 146: 15.14
+	Hs
		992743 SRSF1_HUMAN (3-188): 3.02e-54: 180: 36.65		ELAV2_HUMAN (2-205): 9.2e-23: 97.4: 16.09
+	Mm
		665745 TIA1_MOUSE (2-335): 1.54e-33: 129: 15.46		PABP1_MOUSE (4-256): 8.91e-39: 144: 15.07
+	Mm
		857324 Q542V3_MOUSE (1-343): 1.15e-52: 182: 51.93		TIA1_MOUSE (3-187): 3.59e-16: 79: 14.21
+	Mm
		857340 SRSF1_MOUSE (3-188): 3.02e-54: 180: 36.65		TIA1_MOUSE (3-187): 3.59e-16: 79: 14.21
+	Mm
		1207996 RBM4_MOUSE (1-343): 1.34e-43: 155: 18.18		CSTFT_MOUSE (3-157): 5.11e-22: 97.1: 22.56
+	Hs
		1020247 SRSF6_HUMAN (1-323): 3.2e-43: 154: 100.00		ELAV2_HUMAN (2-205): 9.2e-23: 97.4: 16.09
+	Hs
		1073633 RBM4_HUMAN (1-343): 1.17e-47: 166: 17.05		SF3B4_HUMAN (7-242): 3.59e-15: 76.6: 15.39
+	Sc
		376649 GBP2_YEAST (4-203): 4.8e-23: 100: 19.05		PABP_YEAST (10-258): 4.72e-37: 139: 15.22
+	Hs
		474019 PAB4L_HUMAN (1-196): 1.97e-35: 134: 15.94		ELAV2_HUMAN (2-205): 9.2e-23: 97.4: 16.09
+	Hs
		1028926 SRSF6_HUMAN (1-323): 3.2e-43: 154: 100.00		SF3B4_HUMAN (7-242): 3.59e-15: 76.6: 15.39
+	Sc
		376899 NOP3_YEAST (3-326): 1.19e-19: 91.2: 19.94		PABP_YEAST (10-258): 4.72e-37: 139: 15.22
+	Sc
		633929 GBP2_YEAST (4-203): 4.8e-23: 100: 19.05		PUB1_YEAST (6-108): 4.83e-15: 76.3: 30.10
+	Sc
		694191 NOP3_YEAST (3-326): 1.19e-19: 91.2: 19.94		PUB1_YEAST (6-108): 4.83e-15: 76.3: 30.10