HitPredict

Interactor 1: SRSF2 (Q01130)
Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)
Gene: SRSF2

Interactor 2: SRSF8 (Q9BRL6)
Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B)
Gene: SRSF8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31839598, 34349018
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000381 - regulation of alternative mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006397 - mRNA processing and 2 others more... GO:0008380 - RNA splicing GO:0016607 - nuclear speck
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 221 Hs			1 282
+	Hs
		1029452 SRSF2_HUMAN (1-221): 1.23e-43: 147: 100.00		SRSF2_HUMAN (1-100): 1.3e-41: 144: 80.00
+	Hs
		1090289 ELAV2_HUMAN (1-195): 3.76e-37: 134: 15.79		SRSF8_HUMAN (1-282): 5.36e-41: 144: 100.00
+	Hs
		1029573 SRSF2_HUMAN (1-221): 1.23e-43: 147: 100.00		PPIE_HUMAN (16-102): 3.37e-32: 122: 35.63
+	Hs
		1090322 ELAV2_HUMAN (1-195): 3.76e-37: 134: 15.79		PPIE_HUMAN (16-102): 3.37e-32: 122: 35.63
+	Hs
		1411462 PUF60_HUMAN (8-108): 8.36e-24: 100: 23.76		SRSF8_HUMAN (1-282): 5.36e-41: 144: 100.00
+	Xl
		1362166 ELAV2_XENLA (1-195): 5.63e-38: 137: 15.26		ELAV2_XENLA (10-92): 9.39e-24: 100: 25.00
+	Mm
		915306 SRSF2_MOUSE (1-221): 1.23e-43: 147: 100.00		TIA1_MOUSE (12-196): 1.11e-17: 83.7: 11.89
+	Hs
		1090216 ELAV2_HUMAN (1-195): 3.76e-37: 134: 15.79		PABP4_HUMAN (2-103): 3.84e-21: 94.8: 19.61
+	Hs
		550250 ELAV2_HUMAN (1-195): 3.76e-37: 134: 15.79		PABP1_HUMAN (2-103): 7.38e-20: 90.9: 18.63
+	At
		102912 F4JVB9_ARATH (17-76): 2.87e-25: 96.9: 38.33		RBG7_ARATH (8-91): 5.39e-29: 110: 34.52
+	Hs
		1102128 PUF60_HUMAN (8-108): 8.36e-24: 100: 23.76		PABP4_HUMAN (2-103): 3.84e-21: 94.8: 19.61
+	Hs
		550262 PABP4_HUMAN (5-191): 3.38e-24: 101: 13.37		PABP1_HUMAN (2-103): 7.38e-20: 90.9: 18.63
+	Hs
		550508 PUF60_HUMAN (8-108): 8.36e-24: 100: 23.76		PABP1_HUMAN (2-103): 7.38e-20: 90.9: 18.63
+	Hs
		506127 PAB4L_HUMAN (15-92): 8.6e-21: 90.9: 26.92		ELAV2_HUMAN (2-99): 4.96e-23: 98.6: 22.45
+	Hs
		1102095 PABP4_HUMAN (5-191): 3.38e-24: 101: 13.37		PABP3_HUMAN (2-103): 9.15e-19: 87.9: 19.61
+	Dm
		1303439 Q9VAX3_DROME (14-102): 1.14e-27: 111: 30.34		Q8IMX4_DROME (13-96): 4.22e-15: 76.8: 18.82
+	Zm
		8282 A0A1D6ELH4_MAIZE (12-153): 1.21e-24: 103: 19.72		A0A1D6ELH4_MAIZE (12-103): 2.06e-16: 80.9: 19.57
+	Zm
		10203 A0A1D6F1Z3_MAIZE (5-106): 2.84e-25: 101: 47.06		A0A1D6PN12_MAIZE (12-248): 2.97e-17: 81.5: 27.85