Protein: SRSF2
Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)

Gene: SRSF2
Organism: Homo sapiens
Interactions: 212
UniProt ID: Q01130

Gene Ontology (top 5):
GO:0000381 - regulation of alternative mRNA splicing, via spliceosome
GO:0003714 - transcription corepressor activity
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1006341

SRPK2
SRSF protein kinase 2

5

20

Small-scale

0.924

High

1029528

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

2

11

Small-scale

0.807

High

1029457

SRSF4
Serine/arginine-rich splicing factor 4

2

20

High-throughput

0.775

High

1028624

U2AF1
Splicing factor U2AF 35 kDa subunit

2

1

Small-scale

0.768

High

1029456

SRSF1
Serine/arginine-rich splicing factor 1

2

20

Small-scale

0.757

High

1029545

SRSF8
Serine/arginine-rich splicing factor 8

2

18

High-throughput

0.754

High

436657

KPCB
Protein kinase C beta type

2

5

High-throughput

0.737

High

1029475

KPCD1
Serine/threonine-protein kinase D1

2

8

High-throughput

0.737

High

1029490

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

7

High-throughput

0.737

High

997648

CSK21
Casein kinase II subunit alpha

1

7

High-throughput

0.710

High

1025323

CDK6
Cyclin-dependent kinase 6

1

3

Small-scale

0.710

High

853777

MK09
Mitogen-activated protein kinase 9

1

12

High-throughput

0.691

High

908958

NEK4
Serine/threonine-protein kinase Nek4

1

5

High-throughput

0.691

High

930676

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

High-throughput

0.691

High

1029469

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

2

High-throughput

0.691

High

1029482

MK14
Mitogen-activated protein kinase 14

1

12

High-throughput

0.691

High

1029540

SRPK1
SRSF protein kinase 1

1

20

High-throughput

0.691

High

1029574

SRPK3
SRSF protein kinase 3

1

20

High-throughput

0.691

High

231132

AIRE
Autoimmune regulator

1

14

Small-scale

0.665

High

1029476

RNPS1
RNA-binding protein with serine-rich domain 1

1

19

High-throughput

0.665

High

988088

TRA2B
Transformer-2 protein homolog beta

1

20

High-throughput

0.656

High

1016401

SRSF3
Serine/arginine-rich splicing factor 3

1

20

High-throughput

0.656

High

1029452

SRSF2
Serine/arginine-rich splicing factor 2

1

17

High-throughput

0.656

High

395930

ESR1
Estrogen receptor

3

20

High-throughput

0.650

High

1029529

ESR2
Estrogen receptor beta

3

20

High-throughput

0.624

High

1029455

SRS11
Serine/arginine-rich splicing factor 11

1

5

Small-scale

0.621

High

1029565

CEP72
Centrosomal protein of 72 kDa

1

6

High-throughput

0.621

High

134685

SAP18
Histone deacetylase complex subunit SAP18

1

4

High-throughput

0.618

High

157252

CTRO
Citron Rho-interacting kinase

1

13

High-throughput

0.618

High

172709

XPO1
Exportin-1

1

8

High-throughput

0.618

High

400668

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

11

High-throughput

0.618

High

472656

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

17

High-throughput

0.618

High

620302

NUCL
Nucleolin

1

16

Small-scale

0.618

High

685512

U2AF2
Splicing factor U2AF 65 kDa subunit

1

20

High-throughput

0.618

High

961002

MGN
Protein mago nashi homolog

1

1

High-throughput

0.618

High

1029453

EWS
RNA-binding protein EWS

1

15

High-throughput

0.618

High

1029463

SRSF5
Serine/arginine-rich splicing factor 5

1

20

High-throughput

0.618

High

1029472

RBM39
RNA-binding protein 39

1

19

High-throughput

0.618

High

1029478

SF3A2
Splicing factor 3A subunit 2

1

6

High-throughput

0.618

High

1029483

SRSF7
Serine/arginine-rich splicing factor 7

1

20

High-throughput

0.618

High

1029486

LARP7
La-related protein 7

1

20

High-throughput

0.618

High

1029505

CNTRL
Centriolin

1

2

High-throughput

0.618

High

1029507

THOC4
THO complex subunit 4

1

19

Small-scale

0.618

High

1029514

YAF2
YY1-associated factor 2

1

2

High-throughput

0.618

High

1029554

RC3H2
Roquin-2

1

16

High-throughput

0.618

High

1029568

KS6B2
Ribosomal protein S6 kinase beta-2

1

8

Small-scale

0.618

High

1029570

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.618

High

1029573

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

4

High-throughput

0.618

High

1029468

CUL3
Cullin-3

2

20

High-throughput

0.611

High

1029555

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

2

5

High-throughput

0.611

High

1029462

PAK1
Serine/threonine-protein kinase PAK 1

1

8

Small-scale

0.590

High

1029566

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

0

Small-scale

0.586

High

1029531

KAT5
Histone acetyltransferase KAT5

1

1

Small-scale

0.586

High

259809

BRD4
Bromodomain-containing protein 4

2

8

High-throughput

0.584

High

371789

MYC
Myc proto-oncogene protein

2

16

High-throughput

0.584

High

1029459

NCBP1
Nuclear cap-binding protein subunit 1

1

3

High-throughput

0.575

High

1029511

CIR1
Corepressor interacting with RBPJ 1

1

1

Small-scale

0.573

High

1029517

SH2D3
SH2 domain-containing protein 3C

2

11

High-throughput

0.571

High

1029560

RHG35
Rho GTPase-activating protein 35

2

5

High-throughput

0.571

High

1029461

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

3

High-throughput

0.553

High

1029503

PAXI1
PAX-interacting protein 1

1

11

High-throughput

0.552

High

337337

PARN
Poly(A)-specific ribonuclease PARN

1

1

High-throughput

0.536

High

346631

TTC4
Tetratricopeptide repeat protein 4

1

8

High-throughput

0.536

High

619028

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

1

High-throughput

0.536

High

807379

IF4A3
Eukaryotic initiation factor 4A-III

1

20

High-throughput

0.536

High

822137

PSB10
Proteasome subunit beta type-10

1

1

High-throughput

0.536

High

908379

HDGF
Hepatoma-derived growth factor

1

3

High-throughput

0.536

High

1029465

SNW1
SNW domain-containing protein 1

1

5

High-throughput

0.536

High

1029466

CUL1
Cullin-1

1

20

High-throughput

0.536

High

1029467

CUL2
Cullin-2

1

20

High-throughput

0.536

High

1029479

NEDD8
Ubiquitin-like protein NEDD8

1

2

High-throughput

0.536

High

1029506

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

5

High-throughput

0.536

High

1029508

ZCH18
Zinc finger CCCH domain-containing protein 18

1

12

High-throughput

0.536

High

1029509

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

12

High-throughput

0.536

High

1029530

CSN5
COP9 signalosome complex subunit 5

1

9

High-throughput

0.536

High

1029532

CUL5
Cullin-5

1

20

High-throughput

0.536

High

1029535

SAHH3
Adenosylhomocysteinase 3

1

1

High-throughput

0.536

High

1029541

CDC5L
Cell division cycle 5-like protein

1

7

Small-scale

0.536

High

881765

DHYS
Deoxyhypusine synthase

1

0

High-throughput

0.513

High

1029521

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.513

High

1029556

MOG1
Ran guanine nucleotide release factor

1

0

High-throughput

0.513

High

1029561

MA2C1
Alpha-mannosidase 2C1

1

0

High-throughput

0.513

High

1029564

PNPO
Pyridoxine-5'-phosphate oxidase

1

0

High-throughput

0.513

High

1029576

KLH20
Kelch-like protein 20

1

0

High-throughput

0.513

High

1029559

UBQL4
Ubiquilin-4

1

11

High-throughput

0.508

High

1029493

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

4

High-throughput

0.489

High

321501

PRP6
Pre-mRNA-processing factor 6

1

11

High-throughput

0.481

High

571929

TRI27
Zinc finger protein RFP

1

5

High-throughput

0.481

High

572808

NCF1
Neutrophil cytosol factor 1

1

11

Small-scale

0.481

High

587049

ITF2
Transcription factor 4

1

2

High-throughput

0.481

High

1029477

K1H1
Keratin, type I cuticular Ha1

1

4

High-throughput

0.481

High

1029495

K1C40
Keratin, type I cytoskeletal 40

1

4

High-throughput

0.481

High

1029537

DMRTB
Doublesex- and mab-3-related transcription factor B1

1

2

High-throughput

0.481

High

1029543

BARD1
BRCA1-associated RING domain protein 1

1

5

High-throughput

0.481

High

1029544

LZTS2
Leucine zipper putative tumor suppressor 2

1

17

High-throughput

0.481

High

1029563

UBP40
Ubiquitin carboxyl-terminal hydrolase 40

1

6

Small-scale

0.481

High

123665

MYO1C
Unconventional myosin-Ic

1

2

High-throughput

0.479

High

128978

MEN1
Menin

1

5

High-throughput

0.479

High

131964

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

High-throughput

0.479

High

222951

PRC1
Protein regulator of cytokinesis 1

1

9

High-throughput

0.479

High

241424

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.479

High

272085

OBSL1
Obscurin-like protein 1

1

6

High-throughput

0.479

High

285222

EED
Polycomb protein EED

1

12

High-throughput

0.479

High

319682

UFL1
E3 UFM1-protein ligase 1

1

5

High-throughput

0.479

High

324803

HEXI1
Protein HEXIM1

1

6

High-throughput

0.479

High

325791

UBR5
E3 ubiquitin-protein ligase UBR5

1

10

High-throughput

0.479

High

330878

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

335098

ARI2
E3 ubiquitin-protein ligase ARIH2

1

17

High-throughput

0.479

High

349953

SNAI1
Zinc finger protein SNAI1

1

3

High-throughput

0.479

High

363141

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

406078

MYCN
N-myc proto-oncogene protein

1

16

High-throughput

0.479

High

487201

PARP1
Poly [ADP-ribose] polymerase 1

1

5

High-throughput

0.479

High

606641

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.479

High

629791

BTF3
Transcription factor BTF3

1

2

High-throughput

0.479

High

730518

1433S
14-3-3 protein sigma

1

16

Small-scale

0.479

High

754805

H2B1B
Histone H2B type 1-B

1

3

High-throughput

0.479

High

766462

PHB1
Prohibitin 1

1

9

High-throughput

0.479

High

786548

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

7

High-throughput

0.479

High

830581

CCNF
Cyclin-F

1

7

High-throughput

0.479

High

856643

BAG6
Large proline-rich protein BAG6

1

9

High-throughput

0.479

High

862045

YAP1
Transcriptional coactivator YAP1

1

13

Small-scale

0.479

High

878977

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

8

High-throughput

0.479

High

904611

MECP2
Methyl-CpG-binding protein 2

1

8

High-throughput

0.479

High

970351

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

971415

1433E
14-3-3 protein epsilon

1

3

Small-scale

0.479

High

979512

H4
Histone H4

1

4

High-throughput

0.479

High

980701

H2B1C
Histone H2B type 1-C/E/F/G/I

1

3

High-throughput

0.479

High

1024511

VIGLN
Vigilin

1

20

High-throughput

0.479

High

1026319

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

1029454

KIF23
Kinesin-like protein KIF23

1

20

High-throughput

0.479

High

1029460

EP300
Histone acetyltransferase p300

1

5

High-throughput

0.479

High

1029464

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

1029470

TRI14
Tripartite motif-containing protein 14

1

9

High-throughput

0.479

High

1029473

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1029474

KIF14
Kinesin-like protein KIF14

1

10

High-throughput

0.479

High

1029481

EZH2
Histone-lysine N-methyltransferase EZH2

1

6

High-throughput

0.479

High

1029484

TECT1
Tectonic-1

1

1

High-throughput

0.479

High

1029488

DCAF6
DDB1- and CUL4-associated factor 6

1

7

High-throughput

0.479

High

1029491

RC3H1
Roquin-1

1

12

High-throughput

0.479

High

1029494

FTM
Protein fantom

1

13

High-throughput

0.479

High

1029497

TECT3
Tectonic-3

1

1

High-throughput

0.479

High

1029498

PRP8
Pre-mRNA-processing-splicing factor 8

1

3

High-throughput

0.479

High

1029504

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

High-throughput

0.479

High

1029512

CUL9
Cullin-9

1

13

High-throughput

0.479

High

1029513

SMC5
Structural maintenance of chromosomes protein 5

1

6

High-throughput

0.479

High

1029515

SRRM1
Serine/arginine repetitive matrix protein 1

1

8

High-throughput

0.479

High

1029518

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

3

High-throughput

0.479

High

1029522

TNIP2
TNFAIP3-interacting protein 2

1

4

High-throughput

0.479

High

1029525

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

5

High-throughput

0.479

High

1029526

FBF1
Fas-binding factor 1

1

11

High-throughput

0.479

High

1029533

FBXW7
F-box/WD repeat-containing protein 7

1

10

High-throughput

0.479

High

1029538

SCLT1
Sodium channel and clathrin linker 1

1

9

High-throughput

0.479

High

1029542

SORT
Sortilin

1

1

High-throughput

0.479

High

1029546

RIOK1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

1029547

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.479

High

1029549

TRI31
E3 ubiquitin-protein ligase TRIM31

1

19

High-throughput

0.479

High

1029552

ECT2
Protein ECT2

1

9

High-throughput

0.479

High

1029557

BRD7
Bromodomain-containing protein 7

1

9

High-throughput

0.479

High

1029558

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

4

High-throughput

0.479

High

1029567

HDAC6
Protein deacetylase HDAC6

1

8

Small-scale

0.479

High

1029569

NXF1
Nuclear RNA export factor 1

1

3

Small-scale

0.479

High

1029575

CE164
Centrosomal protein of 164 kDa

1

9

High-throughput

0.479

High

1029578

TRRAP
Transformation/transcription domain-associated protein

1

4

High-throughput

0.479

High

1029579

MAFB
Transcription factor MafB

1

7

High-throughput

0.479

High

892668

DNLI4
DNA ligase 4

1

0

High-throughput

0.460

High

184283

NPHP1
Nephrocystin-1

1

0

High-throughput

0.458

High

289976

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

341929

CEP43
Centrosomal protein 43

1

0

High-throughput

0.458

High

378485

IL1A
Interleukin-1 alpha

1

0

Small-scale

0.458

High

762301

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

851522

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.458

High

1029471

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.458

High

1029487

MIDN
Midnolin

1

0

High-throughput

0.458

High

1029492

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

429744

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

529647

TAU
Microtubule-associated protein tau

1

14

High-throughput

0.445

High

765401

BMI1
Polycomb complex protein BMI-1

1

16

High-throughput

0.445

High

952110

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

961159

FGF12
Fibroblast growth factor 12

1

1

Small-scale

0.445

High

1029489

ODFP2
Outer dense fiber protein 2

1

3

High-throughput

0.445

High

1029510

S2611
Sodium-independent sulfate anion transporter

1

2

High-throughput

0.445

High

1029539

CCNL2
Cyclin-L2

1

8

Small-scale

0.445

High

1029551

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

20

High-throughput

0.445

High

1029571

DDX41
Probable ATP-dependent RNA helicase DDX41

1

10

High-throughput

0.445

High

1029572

CCNL1
Cyclin-L1

1

6

Small-scale

0.445

High

1029458

GOGA2
Golgin subfamily A member 2

1

10

High-throughput

0.439

High

282462

KTNA1
Katanin p60 ATPase-containing subunit A1

1

4

High-throughput

0.437

High

411754

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.437

High

590878

TIMP2
Metalloproteinase inhibitor 2

1

1

High-throughput

0.437

High

1029499

SAS6
Spindle assembly abnormal protein 6 homolog

1

1

High-throughput

0.437

High

1029500

TBCD9
TBC1 domain family member 9

1

1

High-throughput

0.437

High

1029501

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

1029502

CE128
Centrosomal protein of 128 kDa

1

11

High-throughput

0.437

High

1029520

POC5
Centrosomal protein POC5

1

3

High-throughput

0.437

High

1029523

TIP
T-cell immunomodulatory protein

1

4

High-throughput

0.437

High

1029524

POC1B
POC1 centriolar protein homolog B

1

5

High-throughput

0.437

High

1029527

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

1

High-throughput

0.437

High

1029536

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.437

High

1029548

RHBT2
Rho-related BTB domain-containing protein 2

1

6

High-throughput

0.437

High

1029577

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

775650

DEK
Protein DEK

1

0

Small-scale

0.426

High

62488

S35F4
Solute carrier family 35 member F4

1

1

High-throughput

0.407

High

1029553

GHC1
Mitochondrial glutamate carrier 1

1

3

High-throughput

0.407

High

1029496

K0930
Uncharacterized protein KIAA0930

1

0

High-throughput

0.279

Low

1029516

THNS1
Threonine synthase-like 1

1

0

High-throughput

0.279

Low

1029534

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.279

Low

1029550

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.279

Low

1029562

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

0

High-throughput

0.279

Low

1029485

CCD14
Coiled-coil domain-containing protein 14

1

0

High-throughput

0.249

Low

1029480

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low

1029519

S35G3
Solute carrier family 35 member G3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025