Protein: SRSF8
Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B)

Gene: SRSF8
Organism: Homo sapiens
Interactions: 101
UniProt ID: Q9BRL6

Gene Ontology (top 5):
GO:0000381 - regulation of alternative mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006397 - mRNA processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1006662

SRPK2
SRSF protein kinase 2

5

19

High-throughput

0.939

High

889799

CLK3
Dual specificity protein kinase CLK3

5

14

High-throughput

0.927

High

1360234

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

4

13

Small-scale

0.897

High

889645

CLK2
Dual specificity protein kinase CLK2

3

14

High-throughput

0.863

High

473026

RU17
U1 small nuclear ribonucleoprotein 70 kDa

3

17

High-throughput

0.861

High

1111853

TRA2A
Transformer-2 protein homolog alpha

3

19

High-throughput

0.861

High

1090289

ELAV2
ELAV-like protein 2

2

19

High-throughput

0.811

High

988200

TRA2B
Transformer-2 protein homolog beta

2

19

High-throughput

0.783

High

1016587

SRSF3
Serine/arginine-rich splicing factor 3

2

20

High-throughput

0.783

High

1402548

SRPK1
SRSF protein kinase 1

1

20

High-throughput

0.778

High

1029545

SRSF2
Serine/arginine-rich splicing factor 2

2

18

High-throughput

0.754

High

1411467

LC7L2
Putative RNA-binding protein Luc7-like 2

4

7

High-throughput

0.695

High

134845

SAP18
Histone deacetylase complex subunit SAP18

1

3

High-throughput

0.691

High

462600

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

20

High-throughput

0.691

High

685705

U2AF2
Splicing factor U2AF 65 kDa subunit

1

20

High-throughput

0.691

High

1009300

PRR3
Proline-rich protein 3

1

2

High-throughput

0.691

High

1062095

SRSF4
Serine/arginine-rich splicing factor 4

1

20

High-throughput

0.691

High

1099222

SRSF5
Serine/arginine-rich splicing factor 5

1

20

High-throughput

0.691

High

1099504

SRSF6
Serine/arginine-rich splicing factor 6

1

20

High-throughput

0.691

High

1160056

SRSF7
Serine/arginine-rich splicing factor 7

1

20

High-throughput

0.691

High

1365659

LAR4B
La-related protein 4B

1

20

High-throughput

0.691

High

1387883

PABP5
Polyadenylate-binding protein 5

1

18

High-throughput

0.691

High

1411462

PUF60
Poly(U)-binding-splicing factor PUF60

1

19

High-throughput

0.691

High

1411464

RALY
RNA-binding protein Raly

1

12

High-throughput

0.691

High

1411468

RBMX2
RNA-binding motif protein, X-linked 2

1

19

High-throughput

0.691

High

1290685

ZCH18
Zinc finger CCCH domain-containing protein 18

3

11

High-throughput

0.667

High

1346904

SNIP1
Smad nuclear-interacting protein 1

3

1

High-throughput

0.667

High

1049721

1433F
14-3-3 protein eta

3

19

High-throughput

0.662

High

872010

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

2

3

High-throughput

0.628

High

1411447

NXF2
Nuclear RNA export factor 2

2

5

High-throughput

0.628

High

478183

SNRPA
U1 small nuclear ribonucleoprotein A

1

20

High-throughput

0.621

High

157789

CTRO
Citron Rho-interacting kinase

1

12

High-throughput

0.618

High

401391

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

12

High-throughput

0.618

High

615586

NELFE
Negative elongation factor E

1

11

High-throughput

0.618

High

961100

MGN
Protein mago nashi homolog

1

3

High-throughput

0.618

High

1197554

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

9

High-throughput

0.618

High

1411461

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.618

High

422999

A4
Amyloid-beta precursor protein

2

3

High-throughput

0.602

High

966814

1433G
14-3-3 protein gamma

2

19

High-throughput

0.601

High

1411453

LUC7L
Putative RNA-binding protein Luc7-like 1

3

7

High-throughput

0.600

High

948379

KR122
Keratin-associated protein 12-2

2

0

High-throughput

0.580

High

1256723

NKAP1
Uncharacterized protein NKAPD1

2

1

High-throughput

0.574

High

1338514

DOCK8
Dedicator of cytokinesis protein 8

2

2

High-throughput

0.571

High

889491

CLK1
Dual specificity protein kinase CLK1

1

14

High-throughput

0.555

High

272994

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

2

High-throughput

0.536

High

480289

RU1C
U1 small nuclear ribonucleoprotein C

1

4

High-throughput

0.536

High

809811

RS19
Small ribosomal subunit protein eS19

1

1

High-throughput

0.536

High

854264

KI67
Proliferation marker protein Ki-67

1

7

High-throughput

0.536

High

905082

MECP2
Methyl-CpG-binding protein 2

1

6

High-throughput

0.536

High

960861

RL15
Large ribosomal subunit protein eL15

1

4

High-throughput

0.536

High

990672

1433Z
14-3-3 protein zeta/delta

1

19

High-throughput

0.536

High

1008862

RED1
Double-stranded RNA-specific editase 1

1

9

High-throughput

0.536

High

1015294

ERH
Enhancer of rudimentary homolog

1

1

High-throughput

0.536

High

1102242

ATM
Serine-protein kinase ATM

1

4

High-throughput

0.536

High

1168877

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

5

High-throughput

0.536

High

1191473

GRDN
Girdin

1

9

High-throughput

0.536

High

1411457

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

5

High-throughput

0.536

High

1411466

TR150
Thyroid hormone receptor-associated protein 3

1

6

High-throughput

0.536

High

1411469

CCDC9
Coiled-coil domain-containing protein 9

1

1

High-throughput

0.536

High

1233936

Q6ICH2
single-stranded DNA cytosine deaminase

2

11

High-throughput

0.533

High

1137491

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.515

High

508528

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

13

High-throughput

0.501

High

191781

MAGB2
Melanoma-associated antigen B2

1

4

High-throughput

0.489

High

321651

PRP6
Pre-mRNA-processing factor 6

1

15

High-throughput

0.481

High

895958

F10A1
Hsc70-interacting protein

1

2

High-throughput

0.481

High

1214664

RBM26
RNA-binding protein 26

1

4

High-throughput

0.481

High

1411455

4ET
Eukaryotic translation initiation factor 4E transporter

1

1

High-throughput

0.481

High

1411459

NXF1
Nuclear RNA export factor 1

1

5

High-throughput

0.481

High

223292

PRC1
Protein regulator of cytokinesis 1

1

6

High-throughput

0.479

High

285441

EED
Polycomb protein EED

1

10

High-throughput

0.479

High

331271

KI20A
Kinesin-like protein KIF20A

1

17

High-throughput

0.479

High

730859

1433S
14-3-3 protein sigma

1

20

Small-scale

0.479

High

879405

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.479

High

948923

CD81
CD81 antigen

1

2

High-throughput

0.479

High

980227

H4
Histone H4

1

5

High-throughput

0.479

High

1024803

VIGLN
Vigilin

1

20

High-throughput

0.479

High

1035875

KIF23
Kinesin-like protein KIF23

1

13

High-throughput

0.479

High

1328931

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

3

High-throughput

0.479

High

1360813

ASB11
Ankyrin repeat and SOCS box protein 11

1

4

High-throughput

0.479

High

1396784

SNX27
Sorting nexin-27

1

4

High-throughput

0.479

High

1411449

ECT2
Protein ECT2

1

6

High-throughput

0.479

High

1411451

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

2

High-throughput

0.479

High

1411454

ANLN
Anillin

1

5

High-throughput

0.479

High

1411465

FBW1A
F-box/WD repeat-containing protein 1A

1

9

High-throughput

0.479

High

1234220

SNR48
U11/U12 small nuclear ribonucleoprotein 48 kDa protein

1

0

High-throughput

0.460

High

1332838

PR38A
Pre-mRNA-splicing factor 38A

1

0

High-throughput

0.460

High

1411450

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

1411452

NGB
Neuroglobin

1

0

High-throughput

0.458

High

1411456

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

807556

IF4A3
Eukaryotic initiation factor 4A-III

1

20

High-throughput

0.445

High

1383326

ABC3D
DNA dC->dU-editing enzyme APOBEC-3D

1

11

High-throughput

0.445

High

1411463

DDX41
Probable ATP-dependent RNA helicase DDX41

1

14

High-throughput

0.445

High

1411446

WDR83
WD repeat domain-containing protein 83

1

12

High-throughput

0.439

High

1380584

IGSF8
Immunoglobulin superfamily member 8

1

7

High-throughput

0.437

High

1411448

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.437

High

73442

B2CML4
single-stranded DNA cytosine deaminase

1

11

High-throughput

0.407

High

1411458

I36RA
Interleukin-36 receptor antagonist protein

2

0

High-throughput

0.328

High

907688

CLCN2
Chloride channel protein 2

1

0

High-throughput

0.279

Low

1411460

ZBT47
Zinc finger and BTB domain-containing protein 47

1

0

High-throughput

0.279

Low

583333

FOLR1
Folate receptor alpha

1

0

High-throughput

0.249

Low

1115

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025