Interactor 1: RUNX1 (Q01196)
Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit)
Gene: RUNX1
Interactor 2: PEBB (Q13951)
Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit)
Gene: CBFB
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 1.00 | 0.988 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 23333304, 32296183, 31253590, 33961781, 34591612, 20195544, 14752096, 26598521, 28536267, 10856244, 35914814, 37500075, 11742995, 14729951, 22498736, 15331439, 25678665, 2845103, unassigned1304, 31048839 and 1 others
more... |
| Identification Methods | biochemical, affinity chromatography technology, two hybrid, pull down, x-ray crystallography, anti bait coimmunoprecipitation, two hybrid array, two hybrid prey pooling approach, anti tag coimmunoprecipitation, isothermal titration calorimetry and 2 others
more... |
| Interaction Type | association, physical association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | CBF_beta~Runt |
| Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0016513 - core-binding factor complex GO:0030099 - myeloid cell differentiation and 3 others more... |
| Homologous interactions | 8 |
Homologous interactions
Color coding for hit scores 
|
|
|||||||||||||
| + | Mm |   |
|
|||||||||||
| + | Rn | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Mm | |
|
|||||||||||
| + | Dm | |
|
|||||||||||
| + | Dm | |
|
|||||||||||
| + | Dm | |
|
|||||||||||
Service provided by Combinatics, Japan
Last updated: 11Aug2025
