Protein: HMGB2
High mobility group protein B2 (High mobility group protein 2) (HMG-2)

Gene: HMGB2
Organism: Homo sapiens
Interactions: 243
UniProt ID: P26583

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000400 - four-way junction DNA binding
GO:0000785 - chromatin
GO:0000793 - condensed chromosome
GO:0000976 - transcription cis-regulatory region binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

449550

HMGB1
High mobility group protein B1

5

14

Small-scale

0.915

High

617247

SP100
Nuclear autoantigen Sp-100

2

18

High-throughput

0.789

High

447470

PO2F2
POU domain, class 2, transcription factor 2

1

20

Small-scale

0.692

High

643279

PKNX1
Homeobox protein PKNOX1

4

11

High-throughput

0.683

High

625125

CDK2
Cyclin-dependent kinase 2

3

9

High-throughput

0.656

High

643407

NOP53
Ribosome biogenesis protein NOP53

2

2

Small-scale

0.643

High

597966

FLNA
Filamin-A

2

9

Small-scale

0.625

High

643306

RS28
Small ribosomal subunit protein eS28

2

1

Small-scale

0.625

High

643397

MIEN1
Migration and invasion enhancer 1

3

1

Small-scale

0.619

High

175750

HMGB3
High mobility group protein B3

1

13

High-throughput

0.618

High

643250

CTNB1
Catenin beta-1

1

15

High-throughput

0.618

High

643330

PO5F1
POU domain, class 5, transcription factor 1

1

20

Small-scale

0.618

High

643255

RL3
Large ribosomal subunit protein uL3

2

3

High-throughput

0.611

High

643271

RL14
Large ribosomal subunit protein eL14

2

2

High-throughput

0.611

High

643294

RS16
Small ribosomal subunit protein uS9

2

6

High-throughput

0.611

High

643323

RL24
Large ribosomal subunit protein eL24

2

2

High-throughput

0.611

High

643370

COMD1
COMM domain-containing protein 1

2

1

Small-scale

0.603

High

643386

ZN668
Zinc finger protein 668

2

3

Small-scale

0.603

High

519845

GRAA
Granzyme A

2

5

Small-scale

0.602

High

643383

ZN428
Zinc finger protein 428

3

1

Small-scale

0.596

High

643335

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

2

5

Small-scale

0.595

High

243964

BRD4
Bromodomain-containing protein 4

2

20

High-throughput

0.584

High

643301

H4
Histone H4

2

13

High-throughput

0.584

High

643302

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.584

High

643392

TSNAX
Translin-associated protein X

2

0

High-throughput

0.580

High

643327

U2AF1
Splicing factor U2AF 35 kDa subunit

2

0

Small-scale

0.577

High

408558

KPCB
Protein kinase C beta type

2

12

High-throughput

0.571

High

643331

OCRL
Inositol polyphosphate 5-phosphatase OCRL

2

1

High-throughput

0.571

High

643396

SH3G3
Endophilin-A3

2

6

High-throughput

0.571

High

643339

CAF1A
Chromatin assembly factor 1 subunit A

1

7

Small-scale

0.561

High

564805

HMGA1
High mobility group protein HMG-I/HMG-Y

1

3

Small-scale

0.550

High

643266

KC1A
Casein kinase I isoform alpha

1

7

Small-scale

0.543

High

78276

EIFCL
Eukaryotic translation initiation factor 3 subunit C-like protein

1

2

High-throughput

0.536

High

117593

MYO1C
Unconventional myosin-Ic

1

5

High-throughput

0.536

High

201223

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

2

High-throughput

0.536

High

283395

SRP72
Signal recognition particle subunit SRP72

1

2

High-throughput

0.536

High

362838

FINC
Fibronectin

1

3

High-throughput

0.536

High

400234

RLA1
Large ribosomal subunit protein P1

1

1

High-throughput

0.536

High

400457

RLA2
Large ribosomal subunit protein P2

1

3

High-throughput

0.536

High

400756

RLA0
Large ribosomal subunit protein uL10

1

6

High-throughput

0.536

High

445285

RSSA
Small ribosomal subunit protein uS2

1

8

High-throughput

0.536

High

455110

PARP1
Poly [ADP-ribose] polymerase 1

1

17

High-throughput

0.536

High

516365

PABP1
Polyadenylate-binding protein 1

1

6

High-throughput

0.536

High

550615

RS2
Small ribosomal subunit protein uS5

1

6

High-throughput

0.536

High

577808

RL17
Large ribosomal subunit protein uL22

1

1

High-throughput

0.536

High

643244

RL10
Large ribosomal subunit protein uL16

1

4

High-throughput

0.536

High

643251

RL22
Large ribosomal subunit protein eL22

1

2

High-throughput

0.536

High

643252

RL4
Large ribosomal subunit protein uL4

1

5

High-throughput

0.536

High

643254

RS19
Small ribosomal subunit protein eS19

1

5

High-throughput

0.536

High

643257

RS27
Small ribosomal subunit protein eS27

1

1

High-throughput

0.536

High

643258

RL35
Large ribosomal subunit protein uL29

1

2

High-throughput

0.536

High

643260

RL27A
Large ribosomal subunit protein uL15

1

3

High-throughput

0.536

High

643261

RL21
Large ribosomal subunit protein eL21

1

2

High-throughput

0.536

High

643263

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

12

High-throughput

0.536

High

643265

PRC2A
Protein PRRC2A

1

20

High-throughput

0.536

High

643267

RL34
Large ribosomal subunit protein eL34

1

2

High-throughput

0.536

High

643283

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

1

High-throughput

0.536

High

643285

RS20
Small ribosomal subunit protein uS10

1

6

High-throughput

0.536

High

643286

SRP54
Signal recognition particle subunit SRP54

1

1

High-throughput

0.536

High

643287

ABCE1
ATP-binding cassette sub-family E member 1

1

4

High-throughput

0.536

High

643289

RL27
Large ribosomal subunit protein eL27

1

6

High-throughput

0.536

High

643291

RS7
Small ribosomal subunit protein eS7

1

2

High-throughput

0.536

High

643292

RS8
Small ribosomal subunit protein eS8

1

3

High-throughput

0.536

High

643293

RS15A
Small ribosomal subunit protein uS8

1

6

High-throughput

0.536

High

643296

RS23
Small ribosomal subunit protein uS12

1

5

High-throughput

0.536

High

643297

RS18
Small ribosomal subunit protein uS13

1

3

High-throughput

0.536

High

643298

RS4X
Small ribosomal subunit protein eS4, X isoform

1

6

High-throughput

0.536

High

643299

RL23A
Large ribosomal subunit protein uL23

1

3

High-throughput

0.536

High

643300

RS6
Small ribosomal subunit protein eS6

1

5

High-throughput

0.536

High

643303

RS15
Small ribosomal subunit protein uS19

1

5

High-throughput

0.536

High

643304

RS25
Small ribosomal subunit protein eS25

1

1

High-throughput

0.536

High

643308

RL39
Large ribosomal subunit protein eL39

1

4

High-throughput

0.536

High

643309

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.536

High

643310

RL10A
Large ribosomal subunit protein uL1

1

6

High-throughput

0.536

High

643311

RL32
Large ribosomal subunit protein eL32

1

2

High-throughput

0.536

High

643312

RL11
Large ribosomal subunit protein uL5

1

3

High-throughput

0.536

High

643313

RL8
Large ribosomal subunit protein uL2

1

4

High-throughput

0.536

High

643315

RL38
Large ribosomal subunit protein eL38

1

1

High-throughput

0.536

High

643316

RS21
Small ribosomal subunit protein eS21

1

3

High-throughput

0.536

High

643318

RACK1
Small ribosomal subunit protein RACK1

1

20

High-throughput

0.536

High

643319

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.536

High

643334

KPCZ
Protein kinase C zeta type

1

15

High-throughput

0.536

High

643342

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

20

High-throughput

0.536

High

643346

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

17

High-throughput

0.536

High

643356

KDM4D
Lysine-specific demethylase 4D

1

4

High-throughput

0.536

High

643361

RS27L
Ribosomal protein eS27-like

1

1

High-throughput

0.536

High

643362

DHX30
ATP-dependent RNA helicase DHX30

1

10

High-throughput

0.536

High

643364

NUFP2
FMR1-interacting protein NUFIP2

1

3

High-throughput

0.536

High

643365

KTN1
Kinectin

1

5

High-throughput

0.536

High

643369

SYNPO
Synaptopodin

1

20

High-throughput

0.536

High

643371

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.536

High

643375

H1X
Histone H1.10

1

2

High-throughput

0.536

High

643377

MY18A
Unconventional myosin-XVIIIa

1

4

High-throughput

0.536

High

643394

ATX2
Ataxin-2

1

17

High-throughput

0.536

High

643398

GNL3
Guanine nucleotide-binding protein-like 3

1

7

High-throughput

0.536

High

643399

LSG1
Large subunit GTPase 1 homolog

1

7

High-throughput

0.536

High

643402

WDR26
WD repeat-containing protein 26

1

20

High-throughput

0.536

High

643415

SRP68
Signal recognition particle subunit SRP68

1

1

High-throughput

0.536

High

643419

RL36
Large ribosomal subunit protein eL36

1

2

High-throughput

0.536

High

643341

CBLB
E3 ubiquitin-protein ligase CBL-B

1

11

High-throughput

0.515

High

643366

DZIP1
Cilium assembly protein DZIP1

1

7

High-throughput

0.515

High

643385

Q96I87
Homeobox-containing protein PKNOX1

1

11

High-throughput

0.515

High

398644

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

0

High-throughput

0.513

High

643305

RS26
Small ribosomal subunit protein eS26

1

0

High-throughput

0.513

High

643401

CCD86
Coiled-coil domain-containing protein 86

1

0

High-throughput

0.513

High

643413

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

High-throughput

0.513

High

643256

EIF1
Eukaryotic translation initiation factor 1

1

2

High-throughput

0.508

High

643278

NP1L1
Nucleosome assembly protein 1-like 1

1

9

High-throughput

0.508

High

643324

H33
Histone H3.3

1

20

High-throughput

0.508

High

643325

VIGLN
Vigilin

1

12

High-throughput

0.508

High

643343

ROCK1
Rho-associated protein kinase 1

1

13

Small-scale

0.508

High

643348

PCBP1
Poly(rC)-binding protein 1

1

9

Small-scale

0.508

High

643374

CATIN
Splicing factor Cactin

1

5

High-throughput

0.508

High

643387

ZFR
Zinc finger RNA-binding protein

1

9

Small-scale

0.508

High

643389

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

20

Small-scale

0.508

High

643411

BCCIP
BRCA2 and CDKN1A-interacting protein

1

1

Small-scale

0.508

High

643416

LZTS1
Leucine zipper putative tumor suppressor 1

1

10

High-throughput

0.508

High

377106

GCR
Glucocorticoid receptor

1

20

Small-scale

0.501

High

394149

A4
Amyloid-beta precursor protein

1

8

High-throughput

0.501

High

414441

PRGR
Progesterone receptor

1

20

Small-scale

0.501

High

487147

ANDR
Androgen receptor

1

20

Small-scale

0.501

High

551425

RAG1
V(D)J recombination-activating protein 1

1

16

Small-scale

0.501

High

643328

SET
Protein SET

1

9

Small-scale

0.501

High

643378

CBP
CREB-binding protein

1

20

Small-scale

0.501

High

643418

FBX7
F-box only protein 7

1

2

High-throughput

0.501

High

601460

FGFR2
Fibroblast growth factor receptor 2

1

15

High-throughput

0.500

High

643259

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.489

High

643273

SSRD
Translocon-associated protein subunit delta

1

1

High-throughput

0.489

High

643322

HTRA4
Serine protease HTRA4

1

2

High-throughput

0.489

High

643363

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

2

High-throughput

0.489

High

643367

MYLK4
Myosin light chain kinase family member 4

1

9

High-throughput

0.489

High

310907

SNAPN
SNARE-associated protein Snapin

1

0

Small-scale

0.486

High

643264

COPD
Coatomer subunit delta

1

0

High-throughput

0.486

High

643354

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.486

High

643382

ZN622
Cytoplasmic 60S subunit biogenesis factor ZNF622

1

0

High-throughput

0.486

High

643391

CRBN
Protein cereblon

1

0

Small-scale

0.480

High

121111

LEG8
Galectin-8

1

5

Small-scale

0.479

High

121939

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

2

Small-scale

0.479

High

179554

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

9

High-throughput

0.479

High

214855

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

2

High-throughput

0.479

High

239500

EIF1B
Eukaryotic translation initiation factor 1b

1

2

High-throughput

0.479

High

267901

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

272847

KS6A4
Ribosomal protein S6 kinase alpha-4

1

9

High-throughput

0.479

High

302930

HEXI1
Protein HEXIM1

1

5

High-throughput

0.479

High

329381

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.479

High

337963

EGFR
Epidermal growth factor receptor

1

9

High-throughput

0.479

High

345975

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

379037

MYCN
N-myc proto-oncogene protein

1

20

High-throughput

0.479

High

384301

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.479

High

414748

CDK1
Cyclin-dependent kinase 1

1

8

High-throughput

0.479

High

444837

ANXA5
Annexin A5

1

9

High-throughput

0.479

High

559561

H12
Histone H1.2

1

7

High-throughput

0.479

High

569219

CEBPB
CCAAT/enhancer-binding protein beta

1

20

High-throughput

0.479

High

587428

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

15

High-throughput

0.479

High

614244

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

8

High-throughput

0.479

High

641621

U2AF2
Splicing factor U2AF 65 kDa subunit

1

16

High-throughput

0.479

High

642185

RL13
Large ribosomal subunit protein eL13

1

3

High-throughput

0.479

High

643245

CALX
Calnexin

1

2

High-throughput

0.479

High

643246

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

9

High-throughput

0.479

High

643247

PDIA3
Protein disulfide-isomerase A3

1

4

High-throughput

0.479

High

643248

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.479

High

643249

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

1

High-throughput

0.479

High

643253

COIL
Coilin

1

3

High-throughput

0.479

High

643262

RS10
Small ribosomal subunit protein eS10

1

3

High-throughput

0.479

High

643268

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.479

High

643272

SMCA2
Probable global transcription activator SNF2L2

1

20

High-throughput

0.479

High

643274

KS6A3
Ribosomal protein S6 kinase alpha-3

1

9

High-throughput

0.479

High

643276

HMGA2
High mobility group protein HMGI-C

1

4

Small-scale

0.479

High

643277

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

4

High-throughput

0.479

High

643280

HDAC4
Histone deacetylase 4

1

18

High-throughput

0.479

High

643281

IF6
Eukaryotic translation initiation factor 6

1

1

High-throughput

0.479

High

643288

RS3A
Small ribosomal subunit protein eS1

1

7

High-throughput

0.479

High

643290

WDR5
WD repeat-containing protein 5

1

20

High-throughput

0.479

High

643295

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

643314

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

12

High-throughput

0.479

High

643317

IF5A1
Eukaryotic translation initiation factor 5A-1

1

3

High-throughput

0.479

High

643320

H31
Histone H3.1

1

20

High-throughput

0.479

High

643326

CDK5
Cyclin-dependent kinase 5

1

9

High-throughput

0.479

High

643329

TFAP4
Transcription factor AP-4

1

4

Small-scale

0.479

High

643332

H11
Histone H1.1

1

7

High-throughput

0.479

High

643333

RL6
Large ribosomal subunit protein eL6

1

3

High-throughput

0.479

High

643336

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

643338

FOXC1
Forkhead box protein C1

1

20

High-throughput

0.479

High

643340

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.479

High

643344

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

643345

DX39B
Spliceosome RNA helicase DDX39B

1

17

High-throughput

0.479

High

643347

TNIP1
TNFAIP3-interacting protein 1

1

13

High-throughput

0.479

High

643349

KS6A1
Ribosomal protein S6 kinase alpha-1

1

10

High-throughput

0.479

High

643350

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

High-throughput

0.479

High

643351

GLO2
Hydroxyacylglutathione hydrolase, mitochondrial

1

2

High-throughput

0.479

High

643353

LARP7
La-related protein 7

1

20

High-throughput

0.479

High

643357

H2A2A
Histone H2A type 2-A

1

20

High-throughput

0.479

High

643358

H3C
Histone H3.3C

1

20

High-throughput

0.479

High

643359

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.479

High

643360

H32
Histone H3.2

1

20

High-throughput

0.479

High

643368

SMC5
Structural maintenance of chromosomes protein 5

1

12

High-throughput

0.479

High

643372

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

643376

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

643379

GGH
Gamma-glutamyl hydrolase

1

1

High-throughput

0.479

High

643380

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.479

High

643381

LHX4
LIM/homeobox protein Lhx4

1

20

High-throughput

0.479

High

643395

H2A1J
Histone H2A type 1-J

1

20

High-throughput

0.479

High

643400

Q9H4D1
Protein kinase

1

6

High-throughput

0.479

High

643406

ANLN
Anillin

1

6

High-throughput

0.479

High

643408

PD1L1
Programmed cell death 1 ligand 1

1

4

High-throughput

0.479

High

643414

ZRAN1
Ubiquitin thioesterase ZRANB1

1

12

High-throughput

0.479

High

643417

TR150
Thyroid hormone receptor-associated protein 3

1

17

High-throughput

0.479

High

643420

TRAF6
TNF receptor-associated factor 6

1

17

High-throughput

0.479

High

643422

RT18B
Small ribosomal subunit protein mS40

1

3

High-throughput

0.479

High

643403

OTOF
Otoferlin

1

3

High-throughput

0.470

High

643284

MYL6
Myosin light polypeptide 6

1

5

Small-scale

0.464

High

643337

NEXN
Nexilin

1

5

High-throughput

0.464

High

643352

TBC25
TBC1 domain family member 25

1

2

Small-scale

0.464

High

643421

SAM50
Sorting and assembly machinery component 50 homolog

1

1

High-throughput

0.464

High

562877

STMN1
Stathmin

1

0

High-throughput

0.458

High

596458

PTMS
Parathymosin

1

0

High-throughput

0.458

High

643388

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

643270

GRAK
Granzyme K

1

5

Small-scale

0.457

High

643393

GFI1
Zinc finger protein Gfi-1

1

7

Small-scale

0.457

High

445824

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

12

High-throughput

0.457

High

643390

LMTK3
Serine/threonine-protein kinase LMTK3

1

18

High-throughput

0.457

High

90062

D6RAT0
Small ribosomal subunit protein eS1

1

7

High-throughput

0.445

High

101623

F8VR69
Ribosomal protein L6

1

3

High-throughput

0.445

High

110711

H3BUK8
Large ribosomal subunit protein eL13

1

2

High-throughput

0.445

High

330861

PAK4
Serine/threonine-protein kinase PAK 4

1

7

High-throughput

0.445

High

496347

TAU
Microtubule-associated protein tau

1

13

High-throughput

0.445

High

528587

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.445

High

581447

VCAM1
Vascular cell adhesion protein 1

1

5

High-throughput

0.445

High

643282

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

6

High-throughput

0.445

High

643307

RS30
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

1

2

High-throughput

0.445

High

643355

NOMO2
BOS complex subunit NOMO2

1

1

High-throughput

0.445

High

643384

OTUB1
Ubiquitin thioesterase OTUB1

1

1

High-throughput

0.445

High

643404

RS10L
Putative ribosomal protein eS10-like

1

3

High-throughput

0.445

High

66262

WASH1
WASH complex subunit 1

1

1

High-throughput

0.437

High

596191

NEBU
Nebulin

1

5

High-throughput

0.437

High

643275

CHIO
Beta-chimaerin

1

9

High-throughput

0.437

High

643321

NOMO3
BOS complex subunit NOMO3

1

1

High-throughput

0.437

High

643410

RHG23
Rho GTPase-activating protein 23

1

10

High-throughput

0.437

High

643269

CEBPA
CCAAT/enhancer-binding protein alpha

1

20

High-throughput

0.408

High

643405

WASH6
WAS protein family homolog 6

1

1

High-throughput

0.407

High

643373

PHOP1
Phosphoethanolamine/phosphocholine phosphatase

1

0

High-throughput

0.279

Low

643412

CFA97
Cilia- and flagella-associated protein 97

1

0

High-throughput

0.279

Low

643409

HACD3
Very-long-chain

1

0

High-throughput

0.265

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024