Protein: PEBB
Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit)

Gene: PEBB, CBFB
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q13951

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000209 - protein polyubiquitination
GO:0001649 - osteoblast differentiation
GO:0003713 - transcription coactivator activity
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1029829

RUNX1
Runt-related transcription factor 1

21

8

Small-scale

0.988

High

1117047

RUNX3
Runt-related transcription factor 3

6

8

Small-scale

0.942

High

1119467

RUNX2
Runt-related transcription factor 2

5

8

Small-scale

0.922

High

1119520

CUL5
Cullin-5

6

1

Small-scale

0.842

High

1119500

PEBB
Core-binding factor subunit beta

2

1

High-throughput

0.754

High

577437

ETS1
Protein C-ets-1

1

1

High-throughput

0.618

High

1112829

CUL2
Cullin-2

1

1

High-throughput

0.618

High

1119504

ELOC
Elongin-C

3

0

Small-scale

0.613

High

716484

GFRP
GTP cyclohydrolase 1 feedback regulatory protein

2

0

High-throughput

0.602

High

1119535

RBX2
RING-box protein 2

2

1

Small-scale

0.595

High

371988

MYC
Myc proto-oncogene protein

2

0

Small-scale

0.585

High

947881

T2R41
Taste receptor type 2 member 41

2

0

High-throughput

0.585

High

1104575

IKZF1
DNA-binding protein Ikaros

2

2

Small-scale

0.584

High

1119538

IKZF3
Zinc finger protein Aiolos

2

2

Small-scale

0.584

High

1119524

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

2

0

High-throughput

0.559

High

1119505

ELOB
Elongin-B

2

0

Small-scale

0.547

High

765495

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.536

High

1091065

FOXF2
Forkhead box protein F2

1

1

High-throughput

0.536

High

1119519

HS105
Heat shock protein 105 kDa

1

2

High-throughput

0.536

High

1119529

ABC3G
DNA dC->dU-editing enzyme APOBEC-3G

1

0

Small-scale

0.517

High

66930

AQ12B
Putative aquaporin-12B

1

0

High-throughput

0.513

High

291649

XRP2
Protein XRP2

1

0

High-throughput

0.513

High

1119501

LRC32
Transforming growth factor beta activator LRRC32

1

0

High-throughput

0.513

High

1119507

DOXA2
Dual oxidase maturation factor 2

1

0

High-throughput

0.513

High

1119541

NIP7
60S ribosome subunit biogenesis protein NIP7 homolog

1

0

High-throughput

0.513

High

930883

HSP72
Heat shock-related 70 kDa protein 2

1

0

High-throughput

0.493

High

1119531

INT13
Integrator complex subunit 13

1

0

High-throughput

0.493

High

343945

HS74L
Heat shock 70 kDa protein 4L

1

2

High-throughput

0.489

High

761675

HSP74
Heat shock 70 kDa protein 4

1

2

High-throughput

0.489

High

1119512

SESQ1
Sesquipedalian-1

1

2

High-throughput

0.489

High

1119530

COPRS
Coordinator of PRMT5 and differentiation stimulator

1

0

Small-scale

0.480

High

335122

ARI2
E3 ubiquitin-protein ligase ARIH2

1

1

High-throughput

0.479

High

340885

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

1

High-throughput

0.479

High

422087

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.479

High

429866

JUN
Transcription factor Jun

1

1

High-throughput

0.479

High

606746

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

714107

PML
Protein PML

1

1

High-throughput

0.479

High

886841

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.479

High

983798

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

High-throughput

0.479

High

1091098

FOXC1
Forkhead box protein C1

1

1

High-throughput

0.479

High

1099871

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

1119537

IKZF2
Zinc finger protein Helios

1

2

High-throughput

0.479

High

1119543

ARI1
E3 ubiquitin-protein ligase ARIH1

1

1

High-throughput

0.479

High

124336

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.458

High

130745

TAF4
Transcription initiation factor TFIID subunit 4

1

0

High-throughput

0.458

High

188273

HDAC3
Histone deacetylase 3

1

0

High-throughput

0.458

High

227553

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.458

High

259928

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

270245

MTG16
Protein CBFA2T3

1

0

Small-scale

0.458

High

278342

NCOR1
Nuclear receptor corepressor 1

1

0

High-throughput

0.458

High

347695

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

402925

ANXA1
Annexin A1

1

0

High-throughput

0.458

High

581658

MYOD1
Myoblast determination protein 1

1

0

Small-scale

0.458

High

651321

CBL
E3 ubiquitin-protein ligase CBL

1

0

High-throughput

0.458

High

651659

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

0

High-throughput

0.458

High

764741

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

783068

TCF7
Transcription factor 7

1

0

High-throughput

0.458

High

842366

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.458

High

851763

NKX21
Homeobox protein Nkx-2.1

1

0

High-throughput

0.458

High

854849

RECQ1
ATP-dependent DNA helicase Q1

1

0

High-throughput

0.458

High

890829

TSC2
Tuberin

1

0

High-throughput

0.458

High

894739

EMD
Emerin

1

0

High-throughput

0.458

High

910507

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

High-throughput

0.458

High

926466

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

1040287

DYST
Dystonin

1

0

High-throughput

0.458

High

1040798

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

High-throughput

0.458

High

1041518

KMT2A
Histone-lysine N-methyltransferase 2A

1

0

Small-scale

0.458

High

1043673

CEBPZ
CCAAT/enhancer-binding protein zeta

1

0

High-throughput

0.458

High

1047970

TLE3
Transducin-like enhancer protein 3

1

0

High-throughput

0.458

High

1087731

NFIA
Nuclear factor 1 A-type

1

0

High-throughput

0.458

High

1119503

HLTF
Helicase-like transcription factor

1

0

High-throughput

0.458

High

1119506

NEDD8
Ubiquitin-like protein NEDD8

1

0

High-throughput

0.458

High

1119509

S4A10
Sodium-driven chloride bicarbonate exchanger

1

0

High-throughput

0.458

High

1119515

DCA11
DDB1- and CUL4-associated factor 11

1

0

High-throughput

0.458

High

1119516

PDC6I
Programmed cell death 6-interacting protein

1

0

High-throughput

0.458

High

1119521

RBM14
RNA-binding protein 14

1

0

High-throughput

0.458

High

1119523

HTF4
Transcription factor 12

1

0

High-throughput

0.458

High

1119525

BC11B
B-cell lymphoma/leukemia 11B

1

0

High-throughput

0.458

High

1119527

DHX36
ATP-dependent DNA/RNA helicase DHX36

1

0

High-throughput

0.458

High

1119539

AKP8L
A-kinase anchor protein 8-like

1

0

High-throughput

0.458

High

1119542

ZBTB1
Zinc finger and BTB domain-containing protein 1

1

0

High-throughput

0.458

High

1119528

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

1119508

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1119517

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

0

High-throughput

0.426

High

1119522

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

679339

DNJB2
DnaJ homolog subfamily B member 2

1

1

High-throughput

0.407

High

1119514

DNJB8
DnaJ homolog subfamily B member 8

1

1

High-throughput

0.407

High

787643

SPB5
Serpin B5

2

0

High-throughput

0.318

High

1119513

AR6P6
ADP-ribosylation factor-like protein 6-interacting protein 6

2

0

High-throughput

0.318

High

1119526

S2532
Solute carrier family 25 member 32

2

0

High-throughput

0.318

High

1119533

HPBP1
Hsp70-binding protein 1

2

0

High-throughput

0.318

High

956287

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.292

High

421158

SCG1
Secretogranin-1

1

0

High-throughput

0.282

High

477165

ACM5
Muscarinic acetylcholine receptor M5

1

0

High-throughput

0.282

High

289318

FCN3
Ficolin-3

1

0

High-throughput

0.279

Low

1119510

FBW12
F-box/WD repeat-containing protein 12

1

0

High-throughput

0.279

Low

1119511

LHPL4
LHFPL tetraspan subfamily member 4 protein

1

0

High-throughput

0.279

Low

1119518

ASM3B
Acid sphingomyelinase-like phosphodiesterase 3b

1

0

High-throughput

0.279

Low

1119532

RBM28
RNA-binding protein 28

1

0

High-throughput

0.279

Low

1119536

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

High-throughput

0.279

Low

175039

SC16A
Protein transport protein Sec16A

1

0

High-throughput

0.249

Low

258377

GAS7
Growth arrest-specific protein 7

1

0

High-throughput

0.249

Low

536339

MTAP2
Microtubule-associated protein 2

1

0

High-throughput

0.249

Low

629853

BTF3
Transcription factor BTF3

1

0

High-throughput

0.249

Low

639130

SYT1
Synaptotagmin-1

1

0

High-throughput

0.249

Low

717473

PDIA3
Protein disulfide-isomerase A3

1

0

High-throughput

0.249

Low

996946

TBA4A
Tubulin alpha-4A chain

1

0

High-throughput

0.249

Low

1036623

CO7A1
Collagen alpha-1(VII) chain

1

0

High-throughput

0.249

Low

1100764

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.249

Low

1119502

SPRL1
SPARC-like protein 1

1

0

High-throughput

0.249

Low

1119540

UBP18
Ubl carboxyl-terminal hydrolase 18

1

0

Small-scale

0.249

Low

1119544

YTHD2
YTH domain-containing family protein 2

1

0

High-throughput

0.249

Low

440551

FYN
Tyrosine-protein kinase Fyn

1

0

High-throughput

0.232

Low

922383

CRBA4
Beta-crystallin A4

1

0

High-throughput

0.232

Low

1015016

ARF5
ADP-ribosylation factor 5

1

0

High-throughput

0.232

Low

1119534

WRP73
WD repeat-containing protein WRAP73

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025