Protein: RUNX3
Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit)

Gene: RUNX3
Organism: Homo sapiens
Interactions: 65
UniProt ID: Q13761

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1117047

PEBB
Core-binding factor subunit beta

6

8

Small-scale

0.942

High

1117046

RUNX2
Runt-related transcription factor 2

1

2

High-throughput

0.691

High

1014505

SMAD3
Mothers against decapentaplegic homolog 3

3

16

Small-scale

0.640

High

1067305

EP300
Histone acetyltransferase p300

2

9

Small-scale

0.611

High

1117078

HDAC5
Histone deacetylase 5

2

16

Small-scale

0.594

High

1047812

TLE1
Transducin-like enhancer protein 1

1

10

Small-scale

0.582

High

764735

CTNB1
Catenin beta-1

1

2

Small-scale

0.565

High

1117074

TF7L2
Transcription factor 7-like 2

1

7

Small-scale

0.565

High

371976

MYC
Myc proto-oncogene protein

1

3

Small-scale

0.561

High

406156

MYCN
N-myc proto-oncogene protein

1

3

Small-scale

0.561

High

413799

P53
Cellular tumor antigen p53

1

2

Small-scale

0.561

High

857451

NOTC1
Neurogenic locus notch homolog protein 1

1

1

Small-scale

0.561

High

1117055

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

2

Small-scale

0.561

High

557288

SRC
Proto-oncogene tyrosine-protein kinase Src

1

4

Small-scale

0.554

High

1117072

SP110
Sp110 nuclear body protein

1

1

High-throughput

0.541

High

466666

GLI1
Zinc finger protein GLI1

1

0

Small-scale

0.537

High

674160

BRD2
Bromodomain-containing protein 2

1

9

Small-scale

0.536

High

940955

HDAC4
Histone deacetylase 4

1

16

Small-scale

0.536

High

1117053

FBW12
F-box/WD repeat-containing protein 12

1

2

High-throughput

0.536

High

1117065

PHB2
Prohibitin-2

1

1

High-throughput

0.515

High

862113

YAP1
Transcriptional coactivator YAP1

1

19

Small-scale

0.501

High

329143

RCBT2
RCC1 and BTB domain-containing protein 2

1

0

High-throughput

0.493

High

664735

CCND1
G1/S-specific cyclin-D1

1

1

Small-scale

0.484

High

216432

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

2

Small-scale

0.479

High

259920

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

440068

LCK
Tyrosine-protein kinase Lck

1

4

Small-scale

0.479

High

440545

FYN
Tyrosine-protein kinase Fyn

1

4

Small-scale

0.479

High

606740

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

629847

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

714103

PML
Protein PML

1

6

Small-scale

0.479

High

783067

TCF7
Transcription factor 7

1

7

Small-scale

0.479

High

854844

RECQ1
ATP-dependent DNA helicase Q1

1

5

High-throughput

0.479

High

891529

GSK3B
Glycogen synthase kinase-3 beta

1

2

Small-scale

0.479

High

1104572

IKZF1
DNA-binding protein Ikaros

1

3

Small-scale

0.479

High

1109257

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.479

High

1109705

HDAC1
Histone deacetylase 1

1

11

Small-scale

0.479

High

1117048

SMAD2
Mothers against decapentaplegic homolog 2

1

16

Small-scale

0.479

High

1117049

SMAD1
Mothers against decapentaplegic homolog 1

1

16

Small-scale

0.479

High

1117050

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

Small-scale

0.479

High

1117051

HIF1A
Hypoxia-inducible factor 1-alpha

1

3

Small-scale

0.479

High

1117052

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

1

2

Small-scale

0.479

High

1117054

MEX3B
RNA-binding protein MEX3B

1

1

Small-scale

0.479

High

1117056

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

1

Small-scale

0.479

High

1117061

FBXW7
F-box/WD repeat-containing protein 7

1

1

Small-scale

0.479

High

1117062

EGLN2
Prolyl hydroxylase EGLN2

1

1

Small-scale

0.479

High

1117064

CIC
Protein capicua homolog

1

7

High-throughput

0.479

High

1117067

SMAD5
Mothers against decapentaplegic homolog 5

1

16

Small-scale

0.479

High

1117068

FACD2
Fanconi anemia group D2 protein

1

1

Small-scale

0.479

High

1117069

EGLN1
Egl nine homolog 1

1

1

Small-scale

0.479

High

1117070

NANOG
Homeobox protein NANOG

1

3

High-throughput

0.479

High

1117071

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

11

Small-scale

0.479

High

1117073

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

11

Small-scale

0.479

High

1117076

IKZF3
Zinc finger protein Aiolos

1

3

Small-scale

0.479

High

1028190

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

1054705

SUH
Recombining binding protein suppressor of hairless

1

0

Small-scale

0.458

High

1094497

ZBT17
Zinc finger and BTB domain-containing protein 17

1

0

Small-scale

0.458

High

1117057

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

0

Small-scale

0.458

High

1117060

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1117075

FANCI
Fanconi anemia group I protein

1

0

Small-scale

0.458

High

1117077

SUFU
Suppressor of fused homolog

1

0

Small-scale

0.458

High

1117058

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.445

High

850819

KI2L3
Killer cell immunoglobulin-like receptor 2DL3

1

3

Small-scale

0.437

High

1117059

KI3L3
Killer cell immunoglobulin-like receptor 3DL3

1

3

Small-scale

0.437

High

1117066

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

3

Small-scale

0.437

High

1117063

GUCD1
Protein GUCD1

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025