HitPredict

Interactor 1: PLCB3 (Q01970)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3)
Gene: PLCB3

Interactor 2: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

Property	Details
Experiments	10748023, 33961781, unassigned3799
Identification Methods	pull down, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045296 - cadherin binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1234 Hs			1 337
+	Hs
		162821 PLCB3_HUMAN (1-1234): 0: 1121: 100.00		NHRF1_HUMAN (2-337): 3.07e-71: 227: 48.87
+	Hs
		1026937 PLCB2_HUMAN (13-1230): 0: 970: 43.18		NHRF2_HUMAN (1-337): 6.41e-81: 251: 100.00
+	Hs
		162861 PLCB1_HUMAN (1-1202): 0: 961: 52.77		NHRF1_HUMAN (2-337): 3.07e-71: 227: 48.87
+	Hs
		1034121 PLCB3_HUMAN (1-1234): 0: 1121: 100.00		SNX27_HUMAN (149-228): 1.9e-09: 60.8: 38.71
+	Hs
		1034135 PLCB3_HUMAN (1-1234): 0: 1121: 100.00		LIN7C_HUMAN (9-87): 8.54e-09: 56.6: 40.74