Protein: PLCB3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3)

Gene: PLCB3
Organism: Homo sapiens
Interactions: 70
UniProt ID: Q01970

Gene Ontology (top 5):
GO:0003073 - regulation of systemic arterial blood pressure
GO:0004435 - phosphatidylinositol-4,5-bisphosphate phospholipase C activity
GO:0004629 - phospholipase C activity
GO:0005509 - calcium ion binding
GO:0005516 - calmodulin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1034096

STRN3
Striatin-3

1

1

High-throughput

0.691

High

1034098

SNTA1
Alpha-1-syntrophin

1

1

Small-scale

0.691

High

1034101

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

3

5

Small-scale

0.674

High

1034114

NEDD1
Protein NEDD1

1

0

High-throughput

0.656

High

374535

RASH
GTPase HRas

1

19

High-throughput

0.618

High

375423

RASK
GTPase KRas

1

20

High-throughput

0.618

High

580997

RAC2
Ras-related C3 botulinum toxin substrate 2

1

13

High-throughput

0.618

High

988293

RAC1
Ras-related C3 botulinum toxin substrate 1

1

14

High-throughput

0.618

High

1034104

DCAF6
DDB1- and CUL4-associated factor 6

1

3

High-throughput

0.618

High

1034130

RHOF
Rho-related GTP-binding protein RhoF

1

19

High-throughput

0.618

High

162821

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

2

4

Small-scale

0.611

High

139128

KRIT1
Krev interaction trapped protein 1

1

3

Small-scale

0.561

High

1034131

LPAR2
Lysophosphatidic acid receptor 2

1

0

Small-scale

0.537

High

250560

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

2

High-throughput

0.536

High

322656

KDM4B
Lysine-specific demethylase 4B

1

1

High-throughput

0.536

High

391226

FRIL
Ferritin light chain

1

1

High-throughput

0.536

High

531045

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

3

High-throughput

0.536

High

603640

JUNB
Transcription factor JunB

1

1

High-throughput

0.536

High

922568

AP2S1
AP-2 complex subunit sigma

1

1

High-throughput

0.536

High

1034102

ZN174
Zinc finger protein 174

1

1

High-throughput

0.536

High

1034111

P66A
Transcriptional repressor p66-alpha

1

1

High-throughput

0.536

High

1034119

RNF31
E3 ubiquitin-protein ligase RNF31

1

7

High-throughput

0.536

High

1034135

LIN7C
Protein lin-7 homolog C

1

2

High-throughput

0.536

High

1034138

CTNA3
Catenin alpha-3

1

2

High-throughput

0.536

High

1034142

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

4

High-throughput

0.536

High

1034115

PARD3
Partitioning defective 3 homolog

1

1

Small-scale

0.515

High

665569

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

0

High-throughput

0.513

High

665967

IBP5
Insulin-like growth factor-binding protein 5

1

0

High-throughput

0.513

High

1034106

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

1

0

High-throughput

0.513

High

1034113

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.513

High

1034116

APC16
Anaphase-promoting complex subunit 16

1

0

High-throughput

0.513

High

1034117

RM38
Large ribosomal subunit protein mL38

1

0

High-throughput

0.513

High

1034124

SORT
Sortilin

1

0

High-throughput

0.513

High

1034125

HAUS7
HAUS augmin-like complex subunit 7

1

0

High-throughput

0.513

High

1034126

RAMAC
RNA guanine-N7 methyltransferase activating subunit

1

0

High-throughput

0.513

High

1034127

MND1
Meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.513

High

1034129

CB39L
Calcium-binding protein 39-like

1

0

High-throughput

0.513

High

1034133

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.513

High

1034134

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

1

0

High-throughput

0.513

High

1034136

FGOP2
FGFR1 oncogene partner 2

1

0

High-throughput

0.513

High

1034137

TMM51
Transmembrane protein 51

1

0

High-throughput

0.513

High

1034140

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

0

High-throughput

0.513

High

1034123

TRPM7
Transient receptor potential cation channel subfamily M member 7

1

4

Small-scale

0.501

High

1034132

PAR6A
Partitioning defective 6 homolog alpha

1

0

Small-scale

0.493

High

635475

MAG
Myelin-associated glycoprotein

1

6

High-throughput

0.489

High

1034110

MILR1
Allergin-1

1

8

High-throughput

0.489

High

540408

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.479

High

582752

EZRI
Ezrin

1

1

Small-scale

0.479

High

695247

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

1034095

TF65
Transcription factor p65

1

2

High-throughput

0.479

High

1034097

SKP2
S-phase kinase-associated protein 2

1

5

Small-scale

0.479

High

1034105

RN123
E3 ubiquitin-protein ligase RNF123

1

5

High-throughput

0.479

High

1034108

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

1034121

SNX27
Sorting nexin-27

1

12

High-throughput

0.479

High

1034128

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

1

1

High-throughput

0.479

High

418073

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

556022

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

1034099

CUL7
Cullin-7

1

0

High-throughput

0.458

High

1034100

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1034103

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.458

High

1034107

TT23L
Tetratricopeptide repeat protein 23-like

1

0

High-throughput

0.458

High

1034112

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.458

High

1034122

GCNA
Germ cell nuclear acidic protein

1

0

High-throughput

0.458

High

1034139

ODF2L
Protein BCAP

1

0

High-throughput

0.458

High

767989

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

1034109

NRK
Nik-related protein kinase

1

4

High-throughput

0.437

High

254976

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.407

High

1034118

KBP
KIF-binding protein

1

0

High-throughput

0.279

Low

1034120

CH076
Uncharacterized protein C8orf76

1

0

High-throughput

0.279

Low

1034141

RT18C
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025