HitPredict

Interactor 1: ASCL1 (Q02067)
Achaete-scute homolog 1 (ASH-1) (mASH-1) (mASH1)
Gene: ASCL1

Interactor 2: HTF4 (Q61286)
Transcription factor 12 (TCF-12) (Class A helix-loop-helix transcription factor ME1) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4)
Gene: Tcf12

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	8948587
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0005634 - nucleus GO:0007399 - nervous system development GO:0043425 - bHLH transcription factor binding GO:0045666 - positive regulation of neuron differentiation GO:0070888 - E-box binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 231 Mm			1 706
+	Mm
		1222209 HAND2_MOUSE (47-230): 3.96e-32: 118: 19.57		HTF4_MOUSE (1-706): 0: 925: 100.00
+	Hs
		896697 ASCL1_HUMAN (1-231): 1.84e-36: 130: 88.14		HTF4_HUMAN (1-706): 0: 891: 92.21
+	Hs
		1110781 NDF1_HUMAN (8-222): 5.6e-33: 123: 18.64		HTF4_HUMAN (1-706): 0: 891: 92.21
+	Hs
		1369574 ATOH1_HUMAN (18-182): 3.14e-31: 119: 25.14		HTF4_HUMAN (1-706): 0: 891: 92.21
+	Hs
		658507 MYF6_HUMAN (55-213): 4.89e-32: 118: 23.78		HTF4_HUMAN (1-706): 0: 891: 92.21
+	Mm
		1221379 HAND2_MOUSE (47-230): 3.96e-32: 118: 19.57		ITF2_MOUSE (2-706): 0: 781: 59.55
+	Hs
		587028 ASCL1_HUMAN (1-231): 1.84e-36: 130: 88.14		ITF2_HUMAN (2-706): 0: 754: 59.05
+	Hs
		587075 NDF1_HUMAN (8-222): 5.6e-33: 123: 18.64		ITF2_HUMAN (2-706): 0: 754: 59.05
+	Hs
		587121 PTF1A_HUMAN (59-230): 1.86e-31: 119: 20.46		ITF2_HUMAN (2-706): 0: 754: 59.05
+	Hs
		587004 MYF6_HUMAN (55-213): 4.89e-32: 118: 23.78		ITF2_HUMAN (2-706): 0: 754: 59.05
+	Hs
		587432 ASCL1_HUMAN (1-231): 1.84e-36: 130: 88.14		TFE2_HUMAN (2-706): 0: 733: 46.69
+	Hs
		587467 NDF1_HUMAN (8-222): 5.6e-33: 123: 18.64		TFE2_HUMAN (2-706): 0: 733: 46.69
+	Hs
		587492 PTF1A_HUMAN (59-230): 1.86e-31: 119: 20.46		TFE2_HUMAN (2-706): 0: 733: 46.69
+	Hs
		587512 ATOH1_HUMAN (18-182): 3.14e-31: 119: 25.14		TFE2_HUMAN (2-706): 0: 733: 46.69
+	Hs
		587418 MYF6_HUMAN (55-213): 4.89e-32: 118: 23.78		TFE2_HUMAN (2-706): 0: 733: 46.69
+	Mm
		586103 ASCL1_MOUSE (1-231): 1.41e-38: 135: 100.00		TFE2_MOUSE (1-706): 0: 706: 46.89
+	Mm
		586108 NDF1_MOUSE (8-222): 3.9e-31: 118: 18.64		TFE2_MOUSE (1-706): 0: 706: 46.89
+	Mm
		586112 HAND2_MOUSE (47-230): 3.96e-32: 118: 19.57		TFE2_MOUSE (1-706): 0: 706: 46.89
+	Mm
		1221922 NDF1_MOUSE (8-222): 3.9e-31: 118: 18.64		Q91XK1_MOUSE (193-706): 0: 579: 61.03
+	Ce
		112497 HLH6_CAEEL (15-177): 8.18e-34: 123: 26.47		HLH2_CAEEL (500-674): 1.23e-30: 126: 32.96