HitPredict

Interactor 1: NRG1 (Q02297)
Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]
Gene: NRG1

Interactor 2: GOLI (Q86XS8)
E3 ubiquitin-protein ligase RNF130 (EC 2.3.2.27) (Goliath homolog) (H-Goliath) (RING finger protein 130) (RING-type E3 ubiquitin transferase RNF130)
Gene: RNF130

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26186194
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008270 - zinc ion binding GO:0016020 - membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 640 Hs			1 419
+	Hs
		522704 PTPRF_HUMAN (3-576): 1.6e-19: 95.9: 12.20		RN128_HUMAN (1-384): 1.52e-92: 287: 36.90
+	Hs
		522699 PTPRF_HUMAN (3-576): 1.6e-19: 95.9: 12.20		RN149_HUMAN (25-343): 1.17e-82: 260: 42.15
+	Hs
		522708 PTPRF_HUMAN (3-576): 1.6e-19: 95.9: 12.20		RN133_HUMAN (4-373): 6.87e-82: 258: 26.42
+	Hs
		1217410 OBSCN_HUMAN (39-635): 6e-11: 68.2: 12.52		RNF43_HUMAN (19-378): 7.39e-60: 209: 17.87
+	Hs
		1229011 TITIN_HUMAN (19-217): 1.21e-10: 67.4: 11.33		RNF43_HUMAN (19-378): 7.39e-60: 209: 17.87
+	Hs
		1361915 TITIN_HUMAN (19-217): 1.21e-10: 67.4: 11.33		RN167_HUMAN (46-366): 1.13e-59: 199: 21.71
+	Mm
		1243958 MYLK_MOUSE (14-129): 2.07e-20: 98.6: 20.51		RNF6_MOUSE (134-310): 5.24e-34: 136: 24.29