Protein: RN128
E3 ubiquitin-protein ligase RNF128 (EC 2.3.2.27) (Gene related to anergy in lymphocytes protein) (GRAIL) (RING finger protein 128) (RING-type E3 ubiquitin transferase RNF128)

Gene: RN128, RNF128
Organism: Homo sapiens
Interactions: 69
UniProt ID: Q8TEB7

Gene Ontology (top 5):
GO:0001818 - negative regulation of cytokine production
GO:0005737 - cytoplasm
GO:0005770 - late endosome
GO:0005783 - endoplasmic reticulum
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

906718

UB2D1
Ubiquitin-conjugating enzyme E2 D1

3

20

Small-scale

0.840

High

1352293

RN128
E3 ubiquitin-protein ligase RNF128

3

15

Small-scale

0.840

High

1352312

UBQL2
Ubiquilin-2

2

13

High-throughput

0.783

High

993666

UBC9
SUMO-conjugating enzyme UBC9

1

20

High-throughput

0.698

High

1180936

HFE
Hereditary hemochromatosis protein

1

8

High-throughput

0.691

High

1334478

RN149
E3 ubiquitin-protein ligase RNF149

1

16

High-throughput

0.691

High

909357

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

Small-scale

0.647

High

957799

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.647

High

970824

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

Small-scale

0.647

High

1347427

CEP76
Centrosomal protein of 76 kDa

3

0

High-throughput

0.646

High

1352311

TBK1
Serine/threonine-protein kinase TBK1

2

2

Small-scale

0.634

High

1352309

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

20

High-throughput

0.625

High

242383

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.618

High

390692

TFR1
Transferrin receptor protein 1

1

2

High-throughput

0.618

High

409461

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

4

High-throughput

0.618

High

957145

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

Small-scale

0.618

High

414279

P53
Cellular tumor antigen p53

2

5

Small-scale

0.614

High

1139022

SNX17
Sorting nexin-17

2

0

High-throughput

0.580

High

1352295

APBP2
Amyloid protein-binding protein 2

1

1

High-throughput

0.573

High

1352298

OTUB1
Ubiquitin thioesterase OTUB1

1

0

Small-scale

0.549

High

715441

CD40L
CD40 ligand

1

0

Small-scale

0.537

High

1352302

TMM59
Transmembrane protein 59

1

2

High-throughput

0.536

High

363605

EGFR
Epidermal growth factor receptor

1

7

Small-scale

0.501

High

124417

HAX1
HCLS1-associated protein X-1

1

2

High-throughput

0.479

High

132179

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

High-throughput

0.479

High

273561

DJC13
DnaJ homolog subfamily C member 13

1

10

High-throughput

0.479

High

698933

CALX
Calnexin

1

6

High-throughput

0.479

High

722732

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

2

High-throughput

0.479

High

764904

CTNB1
Catenin beta-1

1

1

Small-scale

0.479

High

828232

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

6

Small-scale

0.479

High

847618

SSRA
Translocon-associated protein subunit alpha

1

2

High-throughput

0.479

High

1055334

APLP2
Amyloid beta precursor like protein 2

1

5

High-throughput

0.479

High

1089988

LMAN2
Vesicular integral-membrane protein VIP36

1

6

High-throughput

0.479

High

1097710

STK3
Serine/threonine-protein kinase 3

1

1

Small-scale

0.479

High

1101759

PTK7
Inactive tyrosine-protein kinase 7

1

9

High-throughput

0.479

High

1116766

AAMP
Angio-associated migratory cell protein

1

3

High-throughput

0.479

High

1141818

EEA1
Early endosome antigen 1

1

5

High-throughput

0.479

High

1214884

WLS
Protein wntless homolog

1

1

High-throughput

0.479

High

1239524

ZNT6
Zinc transporter 6

1

14

High-throughput

0.479

High

1250821

RFIP1
Rab11 family-interacting protein 1

1

6

High-throughput

0.479

High

1346737

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

14

High-throughput

0.479

High

1352296

GSLG1
Golgi apparatus protein 1

1

2

High-throughput

0.479

High

1352297

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

4

High-throughput

0.479

High

1352299

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

6

High-throughput

0.479

High

1352300

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

6

High-throughput

0.479

High

1352301

SDF2
Stromal cell-derived factor 2

1

6

High-throughput

0.479

High

1352303

ZDHC5
Palmitoyltransferase ZDHHC5

1

7

High-throughput

0.479

High

1352304

LMA2L
VIP36-like protein

1

6

High-throughput

0.479

High

1352306

SDF2L
Stromal cell-derived factor 2-like protein 1

1

6

High-throughput

0.479

High

1352307

TM9S3
Transmembrane 9 superfamily member 3

1

3

High-throughput

0.479

High

1352308

WDR6
tRNA

1

10

High-throughput

0.479

High

1352310

DJB11
DnaJ homolog subfamily B member 11

1

8

High-throughput

0.479

High

1352314

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.479

High

1352315

FBW1A
F-box/WD repeat-containing protein 1A

1

5

Small-scale

0.479

High

1352316

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

4

High-throughput

0.479

High

619226

EPOR
Erythropoietin receptor

1

7

Small-scale

0.457

High

1142511

PDCD1
Programmed cell death protein 1

1

3

Small-scale

0.457

High

388438

B3AT
Band 3 anion transport protein

1

6

High-throughput

0.445

High

943528

G6PT2
Glucose-6-phosphate exchanger SLC37A1

1

9

High-throughput

0.445

High

163332

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

3

High-throughput

0.437

High

522704

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

8

High-throughput

0.437

High

912699

CTR2
Cationic amino acid transporter 2

1

9

High-throughput

0.437

High

1143760

PON2
Serum paraoxonase/arylesterase 2

1

4

High-throughput

0.437

High

1293267

LSR
Lipolysis-stimulated lipoprotein receptor

1

1

High-throughput

0.437

High

1352305

TMX1
Thioredoxin-related transmembrane protein 1

1

16

High-throughput

0.437

High

1352313

S39AA
Zinc transporter ZIP10

1

5

High-throughput

0.437

High

1352294

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

9

High-throughput

0.407

High

1029621

CD83
CD83 antigen

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025