Protein: RN167
E3 ubiquitin-protein ligase RNF167 (EC 2.3.2.27) (RING finger protein 167)

Gene: RN167, RNF167
Organism: Homo sapiens
Interactions: 70
UniProt ID: Q9H6Y7

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm
GO:0005764 - lysosome
GO:0005765 - lysosomal membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

909389

UB2E1
Ubiquitin-conjugating enzyme E2 E1

5

20

Small-scale

0.928

High

982322

UB2D2
Ubiquitin-conjugating enzyme E2 D2

5

20

Small-scale

0.924

High

906783

UB2D1
Ubiquitin-conjugating enzyme E2 D1

4

20

Small-scale

0.896

High

1435272

RN167
E3 ubiquitin-protein ligase RNF167

4

14

Small-scale

0.885

High

1383934

UBE2W
Ubiquitin-conjugating enzyme E2 W

3

20

Small-scale

0.868

High

1381201

UB2E3
Ubiquitin-conjugating enzyme E2 E3

3

20

Small-scale

0.867

High

957671

UBE2K
Ubiquitin-conjugating enzyme E2 K

3

20

Small-scale

0.849

High

220516

RNF13
E3 ubiquitin-protein ligase RNF13

2

15

High-throughput

0.811

High

627569

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

2

8

High-throughput

0.811

High

957200

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.800

High

957843

UBE2N
Ubiquitin-conjugating enzyme E2 N

2

20

Small-scale

0.800

High

1435277

UB2D4
Ubiquitin-conjugating enzyme E2 D4

2

20

Small-scale

0.800

High

438911

CD1A
T-cell surface glycoprotein CD1a

1

9

High-throughput

0.691

High

1180963

HFE
Hereditary hemochromatosis protein

1

7

High-throughput

0.691

High

1435279

SRPRB
Signal recognition particle receptor subunit beta

3

16

High-throughput

0.667

High

144194

UBE2C
Ubiquitin-conjugating enzyme E2 C

1

20

Small-scale

0.647

High

883331

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

20

Small-scale

0.647

High

884398

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

20

Small-scale

0.647

High

952472

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

20

Small-scale

0.647

High

990989

UBE2B
Ubiquitin-conjugating enzyme E2 B

1

20

Small-scale

0.647

High

1435273

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

20

Small-scale

0.647

High

609805

LEG3
Galectin-3

2

5

High-throughput

0.628

High

1286906

TM11B
Transmembrane protease serine 11B

2

2

High-throughput

0.628

High

957517

UBC12
NEDD8-conjugating enzyme Ubc12

1

20

High-throughput

0.618

High

1143796

PON2
Serum paraoxonase/arylesterase 2

2

4

High-throughput

0.611

High

219369

B4GA1
Beta-1,4-glucuronyltransferase 1

2

1

High-throughput

0.574

High

1364934

AP3S1
AP-3 complex subunit sigma-1

2

4

High-throughput

0.574

High

1384629

S67A1
Solute carrier family 67 member A1

1

4

Small-scale

0.573

High

1429843

TOLIP
Toll-interacting protein

1

2

Small-scale

0.561

High

838508

GRIA2
Glutamate receptor 2

1

0

Small-scale

0.554

High

945683

SESN2
Sestrin-2

1

0

Small-scale

0.554

High

556958

MYH7
Myosin-7

1

6

High-throughput

0.541

High

635098

CAN3
Calpain-3

1

1

High-throughput

0.541

High

991432

SUMO1
Small ubiquitin-related modifier 1

1

1

High-throughput

0.541

High

996537

ACTS
Actin, alpha skeletal muscle

1

2

High-throughput

0.541

High

1361915

TITIN
Titin

1

3

High-throughput

0.541

High

1435278

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

High-throughput

0.541

High

540677

LAMP1
Lysosome-associated membrane glycoprotein 1

1

1

High-throughput

0.536

High

688629

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

8

High-throughput

0.536

High

851220

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

6

High-throughput

0.536

High

1059328

NKG2E
NKG2-E type II integral membrane protein

1

8

High-throughput

0.536

High

1332621

I17RC
Interleukin-17 receptor C

1

1

High-throughput

0.536

High

75537

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

363864

EGFR
Epidermal growth factor receptor

1

7

Small-scale

0.501

High

636765

PTN
Pleiotrophin

1

1

Small-scale

0.501

High

901576

RAB7A
Ras-related protein Rab-7a

1

14

Small-scale

0.501

High

1142530

PDCD1
Programmed cell death protein 1

1

2

Small-scale

0.501

High

1278998

TAFA5
Chemokine-like protein TAFA-5

1

1

Small-scale

0.501

High

1325173

TAFA2
Chemokine-like protein TAFA-2

1

1

Small-scale

0.501

High

174094

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

6

High-throughput

0.494

High

848566

MAGA8
Melanoma-associated antigen 8

1

2

High-throughput

0.489

High

214035

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

2

Small-scale

0.479

High

165778

PAHX
Phytanoyl-CoA dioxygenase, peroxisomal

1

0

High-throughput

0.458

High

1356207

CAST1
Cytosolic arginine sensor for mTORC1 subunit 1

1

0

Small-scale

0.458

High

640620

MK
Midkine

1

1

Small-scale

0.457

High

880813

NRAM1
Natural resistance-associated macrophage protein 1

1

1

High-throughput

0.445

High

1139574

S39AE
Metal cation symporter ZIP14

1

5

High-throughput

0.445

High

1236318

MFSD5
Molybdate-anion transporter

1

1

High-throughput

0.445

High

1238899

MFS12
Major facilitator superfamily domain-containing protein 12

1

1

High-throughput

0.445

High

1251189

ZNT10
Calcium/manganese antiporter SLC30A10

1

8

High-throughput

0.445

High

1288164

SL9B2
Sodium/hydrogen exchanger 9B2

1

4

High-throughput

0.445

High

1417637

S46A2
Solute carrier family 46 member 2

1

4

High-throughput

0.445

High

1435274

SL2A8
Solute carrier family 2, facilitated glucose transporter member 8

1

1

High-throughput

0.445

High

190485

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.426

High

1334282

S38A9
Neutral amino acid transporter 9

1

0

High-throughput

0.426

High

943549

G6PT2
Glucose-6-phosphate exchanger SLC37A1

1

6

High-throughput

0.407

High

1435276

A4GCT
Alpha-1,4-N-acetylglucosaminyltransferase

3

0

High-throughput

0.347

High

1435275

TAP26
Thyroid transcription factor 1-associated protein 26

1

0

High-throughput

0.269

Low

1389591

SAAL1
Protein SAAL1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025