HitPredict

Interactor 1: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Interactor 2: MLP3A (Q9H492)
Microtubule-associated proteins 1A/1B light chain 3A (Autophagy-related protein LC3 A) (Autophagy-related ubiquitin-like modifier LC3 A) (MAP1 light chain 3-like protein 1) (MAP1A/MAP1B light chain 3 A) (MAP1A/MAP1B LC3 A) (Microtubule-associated protein 1 light chain 3 alpha)
Gene: MAP1LC3A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 0.60 0.771

The method score is based on:

Property Details
Experiments 19021777, 25450619, 25686248, 25921531, 25984893, 28380357, 32123815, 31286822, 34645818, 34758851, 35654983, 36036324, 36223738, 36952345, 19250911, 21045561, 23459205, 22963397, 23989536, 23640897 and 33 others

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Identification Methods x-ray crystallography, pull down, affinity chromatography technology, two hybrid, unspecified method, biochemical, anti tag coimmunoprecipitation, two hybrid array, two hybrid prey pooling approach, phage display and 2 others

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Interaction Type association, direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000422 - autophagy of mitochondrion
GO:0005770 - late endosome
GO:0005776 - autophagosome
GO:0005829 - cytosol
GO:0016236 - macroautophagy
and 3 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 440
Hs

1 121
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Last updated: 15 Jul 2024