Protein: DCP1A
mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF)

Gene: DCP1A
Organism: Homo sapiens
Interactions: 157
UniProt ID: Q9NPI6

Gene Ontology (top 5):
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0000932 - P-body
GO:0003729 - mRNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1215883

DCP2
m7GpppN-mRNA hydrolase

14

3

Small-scale

0.986

High

1342875

PNRC2
Proline-rich nuclear receptor coactivator 2

9

3

Small-scale

0.977

High

1224190

DCP1B
mRNA-decapping enzyme 1B

7

10

Small-scale

0.963

High

1016561

PNRC1
Proline-rich nuclear receptor coactivator 1

3

3

High-throughput

0.861

High

1342874

DCP1A
mRNA-decapping enzyme 1A

2

9

Small-scale

0.841

High

1290995

EDC3
Enhancer of mRNA-decapping protein 3

15

3

Small-scale

0.764

High

640634

DDX6
Probable ATP-dependent RNA helicase DDX6

11

6

Small-scale

0.760

High

1159012

EDC4
Enhancer of mRNA-decapping protein 4

11

7

Small-scale

0.759

High

1035603

SMAD4
Mothers against decapentaplegic homolog 4

5

3

Small-scale

0.726

High

314157

BAG4
BAG family molecular chaperone regulator 4

5

1

High-throughput

0.723

High

1272361

RENT1
Regulator of nonsense transcripts 1

4

2

Small-scale

0.702

High

1050802

FHL2
Four and a half LIM domains protein 2

4

7

High-throughput

0.698

High

905145

1433G
14-3-3 protein gamma

4

20

High-throughput

0.691

High

507587

PIM1
Serine/threonine-protein kinase pim-1

3

2

High-throughput

0.667

High

927562

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.656

High

1198395

PATL1
Protein PAT1 homolog 1

3

4

Small-scale

0.656

High

982529

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

1224420

XRN1
5'-3' exoribonuclease 1

3

3

Small-scale

0.642

High

1242137

LS14A
Protein LSM14 homolog A

3

8

Small-scale

0.640

High

451570

CLCA
Clathrin light chain A

2

5

High-throughput

0.611

High

644336

TTP
mRNA decay activator protein ZFP36

2

3

Small-scale

0.611

High

683739

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.611

High

910058

1433E
14-3-3 protein epsilon

2

3

High-throughput

0.611

High

1342895

MARF1
Meiosis regulator and mRNA stability factor 1

2

1

High-throughput

0.611

High

1295791

RITA1
RBPJ-interacting and tubulin-associated protein 1

2

0

High-throughput

0.601

High

228786

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.584

High

836013

GSK3B
Glycogen synthase kinase-3 beta

2

6

High-throughput

0.584

High

1187797

ZCCHV
Zinc finger CCCH-type antiviral protein 1

2

5

Small-scale

0.584

High

795512

RAD52
DNA repair protein RAD52 homolog

2

0

High-throughput

0.580

High

742550

SYUA
Alpha-synuclein

2

1

High-throughput

0.571

High

802740

CRK
Adapter molecule crk

2

8

High-throughput

0.571

High

1268701

FAN
Protein FAN

1

4

Small-scale

0.552

High

647691

MK03
Mitogen-activated protein kinase 3

1

3

High-throughput

0.541

High

168149

TBX3
T-box transcription factor TBX3

1

4

High-throughput

0.536

High

451736

CLCB
Clathrin light chain B

1

5

High-throughput

0.536

High

509136

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.536

High

610063

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

7

High-throughput

0.536

High

660715

GRN
Progranulin

1

1

High-throughput

0.536

High

802909

CRKL
Crk-like protein

1

7

High-throughput

0.536

High

960985

CLH1
Clathrin heavy chain 1

1

1

High-throughput

0.536

High

972257

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

1

High-throughput

0.536

High

1024421

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

1

High-throughput

0.515

High

606939

IDS
Iduronate 2-sulfatase

1

0

High-throughput

0.513

High

895286

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.513

High

1251570

PPR35
Protein phosphatase 1 regulatory subunit 35

1

0

High-throughput

0.513

High

1342884

TRM6
tRNA

1

0

High-throughput

0.513

High

1342897

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.513

High

1342900

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

321431

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

2

High-throughput

0.508

High

1342889

TTF2
Transcription termination factor 2

1

6

Small-scale

0.508

High

3542

NBDY
Negative regulator of P-body association

1

1

Small-scale

0.500

High

870051

LIPR2
Pancreatic lipase-related protein 2

1

2

High-throughput

0.489

High

1173248

PAXI1
PAX-interacting protein 1

1

4

High-throughput

0.481

High

62173

RCCD1
RCC1 domain-containing protein 1

1

1

High-throughput

0.479

High

118915

GTPB1
GTP-binding protein 1

1

1

High-throughput

0.479

High

159093

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

1

High-throughput

0.479

High

160199

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

2

High-throughput

0.479

High

163323

XPO1
Exportin-1

1

3

High-throughput

0.479

High

165065

SC16A
Protein transport protein Sec16A

1

8

High-throughput

0.479

High

166320

GRRE1
Granule associated Rac and RHOG effector protein 1

1

1

High-throughput

0.479

High

170486

TIF1A
Transcription intermediary factor 1-alpha

1

4

Small-scale

0.479

High

177089

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

1

Small-scale

0.479

High

232531

KDM1A
Lysine-specific histone demethylase 1A

1

6

High-throughput

0.479

High

257414

CNOT3
CCR4-NOT transcription complex subunit 3

1

4

High-throughput

0.479

High

325903

LATS1
Serine/threonine-protein kinase LATS1

1

2

High-throughput

0.479

High

347971

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

385565

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

387567

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

516707

PABP1
Polyadenylate-binding protein 1

1

5

High-throughput

0.479

High

553792

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

570090

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

610512

CBL
E3 ubiquitin-protein ligase CBL

1

5

High-throughput

0.479

High

647303

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

668998

PML
Protein PML

1

4

High-throughput

0.479

High

684341

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

714079

HS71L
Heat shock 70 kDa protein 1-like

1

1

Small-scale

0.479

High

808952

YAP1
Transcriptional coactivator YAP1

1

4

High-throughput

0.479

High

823498

PAXI
Paxillin

1

7

High-throughput

0.479

High

835530

GSK3A
Glycogen synthase kinase-3 alpha

1

5

High-throughput

0.479

High

850716

KS6A3
Ribosomal protein S6 kinase alpha-3

1

1

High-throughput

0.479

High

1026547

RFA4
Replication protein A 30 kDa subunit

1

3

High-throughput

0.479

High

1031472

PABP4
Polyadenylate-binding protein 4

1

5

High-throughput

0.479

High

1038738

HDAC1
Histone deacetylase 1

1

1

High-throughput

0.479

High

1074419

STIL
SCL-interrupting locus protein

1

1

High-throughput

0.479

High

1080792

ZYX
Zyxin

1

8

High-throughput

0.479

High

1109637

LSM12
Protein LSM12

1

1

High-throughput

0.479

High

1144787

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

3

High-throughput

0.479

High

1159100

CEP85
Centrosomal protein of 85 kDa

1

2

High-throughput

0.479

High

1168848

MEX3B
RNA-binding protein MEX3B

1

1

High-throughput

0.479

High

1171833

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1173970

RAPH1
Ras-associated and pleckstrin homology domains-containing protein 1

1

3

High-throughput

0.479

High

1188900

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1192386

YTHD3
YTH domain-containing family protein 3

1

5

High-throughput

0.479

High

1200681

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1230046

RPTOR
Regulatory-associated protein of mTOR

1

3

High-throughput

0.479

High

1232134

RHG18
Rho GTPase-activating protein 18

1

1

High-throughput

0.479

High

1242665

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

10

High-throughput

0.479

High

1245198

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

1254003

ALMS1
Centrosome-associated protein ALMS1

1

4

High-throughput

0.479

High

1262725

ATX2L
Ataxin-2-like protein

1

6

High-throughput

0.479

High

1263186

PALLD
Palladin

1

2

High-throughput

0.479

High

1266695

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

1

High-throughput

0.479

High

1269695

ESR2
Estrogen receptor beta

1

14

High-throughput

0.479

High

1271668

DDX17
Probable ATP-dependent RNA helicase DDX17

1

1

Small-scale

0.479

High

1274171

LPP
Lipoma-preferred partner

1

8

High-throughput

0.479

High

1305698

ATX2
Ataxin-2

1

7

High-throughput

0.479

High

1306594

TS101
Tumor susceptibility gene 101 protein

1

1

High-throughput

0.479

High

1314946

LS14B
Protein LSM14 homolog B

1

5

High-throughput

0.479

High

1317744

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

5

High-throughput

0.479

High

1331366

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

1334277

AGO3
Protein argonaute-3

1

2

High-throughput

0.479

High

1335183

RC3H2
Roquin-2

1

6

High-throughput

0.479

High

1335974

MOV10
Helicase MOV-10

1

2

High-throughput

0.479

High

1336199

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

10

High-throughput

0.479

High

1342877

KI13B
Kinesin-like protein KIF13B

1

3

High-throughput

0.479

High

1342882

TBK1
Serine/threonine-protein kinase TBK1

1

2

High-throughput

0.479

High

1342885

RCOR1
REST corepressor 1

1

6

High-throughput

0.479

High

1342886

AGO2
Protein argonaute-2

1

2

High-throughput

0.479

High

1342887

AGO1
Protein argonaute-1

1

2

High-throughput

0.479

High

1342890

TRI33
E3 ubiquitin-protein ligase TRIM33

1

4

High-throughput

0.479

High

1342891

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

8

High-throughput

0.479

High

1342892

SMG5
Nonsense-mediated mRNA decay factor SMG5

1

1

High-throughput

0.479

High

1342893

FBW1A
F-box/WD repeat-containing protein 1A

1

3

High-throughput

0.479

High

1342894

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

1342896

TRAF6
TNF receptor-associated factor 6

1

1

Small-scale

0.479

High

1342899

YTHD2
YTH domain-containing family protein 2

1

5

High-throughput

0.479

High

61477

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.458

High

417029

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.458

High

437804

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

1

0

High-throughput

0.458

High

780154

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

870695

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

1063124

ABRX2
BRISC complex subunit Abraxas 2

1

0

High-throughput

0.458

High

1075997

PCH2
Pachytene checkpoint protein 2 homolog

1

0

High-throughput

0.458

High

1101311

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1129599

SMAG2
Protein Smaug homolog 2

1

0

High-throughput

0.458

High

1135894

TUT4
Terminal uridylyltransferase 4

1

0

High-throughput

0.458

High

1230183

CNTRB
Centrobin

1

0

High-throughput

0.458

High

1243203

DUS18
Dual specificity protein phosphatase 18

1

0

High-throughput

0.458

High

1306996

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

1332648

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1336247

Q9HCK3
KIAA1569 protein

1

0

High-throughput

0.458

High

1342876

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

Small-scale

0.458

High

1342878

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

1342881

AASS
Alpha-aminoadipic semialdehyde synthase, mitochondrial

1

0

High-throughput

0.458

High

1342883

EI2BD
Translation initiation factor eIF2B subunit delta

1

0

High-throughput

0.458

High

1342888

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.458

High

1044175

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.445

High

1153395

PKHA7
Pleckstrin homology domain-containing family A member 7

1

7

High-throughput

0.445

High

721521

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1285366

PF21A
PHD finger protein 21A

1

8

High-throughput

0.437

High

1342898

KCTD3
BTB/POZ domain-containing protein KCTD3

1

2

High-throughput

0.437

High

276571

PPR37
Protein phosphatase 1 regulatory subunit 37

1

0

High-throughput

0.279

Low

873486

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

High-throughput

0.279

Low

1251182

G45IP
Large ribosomal subunit protein mL64

1

0

High-throughput

0.279

Low

1342880

TAP26
Thyroid transcription factor 1-associated protein 26

1

0

High-throughput

0.279

Low

1342879

PSD3
PH and SEC7 domain-containing protein 3

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024