Protein: NKX31
Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A)

Gene: NKX31, NKX3-1
Organism: Homo sapiens
Interactions: 55
UniProt ID: Q99801

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1407365

RHXF2
Rhox homeobox family member 2

2

19

High-throughput

0.783

High

542182

TOP1
DNA topoisomerase 1

3

4

Small-scale

0.686

High

520325

ANDR
Androgen receptor

3

19

Small-scale

0.640

High

1102240

ATM
Serine-protein kinase ATM

2

3

Small-scale

0.624

High

331520

SPDEF
SAM pointed domain-containing Ets transcription factor

2

20

Small-scale

0.619

High

549347

SRF
Serum response factor

1

5

Small-scale

0.618

High

1347716

ZN417
Zinc finger protein 417

2

6

High-throughput

0.606

High

1005021

RNF4
E3 ubiquitin-protein ligase RNF4

2

0

High-throughput

0.580

High

1407367

TOPRS
E3 ubiquitin-protein ligase Topors

1

4

Small-scale

0.536

High

1396291

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

19

Small-scale

0.536

High

926683

HIRA
Protein HIRA

1

17

High-throughput

0.515

High

1407364

MEP50
Methylosome protein WDR77

1

12

Small-scale

0.501

High

404373

GCR
Glucocorticoid receptor

1

20

Small-scale

0.500

High

1330217

ZN655
Zinc finger protein 655

1

6

Small-scale

0.500

High

1404722

RING2
E3 ubiquitin-protein ligase RING2

1

14

Small-scale

0.500

High

1407366

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

15

Small-scale

0.500

High

144066

MA2B1
Lysosomal alpha-mannosidase

1

1

Small-scale

0.481

High

465030

SP1
Transcription factor Sp1

1

17

Small-scale

0.481

High

476790

RSSA
Small ribosomal subunit protein uS2

1

1

Small-scale

0.481

High

565536

RARG
Retinoic acid receptor gamma

1

18

Small-scale

0.481

High

573643

ENPL
Endoplasmin

1

1

Small-scale

0.481

High

717340

PEBP1
Phosphatidylethanolamine-binding protein 1

1

1

Small-scale

0.481

High

1034883

SP2
Transcription factor Sp2

1

15

Small-scale

0.481

High

1036860

SP4
Transcription factor Sp4

1

19

Small-scale

0.481

High

1036900

SP3
Transcription factor Sp3

1

16

Small-scale

0.481

High

1096379

ROA0
Heterogeneous nuclear ribonucleoprotein A0

1

2

Small-scale

0.481

High

1231300

SP5
Transcription factor Sp5

1

20

Small-scale

0.481

High

1407369

LMCD1
LIM and cysteine-rich domains protein 1

1

4

Small-scale

0.481

High

1407370

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

20

Small-scale

0.481

High

1407371

FEM1B
Protein fem-1 homolog B

1

11

Small-scale

0.481

High

892928

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.480

High

723066

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

Small-scale

0.479

High

1152608

ELAV1
ELAV-like protein 1

1

0

Small-scale

0.479

High

1393260

SENP5
Sentrin-specific protease 5

1

0

Small-scale

0.479

High

396799

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

1101885

SKP2
S-phase kinase-associated protein 2

1

6

Small-scale

0.479

High

1110031

HDAC1
Histone deacetylase 1

1

11

Small-scale

0.479

High

1158167

MK14
Mitogen-activated protein kinase 14

1

3

Small-scale

0.479

High

1369202

KAT2B
Histone acetyltransferase KAT2B

1

4

Small-scale

0.479

High

70874

CENPX
Centromere protein X

1

0

Small-scale

0.460

High

567470

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.460

High

635802

PTMS
Parathymosin

1

0

Small-scale

0.460

High

908776

MAT1
CDK-activating kinase assembly factor MAT1

1

0

Small-scale

0.460

High

961815

RL37A
Large ribosomal subunit protein eL43

1

0

Small-scale

0.460

High

1191610

RABL6
Rab-like protein 6

1

0

Small-scale

0.460

High

1315949

CHSS2
Chondroitin sulfate synthase 2

1

0

Small-scale

0.460

High

1355870

AEN
Apoptosis-enhancing nuclease

1

0

Small-scale

0.460

High

1407363

TCPH
T-complex protein 1 subunit eta

1

0

Small-scale

0.460

High

1407368

STMN3
Stathmin-3

1

0

Small-scale

0.460

High

1407372

TX264
Testis-expressed protein 264

1

0

Small-scale

0.460

High

1058617

CKAP4
Cytoskeleton-associated protein 4

1

2

Small-scale

0.439

High

1385332

F136A
Protein FAM136A

2

0

High-throughput

0.328

High

1246356

MO2R2
Cell surface glycoprotein CD200 receptor 2

2

0

High-throughput

0.316

High

1384624

S67A1
Solute carrier family 67 member A1

2

0

High-throughput

0.316

High

397700

NU4M
NADH-ubiquinone oxidoreductase chain 4

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025