HitPredict

Interactor 1: PAX5 (Q02548)
Paired box protein Pax-5 (B-cell-specific transcription factor) (BSAP)
Gene: PAX5

Interactor 2: TLE4 (Q04727)
Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4)
Gene: TLE4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.636

Property	Details
Experiments	10811620, 12153506
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 391 Hs			1 773
+	Hs
		685164 PAX6_HUMAN (13-391): 2.13e-88: 275: 33.95		TLE4_HUMAN (1-773): 0: 637: 100.00
+	Hs
		662217 PAX7_HUMAN (7-387): 2.35e-85: 270: 35.89		TLE4_HUMAN (1-773): 0: 637: 100.00
+	Mm
		666052 PAX3_MOUSE (7-380): 4.28e-83: 263: 35.64		TLE4_MOUSE (1-773): 0: 638: 99.61
+	Hs
		1040040 PAX2_HUMAN (1-391): 1.07e-90: 281: 63.88		TLE1_HUMAN (8-773): 0: 592: 86.27
+	Hs
		685162 PAX6_HUMAN (13-391): 2.13e-88: 275: 33.95		TLE1_HUMAN (8-773): 0: 592: 86.27
+	Hs
		662215 PAX7_HUMAN (7-387): 2.35e-85: 270: 35.89		TLE1_HUMAN (8-773): 0: 592: 86.27
+	Hs
		1048150 PAX8_HUMAN (12-389): 3.59e-64: 213: 49.00		TLE4_HUMAN (1-773): 0: 637: 100.00
+	Hs
		1040041 PAX2_HUMAN (1-391): 1.07e-90: 281: 63.88		TLE3_HUMAN (8-773): 0: 556: 81.08
+	Hs
		685163 PAX6_HUMAN (13-391): 2.13e-88: 275: 33.95		TLE3_HUMAN (8-773): 0: 556: 81.08
+	Hs
		662216 PAX7_HUMAN (7-387): 2.35e-85: 270: 35.89		TLE3_HUMAN (8-773): 0: 556: 81.08
+	Hs
		1047800 PAX8_HUMAN (12-389): 3.59e-64: 213: 49.00		TLE1_HUMAN (8-773): 0: 592: 86.27
+	Hs
		1047954 PAX8_HUMAN (12-389): 3.59e-64: 213: 49.00		TLE3_HUMAN (8-773): 0: 556: 81.08
+	Hs
		1040044 PAX2_HUMAN (1-391): 1.07e-90: 281: 63.88		TLE5_HUMAN (8-205): 2.2e-93: 291: 67.68
+	Hs
		685170 PAX6_HUMAN (13-391): 2.13e-88: 275: 33.95		TLE5_HUMAN (8-205): 2.2e-93: 291: 67.68
+	Hs
		662219 PAX7_HUMAN (7-387): 2.35e-85: 270: 35.89		TLE5_HUMAN (8-205): 2.2e-93: 291: 67.68
+	Mm
		866404 PAX7_MOUSE (7-387): 6.48e-89: 279: 36.07		WDR5_MOUSE (525-771): 1.68e-85: 276: 17.72
+	Hs
		662211 PAX7_HUMAN (7-387): 2.35e-85: 270: 35.89		WDR5_HUMAN (525-771): 1.68e-85: 276: 17.72
+	Hs
		261369 PAX6_HUMAN (13-391): 2.13e-88: 275: 33.95		TBL1X_HUMAN (243-732): 5.21e-80: 269: 11.86
+	Hs
		261365 PAX7_HUMAN (7-387): 2.35e-85: 270: 35.89		TBL1X_HUMAN (243-732): 5.21e-80: 269: 11.86
+	Ce
		111450 PAX3H_CAEEL (15-322): 1.01e-70: 225: 29.45		UNC37_CAEEL (24-773): 6.09e-96: 312: 36.33