HitPredict

Interactor 1: MYH6 (Q02566)
Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha)
Gene: MYH6

Interactor 2: MYH1 (Q5SX40)
Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain, skeletal muscle, adult 1)
Gene: MYH1

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29199018
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Myosin_head~Myosin_head, Myosin_N~Myosin_head, Myosin_head~Myosin_tail_1, Myosin_N~Myosin_tail_1, Myosin_tail_1~Myosin_tail_1
Common GO terms	GO:0005516 - calmodulin binding GO:0005524 - ATP binding GO:0032982 - myosin filament GO:0051015 - actin filament binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1938 Mm			1 1942
+	Rn
		386940 MYH6_RAT (1-1938): 0: 1196: 98.50		MYH6_RAT (3-1942): 0: 1179: 80.74
+	Hs
		562992 MYH6_HUMAN (1-1938): 0: 1196: 96.75		MYH6_HUMAN (3-1942): 0: 1179: 80.43
+	Mm
		1037830 MYH6_MOUSE (1-1938): 0: 1193: 100.00		MYH6_MOUSE (3-1937): 0: 1171: 80.88
+	Hs
		556892 MYH7_HUMAN (983-1938): 1.42e-64: 246: 18.96		MYH7_HUMAN (3-1942): 0: 1209: 81.19
+	Hs
		556973 MYH7_HUMAN (983-1938): 1.42e-64: 246: 18.96		MYH4_HUMAN (1-1942): 0: 1194: 93.41
+	Mm
		563088 MYH6_MOUSE (1-1938): 0: 1193: 100.00		MYH8_MOUSE (962-1942): 2.09e-60: 232: 17.35
+	Hs
		535921 MYH6_HUMAN (1-1938): 0: 1196: 96.75		MYH3_HUMAN (1376-1941): 2.2e-32: 140: 15.79
+	Mm
		59762 MYH6_MOUSE (1-1938): 0: 1193: 100.00		MYH7B_MOUSE (739-1188): 3.85e-15: 83.9: 12.20
+	Hs
		773112 MYH11_HUMAN (955-1938): 6.19e-62: 237: 19.70		MYH10_HUMAN (932-1941): 6.46e-64: 244: 19.71
+	Hs
		556902 MYH7_HUMAN (983-1938): 1.42e-64: 246: 18.96		MYH9_HUMAN (1110-1941): 2e-56: 219: 15.38
+	Hs
		563081 MYH4_HUMAN (957-1938): 4.84e-61: 234: 17.48		MYH8_HUMAN (962-1942): 7.39e-60: 230: 16.95
+	Hs
		772645 MYH9_HUMAN (1054-1936): 2.63e-54: 212: 15.13		MYH10_HUMAN (932-1941): 6.46e-64: 244: 19.71
+	Hs
		772647 MYH11_HUMAN (955-1938): 6.19e-62: 237: 19.70		MYH9_HUMAN (1110-1941): 2e-56: 219: 15.38
+	Hs
		772644 MYH9_HUMAN (1054-1936): 2.63e-54: 212: 15.13		MYH9_HUMAN (1110-1941): 2e-56: 219: 15.38
+	Hs
		535958 MYH4_HUMAN (957-1938): 4.84e-61: 234: 17.48		MYH3_HUMAN (1376-1941): 2.2e-32: 140: 15.79
+	Ce
		386955 MYO2_CAEEL (1014-1938): 4.58e-58: 224: 16.96		MYO1_CAEEL (718-1389): 1.62e-24: 114: 13.38
+	Hs
		776829 MYH11_HUMAN (955-1938): 6.19e-62: 237: 19.70		MYH14_HUMAN (785-1414): 3.54e-20: 100: 15.12