HitPredict

Interactor 1: RIPK1 (Q13546)
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Gene: RIPK1

Interactor 2: CARD6 (Q9BX69)
Caspase recruitment domain-containing protein 6
Gene: CARD6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16418290
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CARD~Death
Common GO terms	GO:0006915 - apoptotic process
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 671 Hs			1 1037
+	Hs
		201826 RIPK2_HUMAN (60-306): 4.47e-30: 127: 32.96		CARD6_HUMAN (1-1037): 0: 1101: 100.00
+	Hs
		302242 IGF1R_HUMAN (20-312): 1.02e-26: 118: 31.21		SC31A_HUMAN (635-1011): 7.56e-30: 130: 9.14
+	Mm
		93242 RIPK2_MOUSE (55-369): 5.14e-32: 132: 29.57		E9PWH2_MOUSE (584-1035): 1.92e-20: 99: 13.65
+	Mm
		93243 Q547H1_MOUSE (55-369): 5.14e-32: 132: 29.57		E9PWH2_MOUSE (584-1035): 1.92e-20: 99: 13.65
+	Hs
		297808 LYN_HUMAN (23-289): 6.17e-28: 120: 32.13		K0754_HUMAN (603-934): 1.01e-19: 98.1: 10.36
+	Mm
		101430 CSK_MOUSE (10-285): 2.8e-28: 120: 31.10		F8VPR5_MOUSE (739-1035): 1.68e-11: 71.1: 14.14
+	Hs
		433930 LYN_HUMAN (23-289): 6.17e-28: 120: 32.13		CBP_HUMAN (767-1036): 1.95e-11: 70.7: 8.83
+	Mm
		101424 LYN_MOUSE (22-289): 6.81e-27: 117: 31.30		F8VPR5_MOUSE (739-1035): 1.68e-11: 71.1: 14.14
+	Mm
		639457 LYN_MOUSE (22-289): 6.81e-27: 117: 31.30		RBM12_MOUSE (889-1035): 7.13e-10: 65.3: 16.89
+	Hs
		433891 LYN_HUMAN (23-289): 6.17e-28: 120: 32.13		MINK1_HUMAN (817-1032): 8.01e-09: 62.2: 16.16
+	Hs
		411694 LCK_HUMAN (23-289): 1.31e-27: 119: 31.87		EP300_HUMAN (644-1026): 7.98e-09: 62.2: 9.42
+	Hs
		411790 LCK_HUMAN (23-289): 1.31e-27: 119: 31.87		MINK1_HUMAN (817-1032): 8.01e-09: 62.2: 16.16