Protein: MP2K7
Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2)

Gene: MP2K7, MAP2K7
Organism: Homo sapiens
Interactions: 182
UniProt ID: O14733

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004707 - MAP kinase activity
GO:0004708 - MAP kinase kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

161960

MK08
Mitogen-activated protein kinase 8

9

20

Small-scale

0.979

High

161983

M3K1
Mitogen-activated protein kinase kinase kinase 1

3

20

Small-scale

0.834

High

161953

MK01
Mitogen-activated protein kinase 1

3

20

Small-scale

0.825

High

162003

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

20

Small-scale

0.825

High

161961

MK09
Mitogen-activated protein kinase 9

3

20

Small-scale

0.820

High

161932

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.789

High

161933

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.789

High

162000

M3K11
Mitogen-activated protein kinase kinase kinase 11

2

14

Small-scale

0.778

High

161939

BRAF
Serine/threonine-protein kinase B-raf

2

20

Small-scale

0.768

High

162018

DUS19
Dual specificity protein phosphatase 19

2

9

Small-scale

0.768

High

162061

M3K2
Mitogen-activated protein kinase kinase kinase 2

2

16

Small-scale

0.768

High

162050

M3K20
Mitogen-activated protein kinase kinase kinase 20

2

16

Small-scale

0.759

High

162030

M3K5
Mitogen-activated protein kinase kinase kinase 5

2

17

Small-scale

0.754

High

161982

M3K12
Mitogen-activated protein kinase kinase kinase 12

1

19

Small-scale

0.724

High

162060

VSIG4
V-set and immunoglobulin domain-containing protein 4

2

1

High-throughput

0.705

High

74393

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

5

High-throughput

0.691

High

161949

DNJB1
DnaJ homolog subfamily B member 1

1

20

High-throughput

0.691

High

161970

RAB7A
Ras-related protein Rab-7a

1

7

High-throughput

0.691

High

161979

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

20

High-throughput

0.691

High

161986

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

20

High-throughput

0.691

High

161991

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

20

High-throughput

0.691

High

161997

DDB1
DNA damage-binding protein 1

1

4

High-throughput

0.691

High

161999

CDC37
Hsp90 co-chaperone Cdc37

1

13

High-throughput

0.691

High

162009

VRK2
Serine/threonine-protein kinase VRK2

1

19

Small-scale

0.691

High

162025

CANB2
Calcineurin subunit B type 2

1

11

High-throughput

0.691

High

162036

CLPB
Mitochondrial disaggregase

1

3

High-throughput

0.691

High

161978

DLK1
Protein delta homolog 1

4

5

High-throughput

0.691

High

162058

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

3

10

Small-scale

0.678

High

161962

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

17

Small-scale

0.665

High

161903

M3K13
Mitogen-activated protein kinase kinase kinase 13

1

17

Small-scale

0.647

High

161998

MK14
Mitogen-activated protein kinase 14

1

20

Small-scale

0.647

High

162033

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

16

Small-scale

0.647

High

162069

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

16

Small-scale

0.647

High

162057

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

3

20

Small-scale

0.646

High

161984

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

2

15

Small-scale

0.629

High

162015

TPC2
Two pore channel protein 2

2

2

High-throughput

0.628

High

161910

GA45B
Growth arrest and DNA damage-inducible protein GADD45 beta

2

0

Small-scale

0.625

High

161901

GP182
G-protein coupled receptor 182

1

7

High-throughput

0.618

High

161954

NK3R
Neuromedin-K receptor

1

2

High-throughput

0.618

High

161969

RAB5C
Ras-related protein Rab-5C

1

4

High-throughput

0.618

High

161990

RCN2
Reticulocalbin-2

1

15

High-throughput

0.618

High

162013

DJC10
DnaJ homolog subfamily C member 10

1

4

High-throughput

0.618

High

161902

CFLAR
CASP8 and FADD-like apoptosis regulator

1

9

Small-scale

0.618

High

161904

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

20

Small-scale

0.618

High

161907

PRKN
E3 ubiquitin-protein ligase parkin

1

19

High-throughput

0.618

High

161926

RASN
GTPase NRas

1

14

Small-scale

0.618

High

161994

KS6A2
Ribosomal protein S6 kinase alpha-2

1

17

High-throughput

0.618

High

161995

KS6A1
Ribosomal protein S6 kinase alpha-1

1

17

High-throughput

0.618

High

162006

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.618

High

162026

TRIB3
Tribbles homolog 3

1

16

Small-scale

0.618

High

162039

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

162055

ALK
ALK tyrosine kinase receptor

1

12

Small-scale

0.618

High

161898

XPO1
Exportin-1

2

19

High-throughput

0.611

High

161929

FRIL
Ferritin light chain

2

2

High-throughput

0.601

High

161946

PROZ
Vitamin K-dependent protein Z

2

4

High-throughput

0.574

High

161992

I13R2
Interleukin-13 receptor subunit alpha-2

2

4

High-throughput

0.574

High

162059

LAMP3
Lysosome-associated membrane glycoprotein 3

2

3

High-throughput

0.574

High

162005

A16L1
Autophagy-related protein 16-1

2

14

High-throughput

0.571

High

161967

RBP2
E3 SUMO-protein ligase RanBP2

1

6

Small-scale

0.561

High

129909

PGRC1
Membrane-associated progesterone receptor component 1

2

2

Small-scale

0.558

High

161944

C4BPB
C4b-binding protein beta chain

2

1

High-throughput

0.558

High

161957

BASI
Basigin

2

3

High-throughput

0.558

High

162041

ANTR1
Anthrax toxin receptor 1

2

1

High-throughput

0.558

High

162011

ZDH17
Palmitoyltransferase ZDHHC17

1

11

Small-scale

0.553

High

161909

LPXN
Leupaxin

1

9

High-throughput

0.541

High

161976

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.541

High

50438

HACL2
2-hydroxyacyl-CoA lyase 2

1

4

High-throughput

0.536

High

124686

AIP
AH receptor-interacting protein

1

19

High-throughput

0.536

High

161897

ANM5
Protein arginine N-methyltransferase 5

1

3

High-throughput

0.536

High

161899

SC16A
Protein transport protein Sec16A

1

2

High-throughput

0.536

High

161900

PFD6
Prefoldin subunit 6

1

1

High-throughput

0.536

High

161908

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

1

High-throughput

0.536

High

161917

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

High-throughput

0.536

High

161918

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

5

High-throughput

0.536

High

161919

ACSL3
Fatty acid CoA ligase Acsl3

1

1

High-throughput

0.536

High

161925

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

High-throughput

0.536

High

161928

GLPA
Glycophorin-A

1

1

High-throughput

0.536

High

161930

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

5

High-throughput

0.536

High

161934

ANXA5
Annexin A5

1

7

High-throughput

0.536

High

161940

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

5

High-throughput

0.536

High

161941

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

6

High-throughput

0.536

High

161943

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

2

High-throughput

0.536

High

161947

TBG1
Tubulin gamma-1 chain

1

20

High-throughput

0.536

High

161950

PYR1
Multifunctional protein CAD

1

8

High-throughput

0.536

High

161959

LONM
Lon protease homolog, mitochondrial

1

5

High-throughput

0.536

High

161963

MAP1B
Microtubule-associated protein 1B

1

7

High-throughput

0.536

High

161968

F10A1
Hsc70-interacting protein

1

20

High-throughput

0.536

High

161972

KAD2
Adenylate kinase 2, mitochondrial

1

5

High-throughput

0.536

High

161974

DCAF7
DDB1- and CUL4-associated factor 7

1

8

High-throughput

0.536

High

161977

PRKDC
DNA-dependent protein kinase catalytic subunit

1

15

High-throughput

0.536

High

161980

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

2

High-throughput

0.536

High

161981

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

11

High-throughput

0.536

High

161987

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

161989

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

3

High-throughput

0.536

High

161993

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.536

High

162004

NU188
Nucleoporin NUP188

1

1

High-throughput

0.536

High

162010

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

20

High-throughput

0.536

High

162012

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

7

High-throughput

0.536

High

162021

GCN1
Stalled ribosome sensor GCN1

1

19

High-throughput

0.536

High

162022

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.536

High

162023

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

1

High-throughput

0.536

High

162027

TCPQM
T-complex protein 1 subunit theta-like 2

1

20

High-throughput

0.536

High

162028

MMS19
MMS19 nucleotide excision repair protein homolog

1

1

High-throughput

0.536

High

162029

CDC5L
Cell division cycle 5-like protein

1

9

High-throughput

0.536

High

162032

NPAS1
Neuronal PAS domain-containing protein 1

1

14

High-throughput

0.536

High

162042

CYBP
Calcyclin-binding protein

1

2

High-throughput

0.536

High

162046

PDLI7
PDZ and LIM domain protein 7

1

10

High-throughput

0.536

High

162049

APC11
Anaphase-promoting complex subunit 11

1

2

High-throughput

0.536

High

162054

AKP8L
A-kinase anchor protein 8-like

1

4

High-throughput

0.536

High

162056

CHIP
E3 ubiquitin-protein ligase CHIP

1

8

High-throughput

0.536

High

162062

SGT1
Protein SGT1 homolog

1

11

High-throughput

0.536

High

162064

RTCB
RNA-splicing ligase RtcB homolog

1

1

High-throughput

0.536

High

162065

YTHD2
YTH domain-containing family protein 2

1

3

High-throughput

0.536

High

161942

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

High-throughput

0.518

High

161922

BCL10
B-cell lymphoma/leukemia 10

1

4

Small-scale

0.515

High

161935

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.513

High

161964

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

0

High-throughput

0.513

High

161971

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.513

High

162031

METH
Methionine synthase

1

0

High-throughput

0.513

High

162034

F174C
Protein FAM174C

1

0

High-throughput

0.513

High

161931

JUN
Transcription factor Jun

1

8

Small-scale

0.501

High

161937

TAU
Microtubule-associated protein tau

1

20

Small-scale

0.501

High

124139

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.489

High

137556

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

1

High-throughput

0.489

High

161906

CALU
Calumenin

1

8

High-throughput

0.489

High

161913

FCN3
Ficolin-3

1

6

High-throughput

0.489

High

161915

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

1

High-throughput

0.489

High

161938

GLU2B
Glucosidase 2 subunit beta

1

2

High-throughput

0.489

High

161945

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

1

High-throughput

0.489

High

161951

CALX
Calnexin

1

4

High-throughput

0.489

High

161973

ATPK
ATP synthase F(0) complex subunit f, mitochondrial

1

1

High-throughput

0.489

High

161985

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.489

High

162014

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

3

High-throughput

0.489

High

162020

S39A7
Zinc transporter SLC39A7

1

2

High-throughput

0.489

High

162037

CPVL
Probable serine carboxypeptidase CPVL

1

3

High-throughput

0.489

High

162066

PCDB6
Protocadherin beta-6

1

1

High-throughput

0.489

High

162067

PCDG5
Protocadherin gamma-A5

1

1

High-throughput

0.489

High

162068

TF3C3
General transcription factor 3C polypeptide 3

1

4

High-throughput

0.489

High

161952

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

13

Small-scale

0.484

High

2082

TVA20
T cell receptor alpha variable 20

1

0

High-throughput

0.481

High

161905

WDR62
WD repeat-containing protein 62

1

13

Small-scale

0.479

High

161914

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

161916

LTN1
E3 ubiquitin-protein ligase listerin

1

1

High-throughput

0.479

High

161920

BRD1
Bromodomain-containing protein 1

1

4

High-throughput

0.479

High

161936

H2A1
Histone H2A type 1

1

5

High-throughput

0.479

High

161948

SP100
Nuclear autoantigen Sp-100

1

7

High-throughput

0.479

High

161955

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

161956

STIP1
Stress-induced-phosphoprotein 1

1

11

High-throughput

0.479

High

161975

1433E
14-3-3 protein epsilon

1

14

High-throughput

0.479

High

161988

CUL3
Cullin-3

1

11

High-throughput

0.479

High

162001

CL16A
Protein CLEC16A

1

5

High-throughput

0.479

High

162008

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

162017

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

12

Small-scale

0.479

High

162019

TP8L1
Tumor necrosis factor alpha-induced protein 8-like protein 1

1

1

Small-scale

0.479

High

162024

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

162045

WDR6
tRNA

1

20

Small-scale

0.479

High

162047

FBX6
F-box only protein 6

1

2

High-throughput

0.479

High

162052

XPO7
Exportin-7

1

16

High-throughput

0.479

High

161924

MOC2A
Molybdopterin synthase sulfur carrier subunit

1

0

High-throughput

0.458

High

161958

ARRC
Arrestin-C

1

10

High-throughput

0.457

High

838

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.445

High

58757

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

4

High-throughput

0.445

High

161923

MOC2B
Molybdopterin synthase catalytic subunit

1

2

High-throughput

0.445

High

161965

PP2BC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

1

17

High-throughput

0.445

High

162040

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.445

High

161966

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

162007

SV2B
Synaptic vesicle glycoprotein 2B

1

2

High-throughput

0.407

High

162043

SACA1
Sperm acrosome membrane-associated protein 1

3

0

High-throughput

0.347

High

161911

SC22B
Vesicle-trafficking protein SEC22b

1

0

High-throughput

0.279

Low

161912

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.279

Low

161996

AAAT
Neutral amino acid transporter B(0)

1

0

High-throughput

0.279

Low

162016

ADA32
Disintegrin and metalloproteinase domain-containing protein 32

1

0

High-throughput

0.279

Low

162035

CF062
Uncharacterized protein C6orf62

1

0

High-throughput

0.279

Low

162038

TRABD
TraB domain-containing protein

1

0

High-throughput

0.279

Low

162044

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.279

Low

162048

RM16
Large ribosomal subunit protein uL16m

1

0

High-throughput

0.279

Low

162051

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

0

High-throughput

0.279

Low

162063

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.279

Low

161927

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

162053

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.249

Low

161921

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.232

Low

162002

S45A4
Solute carrier family 45 member 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025