HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: MIER3 (Q7Z3K6)
Mesoderm induction early response protein 3 (Mi-er3)
Gene: MIER3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.909

Property	Details
Experiments	28514442, 33961781, 35271311, 23752268
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ELM2~Hist_deacetyl, Hist_deacetyl~Myb_DNA-binding
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0032991 - protein-containing complex and 1 others more... GO:0042826 - histone deacetylase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 482 Hs			1 550
+	Hs
		1038533 HDAC1_HUMAN (1-482): 0: 668: 100.00		MIER2_HUMAN (2-550): 3.12e-128: 387: 36.41
+	Hs
		1038676 HDAC1_HUMAN (1-482): 0: 668: 100.00		MTA3_HUMAN (81-484): 5.68e-112: 347: 18.31
+	Hs
		1038852 HDAC1_HUMAN (1-482): 0: 668: 100.00		NCOR2_HUMAN (13-524): 1.73e-104: 347: 12.88
+	Hs
		91458 HDAC1_HUMAN (1-482): 0: 668: 100.00		E7EQY4_HUMAN (81-484): 4.99e-112: 344: 18.31
+	Hs
		1038525 HDAC1_HUMAN (1-482): 0: 668: 100.00		MIER1_HUMAN (1-511): 1.94e-106: 330: 43.64
+	Hs
		1031849 HDAC1_HUMAN (1-482): 0: 668: 100.00		MTA1_HUMAN (102-511): 9.79e-99: 316: 16.63
+	Mm
		140302 HDAC1_MOUSE (1-482): 0: 672: 99.38		MTA1_MOUSE (100-511): 3.05e-97: 312: 16.32
+	Hs
		1031919 HDAC2_HUMAN (1-478): 0: 666: 85.92		MTA1_HUMAN (102-511): 9.79e-99: 316: 16.63
+	Mm
		140317 HDAC1_MOUSE (1-482): 0: 672: 99.38		MTA2_MOUSE (78-493): 1.05e-94: 304: 15.98
+	Hs
		296017 HDAC1_HUMAN (1-482): 0: 668: 100.00		MTA2_HUMAN (78-493): 5.53e-94: 302: 16.21
+	Hs
		296092 HDAC2_HUMAN (1-478): 0: 666: 85.92		MTA2_HUMAN (78-493): 5.53e-94: 302: 16.21
+	Hs
		1038768 HDAC1_HUMAN (1-482): 0: 668: 100.00		RCOR3_HUMAN (176-524): 7.69e-83: 268: 19.49
+	Mm
		140301 HDAC1_MOUSE (1-482): 0: 672: 99.38		RCOR1_MOUSE (142-524): 8.95e-72: 239: 17.48
+	Hs
		1038801 HDAC1_HUMAN (1-482): 0: 668: 100.00		RCOR1_HUMAN (142-524): 1.87e-71: 238: 17.22
+	Hs
		1038521 HDAC1_HUMAN (1-482): 0: 668: 100.00		RCOR2_HUMAN (127-524): 1.96e-69: 234: 16.92
+	Mm
		140291 HDAC1_MOUSE (1-482): 0: 672: 99.38		RERE_MOUSE (114-516): 8.86e-62: 222: 14.15
+	Hs
		1038770 HDAC1_HUMAN (1-482): 0: 668: 100.00		RERE_HUMAN (114-516): 1.07e-62: 225: 14.62
+	Hs
		1038636 HDAC1_HUMAN (1-482): 0: 668: 100.00		TREF1_HUMAN (67-466): 1.53e-61: 221: 18.35
+	Hs
		1038472 HDAC1_HUMAN (1-482): 0: 668: 100.00		MDEAS_HUMAN (65-497): 3.5e-59: 214: 15.77
+	Hs
		261500 HDAC1_HUMAN (1-482): 0: 668: 100.00		NCOR1_HUMAN (278-523): 3.27e-10: 65.5: 14.98