Interactor 1: ANGP2 (O15123)
Angiopoietin-2 (ANG-2)
Gene: ANGPT2
Interactor 2: TIE2 (Q02763)
Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b)
Gene: TEK
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 1.00 | 0.973 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25237190, 12427764, 9723709, 9204896, 15893672, 16732286, 20708158 |
| Identification Methods | pull down, affinity chromatography technology, molecular sieving, dynamic light scattering, cosedimentation in solution, x-ray crystallography, enzyme linked immunosorbent assay, surface plasmon resonance |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Fibrinogen_C~fn3 |
| Common GO terms | GO:0001525 - angiogenesis GO:0005576 - extracellular region GO:0016525 - negative regulation of angiogenesis GO:0045766 - positive regulation of angiogenesis GO:0048014 - Tie signaling pathway and 1 others more... |
| Homologous interactions | 6 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
