HitPredict

Interactor 1: TOP2B (Q02880)
DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme)
Gene: TOP2B

Interactor 2: H3C (Q6NXT2)
Histone H3.3C (Histone H3.5)
Gene: H3-5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37071682
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1626 Hs			1 135
+	Hs
		998231 TOP2B_HUMAN (1-1626): 0: 1794: 100.00		H31_HUMAN (1-135): 5.13e-58: 177: 92.65
+	Hs
		1016788 TOP2B_HUMAN (1-1626): 0: 1794: 100.00		H33_HUMAN (1-135): 2.2e-57: 176: 94.85
+	Hs
		883510 TOP2B_HUMAN (1-1626): 0: 1794: 100.00		CENPA_HUMAN (9-132): 1.1e-45: 146: 47.69
+	Hs
		542451 TOP2A_HUMAN (33-1617): 0: 1627: 66.50		H31_HUMAN (1-135): 5.13e-58: 177: 92.65
+	Hs
		542461 TOP2A_HUMAN (33-1617): 0: 1627: 66.50		H33_HUMAN (1-135): 2.2e-57: 176: 94.85
+	Hs
		542534 TOP2A_HUMAN (33-1617): 0: 1627: 66.50		H31T_HUMAN (1-135): 2.71e-57: 176: 89.71
+	Hs
		542555 TOP2A_HUMAN (33-1617): 0: 1627: 66.50		H32_HUMAN (1-135): 8.76e-57: 174: 93.38
+	Hs
		542383 TOP2A_HUMAN (33-1617): 0: 1627: 66.50		CENPA_HUMAN (9-132): 1.1e-45: 146: 47.69
+	Sc
		448995 TOP2_YEAST (44-1445): 0: 1262: 41.29		H3_YEAST (1-135): 5.88e-52: 162: 85.29
+	Sc
		448953 TOP2_YEAST (44-1445): 0: 1262: 41.29		CENPA_YEAST (8-133): 2.02e-45: 149: 54.26
+	Hs
		814781 CUX1_HUMAN (894-1593): 3.36e-40: 165: 11.84		H31_HUMAN (1-135): 5.13e-58: 177: 92.65
+	Hs
		814784 CUX1_HUMAN (894-1593): 3.36e-40: 165: 11.84		H33_HUMAN (1-135): 2.2e-57: 176: 94.85
+	Hs
		814766 CUX1_HUMAN (894-1593): 3.36e-40: 165: 11.84		CENPA_HUMAN (9-132): 1.1e-45: 146: 47.69