HitPredict

Interactor 1: TOP2A (P11388)
DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)
Gene: TOP2A

Interactor 2: H33 (P84243)
Histone H3.3
Gene: H3-3A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	36089195, 29044188, 20504901
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0032991 - protein-containing complex GO:0046982 - protein heterodimerization activity
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1531 Hs			1 136
+	Hs
		542451 TOP2A_HUMAN (1-1531): 0: 1754: 100.00		H31_HUMAN (1-136): 3.09e-60: 183: 96.32
+	Hs
		542534 TOP2A_HUMAN (1-1531): 0: 1754: 100.00		H31T_HUMAN (1-136): 2.59e-59: 181: 93.38
+	Hs
		542555 TOP2A_HUMAN (1-1531): 0: 1754: 100.00		H32_HUMAN (1-136): 5.34e-59: 180: 97.06
+	Hs
		542383 TOP2A_HUMAN (1-1531): 0: 1754: 100.00		CENPA_HUMAN (9-133): 2.43e-45: 146: 50.76
+	Hs
		998231 TOP2B_HUMAN (14-1523): 0: 1648: 65.78		H31_HUMAN (1-136): 3.09e-60: 183: 96.32
+	Hs
		1016788 TOP2B_HUMAN (14-1523): 0: 1648: 65.78		H33_HUMAN (1-136): 1.13e-59: 182: 100.00
+	Hs
		1039519 TOP2B_HUMAN (14-1523): 0: 1648: 65.78		H3C_HUMAN (1-136): 2e-56: 173: 95.59
+	Hs
		883510 TOP2B_HUMAN (14-1523): 0: 1648: 65.78		CENPA_HUMAN (9-133): 2.43e-45: 146: 50.76
+	Sc
		448995 TOP2_YEAST (24-1404): 0: 1259: 41.63		H3_YEAST (1-136): 3.63e-54: 168: 90.44
+	Sc
		448953 TOP2_YEAST (24-1404): 0: 1259: 41.63		CENPA_YEAST (41-134): 2.79e-31: 112: 67.01