HitPredict

Interactor 1: CREB5 (Q02930)
Cyclic AMP-responsive element-binding protein 5 (CREB-5) (cAMP-responsive element-binding protein 5) (cAMP-response element-binding protein A) (CRE-BPa)
Gene: CREB5

Interactor 2: Q6FG41 (Q6FG41)
Protein c-Fos (Cellular oncogene fos)
Gene: FOS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.80	0.594

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	bZIP_1~bZIP_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 508 Hs			1 380
+	Hs
		370636 CREB5_HUMAN (1-508): 1.01e-96: 303: 100.00		FOS_HUMAN (1-380): 1.69e-84: 263: 100.00
+	Mm
		370859 ATF7_MOUSE (10-456): 3.46e-71: 234: 35.94		FOS_MOUSE (1-380): 1.28e-84: 263: 93.68
+	Hs
		370546 ATF7_HUMAN (10-505): 1.24e-68: 229: 36.18		FOS_HUMAN (1-380): 1.69e-84: 263: 100.00
+	Hs
		1039816 CREB5_HUMAN (1-508): 1.01e-96: 303: 100.00		BACH2_HUMAN (14-307): 4.12e-34: 136: 13.65
+	Hs
		584012 CREB5_HUMAN (1-508): 1.01e-96: 303: 100.00		FOSL1_HUMAN (59-287): 1.44e-34: 130: 37.61
+	Hs
		166519 CREB5_HUMAN (1-508): 1.01e-96: 303: 100.00		BACH1_HUMAN (4-295): 1.69e-30: 125: 12.99
+	Hs
		605252 CREB5_HUMAN (1-508): 1.01e-96: 303: 100.00		ATF7_HUMAN (82-289): 7.94e-31: 124: 16.59
+	Hs
		584083 CREB5_HUMAN (1-508): 1.01e-96: 303: 100.00		FOSL2_HUMAN (2-380): 3.2e-31: 122: 39.54
+	Hs
		583538 CREB5_HUMAN (1-508): 1.01e-96: 303: 100.00		ATF2_HUMAN (4-283): 3.59e-29: 119: 18.57
+	Hs
		1039731 CREB5_HUMAN (1-508): 1.01e-96: 303: 100.00		CREB5_HUMAN (92-233): 1.13e-24: 107: 19.01
+	Hs
		1039825 CREB5_HUMAN (1-508): 1.01e-96: 303: 100.00		BATF3_HUMAN (120-228): 1.46e-27: 107: 27.52
+	Hs
		921037 CREB5_HUMAN (1-508): 1.01e-96: 303: 100.00		FOSB_HUMAN (2-380): 1.6e-25: 107: 34.24
+	Hs
		603641 CREB5_HUMAN (1-508): 1.01e-96: 303: 100.00		JUNB_HUMAN (85-215): 3.2e-25: 106: 19.86
+	Hs
		429757 CREB5_HUMAN (1-508): 1.01e-96: 303: 100.00		JUN_HUMAN (48-215): 1.19e-23: 102: 16.47
+	Hs
		1039788 CREB5_HUMAN (1-508): 1.01e-96: 303: 100.00		JDP2_HUMAN (147-220): 1.48e-21: 92: 37.84
+	Hs
		605073 CREB5_HUMAN (1-508): 1.01e-96: 303: 100.00		JUND_HUMAN (112-215): 1.8e-13: 72.8: 20.00
+	Hs
		583988 ATF7_HUMAN (10-505): 1.24e-68: 229: 36.18		FOSL1_HUMAN (59-287): 1.44e-34: 130: 37.61
+	Hs
		166494 ATF7_HUMAN (10-505): 1.24e-68: 229: 36.18		BACH1_HUMAN (4-295): 1.69e-30: 125: 12.99
+	Hs
		583438 ATF7_HUMAN (10-505): 1.24e-68: 229: 36.18		ATF2_HUMAN (4-283): 3.59e-29: 119: 18.57
+	Hs
		429262 ATF7_HUMAN (10-505): 1.24e-68: 229: 36.18		JUN_HUMAN (48-215): 1.19e-23: 102: 16.47