HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: DDX18 (Q9NVP1)
ATP-dependent RNA helicase DDX18 (EC 3.6.4.13) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb)
Gene: DDX18

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21182205
Identification Methods	affinity chromatography technology, cosedimentation through density gradient
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 670
+	Hs
		369523 ESR1_HUMAN (1-595): 0: 599: 100.00		DDX10_HUMAN (124-621): 9.53e-167: 501: 41.60
+	Hs
		370050 ESR1_HUMAN (1-595): 0: 599: 100.00		DDX55_HUMAN (176-668): 5.77e-136: 413: 34.05
+	Hs
		370142 ESR1_HUMAN (1-595): 0: 599: 100.00		DDX17_HUMAN (99-603): 5.5e-134: 412: 24.95
+	Hs
		368944 ESR1_HUMAN (1-595): 0: 599: 100.00		DDX5_HUMAN (71-600): 2.27e-133: 407: 22.47
+	Hs
		133828 ESR1_HUMAN (1-595): 0: 599: 100.00		DDX3X_HUMAN (17-564): 1.37e-130: 401: 22.59
+	Hs
		181675 ESR1_HUMAN (1-595): 0: 599: 100.00		DDX3Y_HUMAN (24-577): 1.9e-128: 396: 23.27
+	Hs
		1027916 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DDX10_HUMAN (124-621): 9.53e-167: 501: 41.60
+	Hs
		370457 ESR1_HUMAN (1-595): 0: 599: 100.00		DDX31_HUMAN (87-619): 1.02e-81: 278: 33.71
+	Hs
		1245858 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DDX55_HUMAN (176-668): 5.77e-136: 413: 34.05
+	Hs
		134142 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DDX3X_HUMAN (17-564): 1.37e-130: 401: 22.59
+	Hs
		370199 ESR1_HUMAN (1-595): 0: 599: 100.00		DDX27_HUMAN (121-574): 3.56e-56: 206: 34.88
+	Hs
		370841 ESR1_HUMAN (1-595): 0: 599: 100.00		DDX49_HUMAN (195-565): 1.87e-54: 195: 33.95
+	Hs
		133914 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		DDX3X_HUMAN (17-564): 1.37e-130: 401: 22.59
+	Hs
		181691 ERR3_HUMAN (91-547): 2.27e-116: 355: 33.77		DDX3Y_HUMAN (24-577): 1.9e-128: 396: 23.27
+	Hs
		571644 NR2E1_HUMAN (171-549): 5.7e-110: 336: 29.12		DDX5_HUMAN (71-600): 2.27e-133: 407: 22.47
+	Hs
		1269636 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DDX31_HUMAN (87-619): 1.02e-81: 278: 33.71
+	Hs
		1269573 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DDX47_HUMAN (192-524): 3.3e-64: 221: 39.82
+	Hs
		1270067 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DDX49_HUMAN (195-565): 1.87e-54: 195: 33.95
+	Hs
		377667 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		DDX47_HUMAN (192-524): 3.3e-64: 221: 39.82
+	Hs
		377588 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		DDX27_HUMAN (121-574): 3.56e-56: 206: 34.88