HitPredict

Interactor 1: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Interactor 2: FEM1C (Q96JP0)
Protein fem-1 homolog C (FEM1c) (FEM1-gamma)
Gene: FEM1C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	33961781, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0031462 - Cul2-RING ubiquitin ligase complex GO:0140627 - ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 617
+	Hs
		1041453 CUL2_HUMAN (1-745): 0: 840: 100.00		FEM1A_HUMAN (1-616): 1.28e-106: 337: 62.69
+	Hs
		1041494 CUL2_HUMAN (1-745): 0: 840: 100.00		FEM1B_HUMAN (7-616): 1.65e-105: 333: 37.32
+	Hs
		1043295 CUL4A_HUMAN (4-745): 0: 773: 26.86		FEM1B_HUMAN (7-616): 1.65e-105: 333: 37.32
+	Ce
		566262 CUL2_CAEEL (2-745): 0: 720: 42.27		FEM1_CAEEL (4-616): 8.68e-122: 376: 32.88
+	Hs
		1274017 CUL5_HUMAN (7-745): 0: 627: 26.69		FEM1C_HUMAN (1-617): 3.11e-125: 384: 100.00
+	Hs
		1274035 CUL5_HUMAN (7-745): 0: 627: 26.69		FEM1A_HUMAN (1-616): 1.28e-106: 337: 62.69
+	Hs
		1274077 CUL5_HUMAN (7-745): 0: 627: 26.69		FEM1B_HUMAN (7-616): 1.65e-105: 333: 37.32
+	Hs
		1021398 CUL4A_HUMAN (4-745): 0: 773: 26.86		ANK3_HUMAN (346-615): 4.61e-44: 172: 12.19
+	Hs
		1021397 CUL3_HUMAN (1-745): 0: 768: 26.38		ANK3_HUMAN (346-615): 4.61e-44: 172: 12.19
+	Hs
		1042054 CUL3_HUMAN (1-745): 0: 768: 26.38		ANR52_HUMAN (340-612): 8.62e-36: 145: 11.29
+	Hs
		1041441 CUL2_HUMAN (1-745): 0: 840: 100.00		ASB2_HUMAN (305-572): 1.16e-12: 72.8: 17.54
+	Hs
		556700 CUL3_HUMAN (1-745): 0: 768: 26.38		ANK1_HUMAN (363-615): 5.31e-33: 137: 9.46
+	Hs
		166925 CUL3_HUMAN (1-745): 0: 768: 26.38		ANR28_HUMAN (488-613): 4.05e-16: 84.4: 20.47
+	Hs
		1041153 CUL1_HUMAN (6-745): 0: 775: 36.24		ASB2_HUMAN (305-572): 1.16e-12: 72.8: 17.54
+	Hs
		1043172 CUL4A_HUMAN (4-745): 0: 773: 26.86		ASB2_HUMAN (305-572): 1.16e-12: 72.8: 17.54
+	Hs
		1274043 CUL5_HUMAN (7-745): 0: 627: 26.69		TNKS2_HUMAN (251-617): 1.65e-29: 126: 11.44
+	Hs
		1274023 CUL5_HUMAN (7-745): 0: 627: 26.69		ASB2_HUMAN (305-572): 1.16e-12: 72.8: 17.54