HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: WDR81 (Q562E7)
WD repeat-containing protein 81
Gene: WDR81

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 1941
+	Hs
		903207 CUL3_HUMAN (1-768): 0: 951: 100.00		WDR5_HUMAN (1473-1813): 5.03e-77: 261: 14.57
+	Hs
		1042655 CUL3_HUMAN (1-768): 0: 951: 100.00		NLE1_HUMAN (1294-1675): 1.19e-39: 157: 13.97
+	Hs
		1041872 CUL3_HUMAN (1-768): 0: 951: 100.00		WDFY4_HUMAN (1749-1940): 8.52e-22: 105: 14.90
+	Hs
		903208 CUL4A_HUMAN (10-768): 0: 791: 38.32		WDR5_HUMAN (1473-1813): 5.03e-77: 261: 14.57
+	Hs
		1043085 CUL4A_HUMAN (10-768): 0: 791: 38.32		WDR5B_HUMAN (1472-1813): 1.25e-75: 256: 13.28
+	Hs
		903209 CUL4B_HUMAN (5-768): 0: 779: 36.77		WDR5_HUMAN (1473-1813): 5.03e-77: 261: 14.57
+	Hs
		1043441 CUL4B_HUMAN (5-768): 0: 779: 36.77		WDR5B_HUMAN (1472-1813): 1.25e-75: 256: 13.28
+	Hs
		1042101 CUL3_HUMAN (1-768): 0: 951: 100.00		POC1B_HUMAN (1636-1911): 5.18e-12: 72.5: 20.60
+	Hs
		792982 CUL4A_HUMAN (10-768): 0: 791: 38.32		LIS1_HUMAN (1678-1939): 6.83e-54: 196: 13.94
+	Hs
		1043499 CUL4B_HUMAN (5-768): 0: 779: 36.77		FBXW7_HUMAN (1521-1850): 9.1e-54: 204: 16.62
+	Hs
		903206 CUL1_HUMAN (18-768): 0: 707: 30.57		WDR5_HUMAN (1473-1813): 5.03e-77: 261: 14.57
+	At
		95048 CUL4_ARATH (8-768): 0: 744: 38.61		KTN82_ARATH (1640-1904): 3.38e-57: 220: 22.96
+	Hs
		1043157 CUL4A_HUMAN (10-768): 0: 791: 38.32		SNR40_HUMAN (1772-1940): 2.98e-36: 144: 13.22
+	Hs
		1043509 CUL4B_HUMAN (5-768): 0: 779: 36.77		SNR40_HUMAN (1772-1940): 2.98e-36: 144: 13.22
+	Hs
		1041133 CUL1_HUMAN (18-768): 0: 707: 30.57		FBXW7_HUMAN (1521-1850): 9.1e-54: 204: 16.62
+	Hs
		841974 CUL4A_HUMAN (10-768): 0: 791: 38.32		LRBA_HUMAN (1642-1940): 3.21e-21: 104: 14.07
+	Hs
		1043114 CUL4A_HUMAN (10-768): 0: 791: 38.32		POC1B_HUMAN (1636-1911): 5.18e-12: 72.5: 20.60
+	Hs
		1043469 CUL4B_HUMAN (5-768): 0: 779: 36.77		POC1B_HUMAN (1636-1911): 5.18e-12: 72.5: 20.60
+	Mm
		1257398 CUL1_MOUSE (17-768): 0: 709: 30.53		FBXW7_MOUSE (1813-1940): 3.3e-25: 115: 13.18