Protein: HOME3
Homer protein homolog 3 (Homer-3)

Gene: HOME3, HOMER3
Organism: Homo sapiens
Interactions: 134
UniProt ID: Q9NSC5

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006605 - protein targeting
GO:0007216 - G protein-coupled glutamate receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1295218

HOME1
Homer protein homolog 1

7

15

High-throughput

0.973

High

1449314

HOME3
Homer protein homolog 3

4

15

High-throughput

0.893

High

1449299

HOME2
Homer protein homolog 2

2

16

High-throughput

0.811

High

1449319

ABI2
Abl interactor 2

6

20

High-throughput

0.741

High

1316711

ABI1
Abl interactor 1

5

20

High-throughput

0.721

High

1390727

DYL2
Dynein light chain 2, cytoplasmic

5

4

High-throughput

0.717

High

364183

MOS
Proto-oncogene serine/threonine-protein kinase mos

4

1

High-throughput

0.703

High

1157499

PKN1
Serine/threonine-protein kinase N1

4

5

High-throughput

0.703

High

895804

LHX2
LIM/homeobox protein Lhx2

2

5

High-throughput

0.700

High

1160772

DREB
Drebrin

4

8

High-throughput

0.697

High

1449321

ABI3
ABI gene family member 3

4

20

High-throughput

0.695

High

288522

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

3

6

High-throughput

0.675

High

681049

PSA1
Proteasome subunit alpha type-1

3

1

High-throughput

0.675

High

974061

RUXF
Small nuclear ribonucleoprotein F

3

1

High-throughput

0.675

High

1239747

PPR18
Phostensin

3

4

High-throughput

0.675

High

1381242

WBP2
WW domain-binding protein 2

3

1

Small-scale

0.672

High

1360093

PALLD
Palladin

3

9

High-throughput

0.665

High

321941

FRYL
Protein furry homolog-like

5

1

High-throughput

0.660

High

685361

PAX6
Paired box protein Pax-6

3

4

Small-scale

0.650

High

991729

DYL1
Dynein light chain 1, cytoplasmic

3

4

High-throughput

0.647

High

187809

EIF3D
Eukaryotic translation initiation factor 3 subunit D

3

0

High-throughput

0.646

High

219563

WIPF1
WAS/WASL-interacting protein family member 1

2

5

High-throughput

0.633

High

1449318

IFT57
Intraflagellar transport protein 57 homolog

4

2

High-throughput

0.630

High

1449316

FBX28
F-box only protein 28

4

1

High-throughput

0.629

High

1325320

PALS1
Protein PALS1

2

6

High-throughput

0.628

High

1341105

INADL
InaD-like protein

2

15

High-throughput

0.628

High

1390215

CYFP2
Cytoplasmic FMR1-interacting protein 2

2

3

High-throughput

0.628

High

1449329

NCKP1
Nck-associated protein 1

2

5

High-throughput

0.628

High

1449331

WASF2
Actin-binding protein WASF2

2

7

High-throughput

0.628

High

1392790

P121A
Nuclear envelope pore membrane protein POM 121

3

4

High-throughput

0.616

High

423279

A4
Amyloid-beta precursor protein

2

1

Small-scale

0.611

High

140455

SDCB1
Syntenin-1

2

14

High-throughput

0.606

High

478731

HXB5
Homeobox protein Hox-B5

2

10

High-throughput

0.606

High

893743

MEOX1
Homeobox protein MOX-1

2

10

High-throughput

0.606

High

1057663

CDK18
Cyclin-dependent kinase 18

2

3

High-throughput

0.606

High

1187574

AR13B
ADP-ribosylation factor-like protein 13B

2

5

High-throughput

0.606

High

1214246

KANK4
KN motif and ankyrin repeat domain-containing protein 4

2

8

High-throughput

0.606

High

1225086

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

11

High-throughput

0.606

High

1253291

CC141
Coiled-coil domain-containing protein 141

2

20

High-throughput

0.606

High

1330238

ZN655
Zinc finger protein 655

2

6

High-throughput

0.606

High

1336405

SLAI1
SLAIN motif-containing protein 1

2

1

High-throughput

0.606

High

1348530

LNX1
E3 ubiquitin-protein ligase LNX

2

15

High-throughput

0.606

High

1371453

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

13

High-throughput

0.606

High

1392930

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

1

High-throughput

0.606

High

1399762

RBM14
RNA-binding protein 14

2

1

High-throughput

0.606

High

1415793

SARG
Specifically androgen-regulated gene protein

2

1

High-throughput

0.606

High

1449317

RBM22
Pre-mRNA-splicing factor RBM22

2

2

High-throughput

0.606

High

1449320

ZBTB4
Zinc finger and BTB domain-containing protein 4

2

4

High-throughput

0.606

High

278978

PEX14
Peroxisomal membrane protein PEX14

2

0

High-throughput

0.602

High

488139

IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

2

0

High-throughput

0.602

High

1449323

DPOG2
DNA polymerase subunit gamma-2

2

0

High-throughput

0.602

High

353750

DRC4
Dynein regulatory complex subunit 4

2

0

High-throughput

0.580

High

1081493

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

1158568

CDC37
Hsp90 co-chaperone Cdc37

2

0

High-throughput

0.580

High

1187930

KR197
Keratin-associated protein 19-7

2

0

High-throughput

0.580

High

1279468

SAXO4
Stabilizer of axonemal microtubules 4

2

0

High-throughput

0.580

High

1349296

MDM1
Nuclear protein MDM1

2

0

High-throughput

0.580

High

1396203

PLAT5
Phospholipase A and acyltransferase 5

2

0

High-throughput

0.580

High

1276166

NUP54
Nucleoporin p54

2

2

High-throughput

0.574

High

1358672

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

2

5

High-throughput

0.574

High

397031

ESR1
Estrogen receptor

2

16

High-throughput

0.571

High

641346

RYR1
Ryanodine receptor 1

1

5

Small-scale

0.561

High

878238

TRPC1
Short transient receptor potential channel 1

1

4

Small-scale

0.561

High

246982

KDM1A
Lysine-specific histone demethylase 1A

2

2

High-throughput

0.553

High

567194

ZNF35
Zinc finger protein 35

2

5

High-throughput

0.553

High

600074

ZNF19
Zinc finger protein 19

2

5

High-throughput

0.553

High

662286

PAX7
Paired box protein Pax-7

2

2

High-throughput

0.553

High

733274

OTX2
Homeobox protein OTX2

2

5

High-throughput

0.553

High

935636

MFAP1
Microfibrillar-associated protein 1

2

5

High-throughput

0.553

High

1180505

C19L2
CWF19-like protein 2

2

1

High-throughput

0.553

High

1206156

TGO1
Transport and Golgi organization protein 1 homolog

2

9

High-throughput

0.553

High

1289083

GGN
Gametogenetin

2

3

High-throughput

0.553

High

1295115

F90A1
Protein FAM90A1

2

2

High-throughput

0.553

High

1392998

CC120
Coiled-coil domain-containing protein 120

2

2

High-throughput

0.553

High

1394348

ZN414
Zinc finger protein 414

2

2

High-throughput

0.553

High

1398648

F161B
Protein FAM161B

2

2

High-throughput

0.553

High

1399147

TOX2
TOX high mobility group box family member 2

2

2

High-throughput

0.553

High

1416181

SCNM1
Sodium channel modifier 1

2

2

High-throughput

0.553

High

1449315

TB22B
TBC1 domain family member 22B

2

3

High-throughput

0.553

High

1449324

PS1C2
Psoriasis susceptibility 1 candidate gene 2 protein

2

1

High-throughput

0.553

High

1449327

POLI
DNA polymerase iota

2

1

High-throughput

0.553

High

167979

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

8

Small-scale

0.552

High

969070

PRS8
26S proteasome regulatory subunit 8

1

3

Small-scale

0.552

High

1352989

CE192
Centrosomal protein of 192 kDa

2

2

High-throughput

0.552

High

1006743

SRPK2
SRSF protein kinase 2

1

4

High-throughput

0.550

High

564430

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.541

High

900189

FXR1
RNA-binding protein FXR1

1

11

High-throughput

0.541

High

900532

FXR2
RNA-binding protein FXR2

1

11

High-throughput

0.541

High

1056995

FMR1
Fragile X messenger ribonucleoprotein 1

1

11

High-throughput

0.541

High

1365007

TSC1
Hamartin

1

20

High-throughput

0.541

High

1417967

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

20

High-throughput

0.541

High

1127606

FAT1
Protocadherin Fat 1

1

5

Small-scale

0.536

High

414702

P53
Cellular tumor antigen p53

1

3

High-throughput

0.536

High

714450

PML
Protein PML

1

6

High-throughput

0.536

High

1049825

1433F
14-3-3 protein eta

1

20

High-throughput

0.536

High

1234760

SPOPL
Speckle-type POZ protein-like

1

7

High-throughput

0.536

High

1287171

MYPN
Myopalladin

1

8

High-throughput

0.536

High

1439172

Q9HCK3
KIAA1569 protein

2

2

High-throughput

0.533

High

302210

NEBL
Nebulette

1

20

High-throughput

0.523

High

1207394

EFHC1
EF-hand domain-containing protein 1

1

1

High-throughput

0.523

High

252178

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.513

High

1367748

PRCC
Proline-rich protein PRCC

1

1

High-throughput

0.494

High

1434978

SOX17
Transcription factor SOX-17

1

3

High-throughput

0.489

High

681232

PSA2
Proteasome subunit alpha type-2

1

3

High-throughput

0.481

High

791762

SYUA
Alpha-synuclein

1

2

High-throughput

0.481

High

1399278

LRRC7
Leucine-rich repeat-containing protein 7

1

3

High-throughput

0.481

High

243059

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.479

High

404462

GCR
Glucocorticoid receptor

1

16

High-throughput

0.479

High

607148

CEBPB
CCAAT/enhancer-binding protein beta

1

5

Small-scale

0.479

High

1255724

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.479

High

1333345

NHLC2
NHL repeat-containing protein 2

1

3

High-throughput

0.479

High

1449322

TRPC4
Short transient receptor potential channel 4

1

4

Small-scale

0.479

High

1449326

TRPC5
Short transient receptor potential channel 5

1

4

Small-scale

0.479

High

1449330

NINL
Ninein-like protein

1

11

High-throughput

0.479

High

50953

A1L1C6
LRRC7 protein

1

18

High-throughput

0.470

High

239219

ZNRD2
Protein ZNRD2

1

2

High-throughput

0.445

High

391486

FRIL
Ferritin light chain

1

3

High-throughput

0.445

High

730281

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.445

High

1150491

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

12

High-throughput

0.445

High

3259

A0A0S2Z470
Papillary renal cell carcinoma isoform 3

1

1

High-throughput

0.417

High

1258591

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

3

High-throughput

0.407

High

1449325

PNMA2
Paraneoplastic antigen Ma2

1

2

High-throughput

0.407

High

1449328

BCS1
Mitochondrial chaperone BCS1

1

8

High-throughput

0.407

High

887254

CEBPA
CCAAT/enhancer-binding protein alpha

1

5

High-throughput

0.373

High

1055281

MTG8
Protein CBFA2T1

4

0

High-throughput

0.367

High

1394896

EAF1
ELL-associated factor 1

4

0

High-throughput

0.367

High

391806

SMR3B
Submaxillary gland androgen-regulated protein 3B

2

0

High-throughput

0.316

High

506773

PRR35
Proline-rich protein 35

2

0

High-throughput

0.316

High

1196936

MSS51
Putative protein MSS51 homolog, mitochondrial

2

0

High-throughput

0.316

High

1198885

CD017
Uncharacterized protein C4orf17

2

0

High-throughput

0.316

High

1309211

Q8IVT4
Hypothetical MGC50722

2

0

High-throughput

0.316

High

1315747

SAXO1
Stabilizer of axonemal microtubules 1

2

0

High-throughput

0.316

High

1416472

LS14B
Protein LSM14 homolog B

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025