HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: SYLC (Q9P2J5)
Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) (cLRS)
Gene: LARS1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26949739, 35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0071230 - cellular response to amino acid stimulus GO:1904263 - positive regulation of TORC1 signaling
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 1176
+	Hs
		783027 CUL3_HUMAN (1-768): 0: 951: 100.00		SYIC_HUMAN (5-1136): 0: 692: 15.44
+	Hs
		643860 CUL3_HUMAN (1-768): 0: 951: 100.00		SYVC_HUMAN (7-1048): 0: 690: 14.45
+	Hs
		1042633 CUL3_HUMAN (1-768): 0: 951: 100.00		SYIM_HUMAN (4-959): 0: 568: 14.99
+	Hs
		783028 CUL4A_HUMAN (10-768): 0: 791: 38.32		SYIC_HUMAN (5-1136): 0: 692: 15.44