HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: RBX2 (Q9UBF6)
RING-box protein 2 (Rbx2) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein)
Gene: RNF7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.854

Property	Details
Experiments	19250909, 10230407, 33961781
Identification Methods	enzymatic study, two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Cullin~zf-rbx1, Cullin_Nedd8~zf-rbx1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 759 Hs			1 113
+	Mm
		921499 CUL4A_MOUSE (1-759): 0: 977: 95.13		RBX1_MOUSE (18-112): 5.7e-38: 125: 46.94
+	Mm
		1111822 CUL4A_MOUSE (1-759): 0: 977: 95.13		RBX2_MOUSE (1-113): 2.07e-33: 114: 96.46
+	Hs
		921254 CUL4A_HUMAN (1-759): 0: 963: 100.00		RBX1_HUMAN (18-112): 5.7e-38: 125: 46.94
+	Mm
		56790 CUL4B_MOUSE (10-759): 0: 927: 82.18		RBX1_MOUSE (18-112): 5.7e-38: 125: 46.94
+	Hs
		921255 CUL4B_HUMAN (10-759): 0: 927: 82.31		RBX1_HUMAN (18-112): 5.7e-38: 125: 46.94
+	Hs
		1043627 CUL4B_HUMAN (10-759): 0: 927: 82.31		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Hs
		1043443 CUL4B_HUMAN (10-759): 0: 927: 82.31		DZIP3_HUMAN (4-103): 1.17e-23: 96: 20.76
+	Dm
		1124381 Q5BI50_DROME (27-759): 0: 877: 65.90		RBX1A_DROME (12-112): 9.54e-38: 124: 45.19
+	At
		1228140 CUL4_ARATH (24-759): 0: 861: 57.40		RBX1A_ARATH (3-112): 2.07e-36: 121: 42.48
+	At
		1275966 CUL3A_ARATH (36-759): 0: 853: 38.26		RBX1A_ARATH (3-112): 2.07e-36: 121: 42.48
+	At
		1275962 CUL3B_ARATH (36-759): 0: 841: 37.99		RBX1A_ARATH (3-112): 2.07e-36: 121: 42.48
+	Hs
		921253 CUL3_HUMAN (32-759): 0: 814: 38.23		RBX1_HUMAN (18-112): 5.7e-38: 125: 46.94
+	Hs
		1042735 CUL3_HUMAN (32-759): 0: 814: 38.23		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Dm
		1213855 Q8IP45_DROME (51-759): 0: 776: 36.20		RBX1A_DROME (12-112): 9.54e-38: 124: 45.19
+	Dm
		1213836 Q8IP45_DROME (51-759): 0: 776: 36.20		RBX1B_DROME (12-113): 2.55e-35: 119: 43.27
+	Hs
		1042654 CUL3_HUMAN (32-759): 0: 814: 38.23		RNF12_HUMAN (49-104): 2.17e-10: 57.9: 23.21
+	Hs
		921251 CUL1_HUMAN (59-759): 0: 745: 30.55		RBX1_HUMAN (18-112): 5.7e-38: 125: 46.94
+	Mm
		921509 CUL1_MOUSE (59-759): 0: 745: 30.55		RBX1_MOUSE (18-112): 5.7e-38: 125: 46.94
+	Hs
		1041242 CUL1_HUMAN (59-759): 0: 745: 30.55		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Hs
		1041079 CUL1_HUMAN (59-759): 0: 745: 30.55		DZIP3_HUMAN (4-103): 1.17e-23: 96: 20.76