Protein: PUF6
Pumilio homology domain family member 6

Gene: PUF6
Organism: Saccharomyces cerevisiae S288C
Interactions: 193
UniProt ID: Q04373

Gene Ontology (top 5):
GO:0000900 - mRNA regulatory element binding translation repressor activity
GO:0003729 - mRNA binding
GO:0003730 - mRNA 3'-UTR binding
GO:0005634 - nucleus
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1046508

PUF6
Pumilio homology domain family member 6

2

5

High-throughput

0.776

High

804658

SSF1
Ribosome biogenesis protein SSF1

8

3

Small-scale

0.742

High

1046546

IF6
Eukaryotic translation initiation factor 6

6

1

Small-scale

0.736

High

803930

CIC1
Proteasome-interacting protein CIC1

6

1

Small-scale

0.724

High

830178

NOP2
25S rRNA

5

2

Small-scale

0.709

High

682375

SPB4
ATP-dependent rRNA helicase SPB4

5

8

High-throughput

0.709

High

816899

NUG1
Nuclear GTP-binding protein NUG1

5

2

Small-scale

0.706

High

1039626

NOG1
Nucleolar GTP-binding protein 1

5

1

Small-scale

0.706

High

1046534

YTM1
Ribosome biogenesis protein YTM1

5

4

Small-scale

0.706

High

1046543

DBP10
ATP-dependent RNA helicase DBP10

5

10

Small-scale

0.706

High

917555

NSA1
Ribosome biogenesis protein NSA1

6

0

Small-scale

0.695

High

924328

NOP13
Nucleolar protein 13

4

10

Small-scale

0.691

High

793527

MAK5
ATP-dependent RNA helicase MAK5

4

6

Small-scale

0.687

High

1043275

HAS1
ATP-dependent RNA helicase HAS1

4

7

High-throughput

0.686

High

1046529

BRX1
Ribosome biogenesis protein BRX1

4

7

Small-scale

0.686

High

850014

LOC1
60S ribosomal subunit assembly/export protein LOC1

4

0

Small-scale

0.673

High

751479

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

3

1

High-throughput

0.667

High

780560

SHE2
SWI5-dependent HO expression protein 2

4

0

Small-scale

0.664

High

782442

RPF2
Ribosome biogenesis protein RPF2

4

0

High-throughput

0.658

High

791105

NOP4
Nucleolar protein 4

3

8

Small-scale

0.657

High

827602

RLP7
Ribosome biogenesis protein RLP7

3

2

High-throughput

0.656

High

1046510

ERB1
Ribosome biogenesis protein ERB1

3

2

Small-scale

0.650

High

1046522

NOC4
Nucleolar complex protein 4

3

2

Small-scale

0.650

High

805089

RPF1
Ribosome production factor 1

4

0

Small-scale

0.649

High

918985

PESC
Pescadillo homolog

4

0

Small-scale

0.643

High

381627

H2B2
Histone H2B.2

3

1

High-throughput

0.643

High

814379

NOC2
Nucleolar complex protein 2

3

0

Small-scale

0.613

High

410330

RL25
Large ribosomal subunit protein uL23

2

1

High-throughput

0.611

High

746670

DRS1
ATP-dependent RNA helicase DRS1

2

7

High-throughput

0.611

High

1046515

FKBP4
FK506-binding protein 4

2

3

High-throughput

0.611

High

1044898

RRP17
Ribosomal RNA-processing protein 17

3

0

Small-scale

0.606

High

885083

RL4B
Large ribosomal subunit protein uL4B

2

1

Small-scale

0.601

High

1046511

RRP5
rRNA biogenesis protein RRP5

2

2

Small-scale

0.601

High

1046516

JIP5
WD repeat-containing protein JIP5

2

1

High-throughput

0.601

High

570138

RL3
Large ribosomal subunit protein uL3

3

1

Small-scale

0.593

High

518125

SSBP1
Single-stranded nucleic acid-binding protein

2

11

Small-scale

0.588

High

1046533

NIP7
60S ribosome subunit biogenesis protein NIP7

2

0

High-throughput

0.585

High

812116

DHH1
ATP-dependent RNA helicase DHH1

2

10

Small-scale

0.584

High

844603

UTP10
U3 small nucleolar RNA-associated protein 10

2

1

High-throughput

0.584

High

924842

NOP15
Ribosome biogenesis protein 15

2

9

Small-scale

0.584

High

1046527

RLP24
Ribosome biogenesis protein RLP24

2

1

Small-scale

0.584

High

1046536

NOP53
Ribosome biogenesis protein NOP53

2

1

High-throughput

0.584

High

758252

URB1
Nucleolar pre-ribosomal-associated protein 1

2

0

Small-scale

0.576

High

511487

RL43B
Large ribosomal subunit protein eL43B

2

1

Small-scale

0.575

High

534139

MAK16
Protein MAK16

2

1

Small-scale

0.571

High

633187

MAK11
Protein MAK11

2

3

Small-scale

0.571

High

671095

SIS1
Protein SIS1

2

1

High-throughput

0.571

High

763114

RRP1
Ribosomal RNA-processing protein 1

2

1

Small-scale

0.571

High

780315

EBP2
rRNA-processing protein EBP2

2

1

Small-scale

0.571

High

1046545

NOP58
Nucleolar protein 58

2

3

High-throughput

0.571

High

700289

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

2

0

High-throughput

0.563

High

858469

TAF1
Transcription initiation factor TFIID subunit 1

2

0

High-throughput

0.563

High

513409

RL23B
Large ribosomal subunit protein uL14B

2

0

Small-scale

0.559

High

798303

ENP1
Essential nuclear protein 1

2

0

High-throughput

0.559

High

1046521

RRP15
Ribosomal RNA-processing protein 15

2

0

Small-scale

0.559

High

525077

HSP71
Heat shock protein SSA1

2

10

High-throughput

0.552

High

527619

HSP72
Heat shock protein SSA2

2

10

High-throughput

0.552

High

780706

RRP14
Ribosomal RNA-processing protein 14

2

0

Small-scale

0.547

High

806655

RIX1
Pre-rRNA-processing protein RIX1

2

0

Small-scale

0.547

High

816793

NOP16
Nucleolar protein 16

2

0

Small-scale

0.547

High

818272

NSA2
Ribosome biogenesis protein NSA2

2

0

Small-scale

0.547

High

586015

CSK21
Casein kinase II subunit alpha

1

8

High-throughput

0.536

High

684838

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.536

High

793992

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

3

High-throughput

0.536

High

816177

DPO5
rDNA transcriptional regulator POL5

1

1

High-throughput

0.536

High

923122

BRE5
UBP3-associated protein BRE5

1

3

High-throughput

0.536

High

932181

RL15B
Large ribosomal subunit protein eL15B

1

1

High-throughput

0.536

High

1030571

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

High-throughput

0.536

High

1042365

GCN5
Histone acetyltransferase GCN5

1

4

High-throughput

0.536

High

1046517

DBP9
ATP-dependent RNA helicase DBP9

1

9

High-throughput

0.536

High

1046542

RL7B
Large ribosomal subunit protein uL30B

1

2

High-throughput

0.536

High

585366

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

High-throughput

0.515

High

449429

SPT2
Protein SPT2

1

0

High-throughput

0.513

High

603105

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.513

High

924029

ELOA1
Elongin-A

1

0

High-throughput

0.513

High

1046524

NOP6
Nucleolar protein 6

1

0

High-throughput

0.513

High

1046525

RIX7
Ribosome biogenesis ATPase RIX7

1

0

High-throughput

0.513

High

1046528

BUD20
Bud site selection protein 20

1

0

High-throughput

0.513

High

1046547

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.513

High

623009

CSK22
Casein kinase II subunit alpha'

1

6

Small-scale

0.501

High

809410

STM1
Suppressor protein STM1

1

0

High-throughput

0.493

High

712666

RL8B
Large ribosomal subunit protein eL8B

1

2

High-throughput

0.489

High

797221

SHE3
SWI5-dependent HO expression protein 3

1

0

Small-scale

0.479

High

381251

H2B1
Histone H2B.1

1

1

High-throughput

0.479

High

409783

RL24A
Large ribosomal subunit protein eL24A

1

1

High-throughput

0.479

High

419865

H2A2
Histone H2A.2

1

1

High-throughput

0.479

High

430920

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

6

Small-scale

0.479

High

433839

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.479

High

442102

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

503434

RL11A
Large ribosomal subunit protein uL5A

1

2

High-throughput

0.479

High

512640

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

513770

RL2A
Large ribosomal subunit protein uL2A

1

1

High-throughput

0.479

High

558862

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.479

High

580031

HSC82
ATP-dependent molecular chaperone HSC82

1

4

High-throughput

0.479

High

677239

SPB1
27S pre-rRNA

1

1

High-throughput

0.479

High

677554

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.479

High

689132

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.479

High

694637

SPT5
Transcription elongation factor SPT5

1

1

High-throughput

0.479

High

708116

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.479

High

750144

MRT4
Ribosome assembly factor MRT4

1

3

High-throughput

0.479

High

792235

GBLP
Small ribosomal subunit protein RACK1

1

4

High-throughput

0.479

High

802378

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

807141

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

3

High-throughput

0.479

High

826812

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.479

High

923200

NOG2
Nucleolar GTP-binding protein 2

1

2

Small-scale

0.479

High

923874

GIS2
Zinc finger protein GIS2

1

3

High-throughput

0.479

High

925036

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.479

High

925446

RCM1
25S rRNA

1

2

High-throughput

0.479

High

963705

H3
Histone H3

1

6

High-throughput

0.479

High

1031047

NOP3
Serine/arginine

1

12

Small-scale

0.479

High

1038748

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.479

High

1046115

RRB1
Ribosome assembly protein RRB1

1

2

High-throughput

0.479

High

1046514

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

3

High-throughput

0.479

High

1046526

NOC3
Nucleolar complex-associated protein 3

1

1

High-throughput

0.479

High

1046530

SGO1
Shugoshin

1

1

High-throughput

0.479

High

1046532

RRS1
Regulator of ribosome biosynthesis

1

1

High-throughput

0.479

High

1046539

YRA1
RNA annealing protein YRA1

1

7

High-throughput

0.479

High

1046541

RIO1
Serine/threonine-protein kinase RIO1

1

5

High-throughput

0.479

High

1046544

NOP56
Nucleolar protein 56

1

3

Small-scale

0.479

High

149947

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

435349

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

436164

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

449005

TOP2
DNA topoisomerase 2

1

0

High-throughput

0.458

High

594559

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

672942

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

674829

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

677963

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.458

High

689650

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

734728

IMB3
Importin subunit beta-3

1

0

Small-scale

0.458

High

735152

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

745868

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

795843

YBC8
UPF0642 protein YBL028C

1

0

High-throughput

0.458

High

797285

BMT2
25S rRNA

1

0

High-throughput

0.458

High

826075

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.458

High

918450

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.458

High

1044218

ARX1
Probable metalloprotease ARX1

1

0

Small-scale

0.458

High

1046022

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.458

High

1046509

UTP14
U3 small nucleolar RNA-associated protein 14

1

0

High-throughput

0.458

High

1046518

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

1046519

ESF1
Pre-rRNA-processing protein ESF1

1

0

Small-scale

0.458

High

1046537

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

382327

H4
Histone H4

1

1

High-throughput

0.445

High

393296

HSP82
ATP-dependent molecular chaperone HSP82

1

4

High-throughput

0.445

High

394885

EF1A
Elongation factor 1-alpha

1

5

High-throughput

0.445

High

427438

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.445

High

510795

HSP77
Import motor subunit, mitochondrial

1

4

High-throughput

0.445

High

546191

SSB1
Ribosome-associated molecular chaperone SSB1

1

10

High-throughput

0.445

High

676329

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.445

High

727301

HS104
Heat shock protein 104

1

3

High-throughput

0.445

High

739461

ZUO1
Zuotin

1

3

High-throughput

0.445

High

742349

HSP7F
Heat shock protein homolog SSE1

1

14

High-throughput

0.445

High

752702

HSP78
Heat shock protein 78, mitochondrial

1

4

High-throughput

0.445

High

755171

GCN1
eIF-2-alpha kinase activator GCN1

1

3

High-throughput

0.445

High

811388

CAJ1
Protein CAJ1

1

1

High-throughput

0.445

High

819733

SSB2
Ribosome-associated molecular chaperone SSB2

1

10

High-throughput

0.445

High

924059

JJJ1
J protein JJJ1

1

1

High-throughput

0.445

High

1025174

SEN1
Helicase SEN1

1

5

Small-scale

0.445

High

1046538

SSF2
Ribosome biogenesis protein SSF2

1

3

Small-scale

0.445

High

1046540

MAK21
Ribosome biogenesis protein MAK21

1

2

Small-scale

0.445

High

924725

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.438

High

503847

RL27A
Large ribosomal subunit protein eL27A

1

1

High-throughput

0.437

High

504406

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.437

High

504557

RL31B
Large ribosomal subunit protein eL31B

1

2

Small-scale

0.437

High

511287

RL20B
Large ribosomal subunit protein eL20B

1

1

High-throughput

0.437

High

513209

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

513573

RL1A
Large ribosomal subunit protein uL1A

1

4

High-throughput

0.437

High

601126

RL8A
Large ribosomal subunit protein eL8A

1

2

Small-scale

0.437

High

747569

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

753577

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

812634

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

1046523

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

590716

HSP26
Heat shock protein 26

1

0

High-throughput

0.426

High

626879

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.426

High

1046512

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.426

High

453783

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.407

High

816391

HSP7E
Heat shock protein SSC3, mitochondrial

1

4

High-throughput

0.407

High

1046513

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

14

High-throughput

0.407

High

814037

IF2P
Eukaryotic translation initiation factor 5B

3

0

Small-scale

0.353

High

383193

RLA4
Large ribosomal subunit protein P2B

1

0

High-throughput

0.279

Low

383887

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

455250

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

503231

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

514827

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

778522

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

874517

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

917367

YGO0
Uncharacterized membrane protein YGL140C

1

0

High-throughput

0.249

Low

1033553

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

1043916

BUL2
Ubiquitin ligase-binding protein BUL2

1

0

Small-scale

0.249

Low

1046295

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.249

Low

1046520

MAG2
E3 ubiquitin-protein ligase MAG2

1

0

High-throughput

0.249

Low

1046531

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

1046535

IOC2
ISWI one complex protein 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025