HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: CSN7A (Q9UBW8)
COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a)
Gene: COPS7A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.743

Property	Details
Experiments	31973889, 16964240, 17079684, 18606781, 21145461, 19295130, 26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 759 Hs			1 275
+	Hs
		1043232 CUL4A_HUMAN (1-759): 0: 963: 100.00		CSN7B_HUMAN (1-267): 2.01e-87: 262: 57.68
+	Hs
		1043630 CUL4B_HUMAN (10-759): 0: 927: 82.31		CSN7A_HUMAN (1-275): 4.23e-101: 298: 100.00
+	Hs
		1043598 CUL4B_HUMAN (10-759): 0: 927: 82.31		CSN7B_HUMAN (1-267): 2.01e-87: 262: 57.68
+	Hs
		1042750 CUL3_HUMAN (32-759): 0: 814: 38.23		CSN7A_HUMAN (1-275): 4.23e-101: 298: 100.00
+	Hs
		1042568 CUL3_HUMAN (32-759): 0: 814: 38.23		CSN7B_HUMAN (1-267): 2.01e-87: 262: 57.68
+	Hs
		1041247 CUL1_HUMAN (59-759): 0: 745: 30.55		CSN7A_HUMAN (1-275): 4.23e-101: 298: 100.00
+	Hs
		1041487 CUL2_HUMAN (51-759): 0: 710: 27.00		CSN7A_HUMAN (1-275): 4.23e-101: 298: 100.00
+	Hs
		1041205 CUL1_HUMAN (59-759): 0: 745: 30.55		CSN7B_HUMAN (1-267): 2.01e-87: 262: 57.68
+	Hs
		1041468 CUL2_HUMAN (51-759): 0: 710: 27.00		CSN7B_HUMAN (1-267): 2.01e-87: 262: 57.68
+	Ce
		1088884 CUL3_CAEEL (35-759): 0: 740: 33.72		EIF3M_CAEEL (1-198): 1.15e-48: 167: 17.96
+	Hs
		1274073 CUL5_HUMAN (59-759): 0: 589: 24.94		CSN7A_HUMAN (1-275): 4.23e-101: 298: 100.00
+	Hs
		1274053 CUL5_HUMAN (59-759): 0: 589: 24.94		CSN7B_HUMAN (1-267): 2.01e-87: 262: 57.68