HitPredict

Interactor 1: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Interactor 2: SHAN1 (Q9Y566)
SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP)
Gene: SHANK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	11509555
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ank_2~EF-hand_7, Ank_2~SH3_1, SH3_1~SH3_2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2472 Hs			1 2161
+	Mm
		82740 B9EKJ1_MOUSE (1-2472): 0: 706: 98.18		ANK3_MOUSE (62-643): 6.5e-76: 283: 14.17
+	Hs
		862037 SPTN1_HUMAN (1-2472): 0: 714: 100.00		DAPK1_HUMAN (221-642): 6.21e-61: 233: 13.90
+	Hs
		1021399 SPTN1_HUMAN (1-2472): 0: 714: 100.00		ANK3_HUMAN (45-689): 6.7e-57: 222: 13.24
+	Mm
		561160 SPTN1_MOUSE (1-2472): 0: 712: 98.42		SHAN3_MOUSE (297-1863): 1.13e-19: 99.3: 12.14
+	Rn
		555260 SPTN1_RAT (1-2472): 0: 713: 98.58		SHAN3_RAT (297-1863): 8.52e-19: 96.2: 12.70
+	Hs
		1045505 SPTN1_HUMAN (1-2472): 0: 714: 100.00		SHAN3_HUMAN (297-1867): 3.06e-18: 94.3: 12.50
+	Mm
		82760 B9EKJ1_MOUSE (1-2472): 0: 706: 98.18		SHAN3_MOUSE (297-1863): 1.13e-19: 99.3: 12.14
+	Mm
		561172 SPTN1_MOUSE (1-2472): 0: 712: 98.42		ANK2_MOUSE (552-2139): 1.16e-15: 85.9: 9.47
+	Hs
		360612 SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81		ANK1_HUMAN (169-613): 1.13e-62: 240: 15.68
+	Hs
		965102 SPTN1_HUMAN (1-2472): 0: 714: 100.00		ANK2_HUMAN (1281-2137): 1.65e-09: 65.9: 8.29
+	Hs
		164586 SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41		DAPK1_HUMAN (221-642): 6.21e-61: 233: 13.90
+	Hs
		164611 SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41		ANK3_HUMAN (45-689): 6.7e-57: 222: 13.24
+	Mm
		103598 Q3UGX2_MOUSE (2-1625): 2.78e-45: 183: 19.60		ANK3_MOUSE (62-643): 6.5e-76: 283: 14.17
+	Hs
		556695 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		ANK1_HUMAN (169-613): 1.13e-62: 240: 15.68
+	Hs
		862027 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		DAPK1_HUMAN (221-642): 6.21e-61: 233: 13.90
+	Hs
		963306 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		ANK3_HUMAN (45-689): 6.7e-57: 222: 13.24
+	Mm
		1115949 Q68FG2_MOUSE (141-1932): 3.76e-63: 242: 20.06		SHAN3_MOUSE (297-1863): 1.13e-19: 99.3: 12.14
+	Dr
		1186355 Q7SYE2_DANRE (1980-2470): 8.61e-74: 268: 33.47		MIB1_DANRE (184-388): 5.4e-11: 70.5: 27.27
+	Hs
		164604 SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41		ANK2_HUMAN (1281-2137): 1.65e-09: 65.9: 8.29
+	Hs
		963292 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		ANK2_HUMAN (1281-2137): 1.65e-09: 65.9: 8.29