Interactor 1: RUNX2 (Q13950)
Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit)
Gene: RUNX2

Interactor 2: PEBB (Q13951)
Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit)
Gene: CBFB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.84 1.00 0.922

The method score is based on:

Property Details
Experiments 23333304, 28500134, 31253590, 33961781, 34591612
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains CBF_beta~Runt
Common GO terms GO:0001649 - osteoblast differentiation
GO:0005654 - nucleoplasm
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0045944 - positive regulation of transcription by RNA polymerase II
GO:0048469 - cell maturation
Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 521
Hs

1 182
+ Rn
+ Mm
+ Mm
+ Hs
+ Hs
+ Dm
+ Dm
+ Dm

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Last updated: 15 Jul 2024