HitPredict

Interactor 1: KEAP1 (Q14145)
Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19)
Gene: KEAP1

Interactor 2: Q8N4I8 (Q8N4I8)
KLHL3 protein
Gene: KLHL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BACK~BTB, BTB~BTB
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 624 Hs			1 301
+	Hs
		1049352 KEAP1_HUMAN (1-624): 0: 584: 100.00		KLHL3_HUMAN (1-301): 3.39e-120: 358: 100.00
+	Hs
		307172 KEAP1_HUMAN (1-624): 0: 584: 100.00		KLHL2_HUMAN (3-301): 3.69e-113: 340: 70.00
+	Hs
		1049221 KEAP1_HUMAN (1-624): 0: 584: 100.00		KLH12_HUMAN (30-295): 8.92e-103: 313: 45.87
+	Hs
		1049238 KEAP1_HUMAN (1-624): 0: 584: 100.00		KLH24_HUMAN (30-298): 3.52e-98: 302: 40.15
+	Hs
		1377320 KLH20_HUMAN (17-610): 1.34e-179: 523: 37.13		KLH20_HUMAN (7-297): 3.32e-114: 343: 45.02
+	Hs
		1049204 KEAP1_HUMAN (1-624): 0: 584: 100.00		KEAP1_HUMAN (3-286): 3.33e-89: 279: 32.41
+	Hs
		152490 KEAP1_HUMAN (1-624): 0: 584: 100.00		ENC1_HUMAN (5-295): 3.48e-88: 276: 31.51
+	Mm
		1378292 KEAP1_MOUSE (1-624): 0: 579: 94.07		KEAP1_MOUSE (3-286): 4.26e-89: 279: 33.10
+	Hs
		1120830 KLH20_HUMAN (17-610): 1.34e-179: 523: 37.13		KLH12_HUMAN (30-295): 8.92e-103: 313: 45.87
+	Hs
		1164636 KLH20_HUMAN (17-610): 1.34e-179: 523: 37.13		KLH24_HUMAN (30-298): 3.52e-98: 302: 40.15
+	Hs
		307225 KLH13_HUMAN (3-609): 6.31e-164: 485: 25.48		KLHL2_HUMAN (3-301): 3.69e-113: 340: 70.00
+	Hs
		1377325 KLH20_HUMAN (17-610): 1.34e-179: 523: 37.13		IPP_HUMAN (14-295): 7.93e-93: 287: 32.75
+	Hs
		1121511 KLH20_HUMAN (17-610): 1.34e-179: 523: 37.13		KLH26_HUMAN (11-297): 1.33e-91: 285: 30.31
+	Hs
		1356007 KLH20_HUMAN (17-610): 1.34e-179: 523: 37.13		KLH21_HUMAN (19-299): 1.06e-89: 280: 32.62
+	Hs
		1120822 KLH13_HUMAN (3-609): 6.31e-164: 485: 25.48		KLH12_HUMAN (30-295): 8.92e-103: 313: 45.87
+	Hs
		1264856 KLHL6_HUMAN (7-611): 2.14e-166: 490: 22.35		KLHL6_HUMAN (3-294): 2.16e-94: 293: 36.51
+	Hs
		1221247 KLHL6_HUMAN (7-611): 2.14e-166: 490: 22.35		KLHL7_HUMAN (36-295): 8.07e-91: 282: 39.85
+	Hs
		1121502 KLH13_HUMAN (3-609): 6.31e-164: 485: 25.48		KLH26_HUMAN (11-297): 1.33e-91: 285: 30.31
+	Hs
		152500 KLH13_HUMAN (3-609): 6.31e-164: 485: 25.48		ENC1_HUMAN (5-295): 3.48e-88: 276: 31.51
+	Dr
		1092565 KEP1A_DANRE (23-613): 3.93e-171: 502: 52.79		KEP1A_DANRE (31-269): 5.71e-53: 184: 39.51