HitPredict

Interactor 1: GIT2 (Q14161)
ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)
Gene: GIT2

Interactor 2: RHOU (Q7L0Q8)
Rho-related GTP-binding protein RhoU (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1)
Gene: RHOU

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~Ras
Common GO terms	GO:0005925 - focal adhesion GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 759 Hs			1 258
+	Hs
		1050143 GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00		RHOV_HUMAN (49-258): 3.82e-87: 260: 60.66
+	Hs
		892368 GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		950990 GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00		RHOG_HUMAN (48-233): 5.28e-83: 248: 48.93
+	Hs
		925274 GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		545371 GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52
+	Hs
		894000 GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Hs
		564527 GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00		RHOQ_HUMAN (50-221): 2.69e-66: 206: 56.40
+	Hs
		1050152 GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00		RHOJ_HUMAN (40-238): 2.64e-63: 199: 51.26
+	Hs
		1296770 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		RHOV_HUMAN (49-258): 3.82e-87: 260: 60.66
+	Hs
		1183621 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		RHOU_HUMAN (1-258): 1.4e-83: 252: 100.00
+	Hs
		892692 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		951478 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		RHOG_HUMAN (48-233): 5.28e-83: 248: 48.93
+	Hs
		925751 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Gg
		1154344 Q9DG15_CHICK (1-758): 1.05e-140: 433: 64.96		Q6LC82_CHICK (50-234): 2.11e-79: 239: 56.76
+	Hs
		545710 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52
+	Hs
		894610 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Hs
		564752 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		RHOQ_HUMAN (50-221): 2.69e-66: 206: 56.40
+	Hs
		1331002 GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74		RHOJ_HUMAN (40-238): 2.64e-63: 199: 51.26
+	Dm
		185486 GIT_DROME (9-613): 6.41e-76: 261: 35.36		O18332_DROME (39-256): 1.05e-80: 242: 22.37
+	Mm
		892722 AGAP2_MOUSE (3-224): 1.24e-64: 236: 32.00		CDC42_MOUSE (50-236): 2.23e-74: 226: 58.82