HitPredict

Interactor 1: DSC3 (Q14574)
Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP)
Gene: DSC3

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 896 Hs			1 839
+	Hs
		508000 DSC3_HUMAN (1-896): 0: 847: 100.00		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		1055828 DSC3_HUMAN (1-896): 0: 847: 100.00		DDR2_HUMAN (527-824): 2.05e-70: 250: 43.30
+	Hs
		411386 DSC3_HUMAN (1-896): 0: 847: 100.00		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		435643 DSC3_HUMAN (1-896): 0: 847: 100.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		537741 DSC3_HUMAN (1-896): 0: 847: 100.00		INSRR_HUMAN (513-820): 1.33e-62: 231: 40.84
+	Hs
		580237 CADH2_HUMAN (2-385): 2.16e-54: 205: 17.55		NTRK3_HUMAN (1-839): 0: 671: 100.00
+	Hs
		435534 CADH3_HUMAN (10-891): 0: 577: 27.49		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		508295 PCDA8_HUMAN (2-470): 1.82e-86: 298: 16.16		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		385795 PCDB3_HUMAN (2-475): 2.75e-78: 272: 15.99		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		508294 PCDB7_HUMAN (2-485): 5.59e-82: 282: 17.26		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		384674 DSG1_HUMAN (130-573): 7.15e-68: 247: 32.29		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		384238 CADH2_HUMAN (2-385): 2.16e-54: 205: 17.55		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		507842 CADH2_HUMAN (2-385): 2.16e-54: 205: 17.55		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		434321 PCDGH_HUMAN (2-464): 7.18e-93: 315: 15.98		RET_HUMAN (282-837): 1.5e-108: 360: 25.76
+	Hs
		434134 CADH2_HUMAN (2-385): 2.16e-54: 205: 17.55		RET_HUMAN (282-837): 1.5e-108: 360: 25.76
+	Hs
		994696 PCDA8_HUMAN (2-470): 1.82e-86: 298: 16.16		DDR1_HUMAN (535-824): 9.4e-68: 244: 43.63
+	Hs
		968528 PCDA8_HUMAN (2-470): 1.82e-86: 298: 16.16		ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56
+	Hs
		968527 PCDB3_HUMAN (2-475): 2.75e-78: 272: 15.99		ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56
+	Hs
		580228 CADH2_HUMAN (2-385): 2.16e-54: 205: 17.55		DDR1_HUMAN (535-824): 9.4e-68: 244: 43.63
+	Hs
		435531 CADH2_HUMAN (2-385): 2.16e-54: 205: 17.55		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16