Protein: PCGF1
Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68)

Gene: PCGF1
Organism: Homo sapiens
Interactions: 205
UniProt ID: Q9BSM1

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006338 - chromatin remodeling
GO:0006355 - regulation of DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1404731

RING2
E3 ubiquitin-protein ligase RING2

15

20

Small-scale

0.987

High

1250649

BCOR
BCL-6 corepressor

12

20

Small-scale

0.986

High

1055850

RING1
E3 ubiquitin-protein ligase RING1

8

19

Small-scale

0.978

High

1326063

RYBP
RING1 and YY1-binding protein

10

20

Small-scale

0.977

High

1204633

BCORL
BCL-6 corepressor-like protein 1

8

20

Small-scale

0.975

High

1314044

YAF2
YY1-associated factor 2

7

20

Small-scale

0.965

High

1412822

CBX8
Chromobox protein homolog 8

6

20

Small-scale

0.956

High

351402

CBX7
Chromobox protein homolog 7

4

20

High-throughput

0.899

High

129796

CBX4
E3 SUMO-protein ligase CBX4

3

20

Small-scale

0.861

High

338947

CBX6
Chromobox protein homolog 6

3

20

High-throughput

0.853

High

1412803

PCGF1
Polycomb group RING finger protein 1

3

19

Small-scale

0.840

High

419178

H2A1B
Histone H2A type 1-B/E

2

20

Small-scale

0.812

High

1286261

PCGF5
Polycomb group RING finger protein 5

2

19

High-throughput

0.793

High

1340152

KDM2B
Lysine-specific demethylase 2B

12

20

Small-scale

0.760

High

591820

H2AX
Histone H2AX

2

20

Small-scale

0.754

High

998749

H31
Histone H3.1

2

19

High-throughput

0.754

High

992317

SKP1
S-phase kinase-associated protein 1

9

10

Small-scale

0.754

High

765842

BMI1
Polycomb complex protein BMI-1

2

19

High-throughput

0.737

High

1371646

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

5

20

High-throughput

0.718

High

1352165

MORC4
MORC family CW-type zinc finger protein 4

4

3

Small-scale

0.699

High

1389542

RN125
E3 ubiquitin-protein ligase RNF125

1

19

High-throughput

0.698

High

1163177

H2B2E
Histone H2B type 2-E

1

18

High-throughput

0.691

High

155692

FCHO1
F-BAR domain only protein 1

3

2

High-throughput

0.669

High

957180

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

Small-scale

0.647

High

1040753

ENL
Protein ENL

2

13

Small-scale

0.628

High

1218751

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.625

High

502512

H2A1
Histone H2A type 1

1

20

High-throughput

0.618

High

766115

PCGF2
Polycomb group RING finger protein 2

1

19

High-throughput

0.618

High

981055

H2B1C
Histone H2B type 1-C/E/F/G/I

1

18

High-throughput

0.618

High

1017171

H33
Histone H3.3

1

19

High-throughput

0.618

High

1132232

CBX2
Chromobox protein homolog 2

1

20

High-throughput

0.618

High

1185942

PCGF3
Polycomb group RING finger protein 3

1

19

High-throughput

0.618

High

1412809

PCGF6
Polycomb group RING finger protein 6

1

19

High-throughput

0.618

High

839918

AF9
Protein AF-9

2

11

Small-scale

0.611

High

143223

NFIB
Nuclear factor 1 B-type

2

20

High-throughput

0.584

High

474248

NFIC
Nuclear factor 1 C-type

2

20

High-throughput

0.584

High

872691

SOX2
Transcription factor SOX-2

2

20

Small-scale

0.584

High

1133632

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.584

High

1312489

PHC2
Polyhomeotic-like protein 2

2

20

High-throughput

0.584

High

1095775

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

20

High-throughput

0.541

High

1412810

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.541

High

141077

NOP56
Nucleolar protein 56

1

6

Small-scale

0.536

High

174393

ZN609
Zinc finger protein 609

1

9

High-throughput

0.536

High

553055

PIP
Prolactin-inducible protein

1

3

High-throughput

0.536

High

886575

CTCF
Transcriptional repressor CTCF

1

11

Small-scale

0.536

High

888662

YLPM1
YLP motif-containing protein 1

1

16

Small-scale

0.536

High

913026

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

20

Small-scale

0.536

High

1032405

OTUD4
OTU domain-containing protein 4

1

7

Small-scale

0.536

High

1149976

TERF2
Telomeric repeat-binding factor 2

1

4

High-throughput

0.536

High

1203599

ZN326
DBIRD complex subunit ZNF326

1

9

Small-scale

0.536

High

1271216

DPPA4
Developmental pluripotency-associated protein 4

1

2

High-throughput

0.536

High

1290688

ZCH18
Zinc finger CCCH domain-containing protein 18

1

11

Small-scale

0.536

High

1316974

FAM9B
Protein FAM9B

1

2

High-throughput

0.536

High

1412818

NANOG
Homeobox protein NANOG

1

20

High-throughput

0.536

High

1412835

SCML1
Sex comb on midleg-like protein 1

1

20

High-throughput

0.536

High

1412838

ZN148
Zinc finger protein 148

1

11

Small-scale

0.536

High

1412839

KDM2A
Lysine-specific demethylase 2A

1

20

High-throughput

0.536

High

2822

A0A0C3SFZ9
FCH and mu domain containing endocytic adaptor 1

1

2

High-throughput

0.515

High

1347774

MUC7
Mucin-7

1

5

High-throughput

0.512

High

269048

ABCB7
Iron-sulfur clusters transporter ABCB7, mitochondrial

1

3

Small-scale

0.489

High

532911

CH60
60 kDa heat shock protein, mitochondrial

1

7

High-throughput

0.489

High

1178147

QSER1
Glutamine and serine-rich protein 1

1

13

Small-scale

0.489

High

134850

SAP18
Histone deacetylase complex subunit SAP18

1

2

High-throughput

0.479

High

143691

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

7

High-throughput

0.479

High

144315

ACACB
Acetyl-CoA carboxylase 2

1

5

High-throughput

0.479

High

163825

TCRG1
Transcription elongation regulator 1

1

9

High-throughput

0.479

High

181557

TBXT
T-box transcription factor T

1

12

High-throughput

0.479

High

225097

TLX3
T-cell leukemia homeobox protein 3

1

20

High-throughput

0.479

High

282774

E2F6
Transcription factor E2F6

1

15

High-throughput

0.479

High

285443

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

289171

PRDM1
PR domain zinc finger protein 1

1

14

High-throughput

0.479

High

339841

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

373009

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

405622

HRG
Histidine-rich glycoprotein

1

5

High-throughput

0.479

High

461878

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.479

High

468748

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.479

High

520334

ANDR
Androgen receptor

1

19

High-throughput

0.479

High

528336

THIO
Thioredoxin

1

11

High-throughput

0.479

High

538463

EGR2
E3 SUMO-protein ligase EGR2

1

18

High-throughput

0.479

High

540939

ERG
Transcriptional regulator ERG

1

14

High-throughput

0.479

High

590484

GATA1
Erythroid transcription factor

1

16

High-throughput

0.479

High

601840

HMGA1
High mobility group protein HMG-I/HMG-Y

1

2

High-throughput

0.479

High

625590

CSK22
Casein kinase II subunit alpha'

1

20

High-throughput

0.479

High

662271

PAX7
Paired box protein Pax-7

1

16

High-throughput

0.479

High

662491

GATA2
Endothelial transcription factor GATA-2

1

16

High-throughput

0.479

High

662643

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

16

High-throughput

0.479

High

685330

PAX6
Paired box protein Pax-6

1

14

High-throughput

0.479

High

721059

CLIP1
CAP-Gly domain-containing linker protein 1

1

12

High-throughput

0.479

High

725312

TLX1
T-cell leukemia homeobox protein 1

1

20

High-throughput

0.479

High

761852

HSP74
Heat shock 70 kDa protein 4

1

13

Small-scale

0.479

High

775903

HNF1B
Hepatocyte nuclear factor 1-beta

1

15

High-throughput

0.479

High

776119

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.479

High

776239

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

834043

HNF4A
Hepatocyte nuclear factor 4-alpha

1

12

High-throughput

0.479

High

837083

ELK3
ETS domain-containing protein Elk-3

1

13

High-throughput

0.479

High

846932

ETV4
ETS translocation variant 4

1

14

High-throughput

0.479

High

892932

MRE11
Double-strand break repair protein MRE11

1

1

High-throughput

0.479

High

907650

ZN157
Zinc finger protein 157

1

10

High-throughput

0.479

High

938499

PAX9
Paired box protein Pax-9

1

14

High-throughput

0.479

High

940501

DPOE2
DNA polymerase epsilon subunit 2

1

1

High-throughput

0.479

High

942123

SOX10
Transcription factor SOX-10

1

20

High-throughput

0.479

High

944729

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

964729

DCAF7
DDB1- and CUL4-associated factor 7

1

20

High-throughput

0.479

High

980237

H4
Histone H4

1

9

High-throughput

0.479

High

995230

CSK2B
Casein kinase II subunit beta

1

9

High-throughput

0.479

High

997981

CSK21
Casein kinase II subunit alpha

1

20

High-throughput

0.479

High

1006872

PHC1
Polyhomeotic-like protein 1

1

20

High-throughput

0.479

High

1014188

CBX1
Chromobox protein homolog 1

1

20

High-throughput

0.479

High

1029030

TIAR
Nucleolysin TIAR

1

15

High-throughput

0.479

High

1030491

FABP5
Fatty acid-binding protein 5

1

3

High-throughput

0.479

High

1033765

PO5F1
POU domain, class 5, transcription factor 1

1

10

High-throughput

0.479

High

1040073

PAX2
Paired box protein Pax-2

1

14

High-throughput

0.479

High

1052908

HME1
Homeobox protein engrailed-1

1

6

High-throughput

0.479

High

1056642

PAX8
Paired box protein Pax-8

1

14

High-throughput

0.479

High

1087981

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1089000

TP53B
TP53-binding protein 1

1

9

High-throughput

0.479

High

1091245

FOXI1
Forkhead box protein I1

1

11

High-throughput

0.479

High

1091341

FOXL1
Forkhead box protein L1

1

11

High-throughput

0.479

High

1097526

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.479

High

1098370

ERCC8
DNA excision repair protein ERCC-8

1

19

High-throughput

0.479

High

1118768

KLF5
Krueppel-like factor 5

1

20

High-throughput

0.479

High

1128466

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

2

High-throughput

0.479

High

1129722

MDC1
Mediator of DNA damage checkpoint protein 1

1

20

High-throughput

0.479

High

1132030

STAT4
Signal transducer and activator of transcription 4

1

3

High-throughput

0.479

High

1137493

SUZ12
Polycomb protein SUZ12

1

3

High-throughput

0.479

High

1145837

IRF4
Interferon regulatory factor 4

1

9

High-throughput

0.479

High

1157895

DDB1
DNA damage-binding protein 1

1

7

High-throughput

0.479

High

1160888

TBR1
T-box brain protein 1

1

12

High-throughput

0.479

High

1208060

CYTSB
Cytospin-B

1

18

High-throughput

0.479

High

1229371

LHX8
LIM/homeobox protein Lhx8

1

13

High-throughput

0.479

High

1241160

LTMD1
LETM1 domain-containing protein 1

1

1

High-throughput

0.479

High

1244824

FBX38
F-box only protein 38

1

1

High-throughput

0.479

High

1257941

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

1

20

High-throughput

0.479

High

1276719

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

9

High-throughput

0.479

High

1281380

DPPA2
Developmental pluripotency-associated protein 2

1

2

High-throughput

0.479

High

1307192

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

12

High-throughput

0.479

High

1310121

MGAP
MAX gene-associated protein

1

12

High-throughput

0.479

High

1311319

CDAN1
Codanin-1

1

1

High-throughput

0.479

High

1311717

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

8

High-throughput

0.479

High

1327451

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

3

High-throughput

0.479

High

1336930

PHC3
Polyhomeotic-like protein 3

1

20

High-throughput

0.479

High

1338760

ARI1B
AT-rich interactive domain-containing protein 1B

1

13

High-throughput

0.479

High

1347539

SMRC2
SWI/SNF complex subunit SMARCC2

1

18

High-throughput

0.479

High

1351144

SP7
Transcription factor Sp7

1

20

High-throughput

0.479

High

1370087

RENT1
Regulator of nonsense transcripts 1

1

9

High-throughput

0.479

High

1371519

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

20

High-throughput

0.479

High

1379941

LHX4
LIM/homeobox protein Lhx4

1

9

High-throughput

0.479

High

1380955

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

20

High-throughput

0.479

High

1391690

SCMH1
Polycomb protein SCMH1

1

20

High-throughput

0.479

High

1403124

CRBN
Protein cereblon

1

1

High-throughput

0.479

High

1405426

FEV
Protein FEV

1

13

High-throughput

0.479

High

1409545

B9D2
B9 domain-containing protein 2

1

1

High-throughput

0.479

High

1412526

GCP2
Gamma-tubulin complex component 2

1

1

High-throughput

0.479

High

1412804

DIDO1
Death-inducer obliterator 1

1

20

High-throughput

0.479

High

1412805

SSBP3
Single-stranded DNA-binding protein 3

1

4

High-throughput

0.479

High

1412806

KLF16
Krueppel-like factor 16

1

20

High-throughput

0.479

High

1412808

SRRT
Serrate RNA effector molecule homolog

1

1

High-throughput

0.479

High

1412811

SETD2
Histone-lysine N-methyltransferase SETD2

1

7

Small-scale

0.479

High

1412812

NAA50
N-alpha-acetyltransferase 50

1

2

High-throughput

0.479

High

1412813

CHM4B
Charged multivesicular body protein 4b

1

5

High-throughput

0.479

High

1412815

SOX17
Transcription factor SOX-17

1

20

High-throughput

0.479

High

1412816

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1412817

UBP42
Ubiquitin carboxyl-terminal hydrolase 42

1

10

High-throughput

0.479

High

1412819

ELP3
Elongator complex protein 3

1

1

High-throughput

0.479

High

1412821

PATZ1
POZ-, AT hook-, and zinc finger-containing protein 1

1

9

High-throughput

0.479

High

1412828

CDK12
Cyclin-dependent kinase 12

1

12

High-throughput

0.479

High

1412829

IBTK
Inhibitor of Bruton tyrosine kinase

1

10

High-throughput

0.479

High

1412832

XPO7
Exportin-7

1

10

High-throughput

0.479

High

1412833

KLF15
Krueppel-like factor 15

1

20

High-throughput

0.479

High

1412834

GPTC8
G patch domain-containing protein 8

1

16

High-throughput

0.479

High

1412836

ING4
Inhibitor of growth protein 4

1

3

High-throughput

0.479

High

1412840

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.479

High

216799

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.458

High

257272

PQBP1
Polyglutamine-binding protein 1

1

0

High-throughput

0.458

High

915482

HMGA2
High mobility group protein HMGI-C

1

0

High-throughput

0.458

High

1147116

ELOC
Elongin-C

1

0

High-throughput

0.458

High

1331130

PDCD7
Programmed cell death protein 7

1

0

High-throughput

0.458

High

1412823

GCM1
Chorion-specific transcription factor GCMa

1

0

High-throughput

0.458

High

1412831

COE1
Transcription factor COE1

1

0

High-throughput

0.458

High

1412837

SATB2
DNA-binding protein SATB2

1

0

High-throughput

0.458

High

537809

HSP7C
Heat shock cognate 71 kDa protein

1

11

Small-scale

0.445

High

1155713

EZH2
Histone-lysine N-methyltransferase EZH2

1

14

High-throughput

0.445

High

1198647

NCBP3
Nuclear cap-binding protein subunit 3

1

2

High-throughput

0.445

High

271570

ATG13
Autophagy-related protein 13

1

3

High-throughput

0.437

High

616231

PGAM1
Phosphoglycerate mutase 1

1

5

High-throughput

0.437

High

641667

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

2

High-throughput

0.437

High

643553

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

4

High-throughput

0.437

High

857165

NSF
Vesicle-fusing ATPase

1

6

High-throughput

0.437

High

902218

RAB13
Ras-related protein Rab-13

1

6

High-throughput

0.437

High

1248187

SAS6
Spindle assembly abnormal protein 6 homolog

1

15

High-throughput

0.437

High

1315327

ZDH23
Palmitoyltransferase ZDHHC23

1

8

Small-scale

0.437

High

1400897

PRAM
PML-RARA-regulated adapter molecule 1

1

10

High-throughput

0.437

High

1408523

AKAP9
A-kinase anchor protein 9

1

19

High-throughput

0.437

High

1412807

CAR14
Caspase recruitment domain-containing protein 14

1

8

High-throughput

0.437

High

1412814

TOR3A
Torsin-3A

1

1

High-throughput

0.437

High

1412820

FBRS
Probable fibrosin-1

1

20

High-throughput

0.437

High

1412824

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

10

High-throughput

0.437

High

1412825

ZDH18
Palmitoyltransferase ZDHHC18

1

4

Small-scale

0.437

High

1412826

PCMD2
Protein-L-isoaspartate O-methyltransferase domain-containing protein 2

1

4

High-throughput

0.437

High

1412830

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

3

High-throughput

0.437

High

1412827

SETD4
SET domain-containing protein 4

1

0

Small-scale

0.426

High

1272200

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

0

Small-scale

0.279

Low

1054205

P2R3A
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

1

0

High-throughput

0.249

Low

1412229

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025