HitPredict

Interactor 1: IRF3 (Q14653)
Interferon regulatory factor 3 (IRF-3)
Gene: IRF3

Interactor 2: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.91 0.60 0.739

The method score is based on:

Property Details
Experiments 24379373, 33110251, 25636800, 21903422, 22908223, 16153868
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway
GO:0005739 - mitochondrion
GO:0032481 - positive regulation of type I interferon production
GO:0032727 - positive regulation of interferon-alpha production
GO:0032728 - positive regulation of interferon-beta production
and 8 others

more...
Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 427
Hs

1 540
+ Hs
+ Hs
+ Hs
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+ Hs

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Last updated: 15 Jul 2024