Interactor 1: IRF3 (Q14653)
Interferon regulatory factor 3 (IRF-3)
Gene: IRF3
Interactor 2: TBK1 (Q9UHD2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
Gene: TBK1
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.98 | 0.60 | 0.770 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25636800, 25803835, 28346439, 31534043, 33801464, 37130168, 21903422, 22388039, 16394098, 30267576, 19380580, 18636086, 33637958, 19656901, 22072751, 17599067, 22079989, 23028469, 20628368, 12692549 and 13 others
more... |
| Identification Methods | affinity chromatography technology, pull down, enzymatic study, two hybrid, anti tag coimmunoprecipitation, protein kinase assay, in-gel kinase assay, anti bait coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, phosphorylation reaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032481 - positive regulation of type I interferon production and 11 others more... |
| Homologous interactions | 14 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
